Human GDF-11/BMP-11 Antibody | R&D Systems MAB19581 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human GDF-11/BMP-11 Antibody

catalog :

MAB19581

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

743833

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 19

Reference
Sch xf6 n M, Mar x10d ek Malenovsk xe1 K, Nemec M, Alchus Laiferov xe1 N, Straka I, Ko x161 utzk xe1 Z, et al. Acute endurance exercise modulates growth differentiation factor 11 in cerebrospinal fluid of healthy young adults. Front Endocrinol (Lausanne). 2023;14:1137048 pubmed publisher
Zhang Y, Zhang Y, Pan Z, Li Q, Sun L, Li X, et al. GDF11 promotes wound healing in diabetic mice via stimulating HIF-1ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization. Acta Pharmacol Sin. 2023;44:999-1013 pubmed publisher
Sun J, Li Y, Yang X, Dong W, Yang J, Hu Q, et al. Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy. Aging Cell. 2022;21:e13532 pubmed publisher
Li Z, Xu H, Liu X, Hong Y, Lou H, Liu H, et al. GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3. Cell Death Dis. 2020;11:917 pubmed publisher
Qi X, Xiao Q, Sheng R, Jiang S, Yuan Q, Liu W. Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells. J Cell Mol Med. 2020;24:11457-11464 pubmed publisher
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler J, et al. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. JCI Insight. 2020;5: pubmed publisher
Lee M, Oikawa S, Ushida T, Suzuki K, Akimoto T. Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice. Front Physiol. 2019;10:970 pubmed publisher
Cox T, Lidral A, McCoy J, Liu H, Cox L, Zhu Y, et al. Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans. Hum Mutat. 2019;: pubmed publisher
Jin Q, Qiao C, Li J, Xiao B, Li J, Xiao X. A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skelet Muscle. 2019;9:16 pubmed publisher
Ozek C, Krolewski R, Buchanan S, Rubin L. Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. Sci Rep. 2018;8:17293 pubmed publisher
Jin Q, Qiao C, Li J, Li J, Xiao X. Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth. Mol Ther. 2018;26:1109-1117 pubmed publisher
Bajikar S, Wang C, Borten M, Pereira E, Atkins K, Janes K. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Dev Cell. 2017;43:418-435.e13 pubmed publisher
De Domenico E, D Arcangelo G, Faraoni I, Palmieri M, Tancredi V, Graziani G, et al. Modulation of GDF11 expression and synaptic plasticity by age and training. Oncotarget. 2017;8:57991-58002 pubmed publisher
Zimmers T, Jiang Y, Wang M, Liang T, Rupert J, Au E, et al. Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting. Basic Res Cardiol. 2017;112:48 pubmed publisher
Latres E, Mastaitis J, Fury W, Miloscio L, Trejos J, Pangilinan J, et al. Activin A more prominently regulates muscle mass in primates than does GDF8. Nat Commun. 2017;8:15153 pubmed publisher
Li H, Li Y, Xiang L, Zhang J, ZHu B, Xiang L, et al. GDF11 Attenuates Development of Type 2 Diabetes via Improvement of Islet β-Cell Function and Survival. Diabetes. 2017;66:1914-1927 pubmed publisher
Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
Schafer M, Atkinson E, Vanderboom P, Kotajarvi B, White T, Moore M, et al. Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease. Cell Metab. 2016;23:1207-1215 pubmed publisher
Rodgers B. The Immateriality of Circulating GDF11. Circ Res. 2016;118:1472-4 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB19581

SKU :

MAB19581

product name :

Human GDF-11/BMP-11 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human GDF-11/BMP-11 Antibody from R&D Systems is a mouse monoclonal antibody to GDF-11/BMP-11. This antibody reacts with human,mouse,primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque),rat. The Human GDF-11/BMP-11 Antibody has been validated for the following applications: ELISA Development,Western Blot,Neutralization,Immunohistochemistry,In vivo assay.

target :

GDF-11/BMP-11

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

743833

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Immunohistochemistry 8-25 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human GDF-11/BMP-11, Asn299-Ser407, Accession # O95390

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque),Rat

specificity :

Detects human GDF-11/BMP-11 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human BMP-6 or recombinant mouse GDF-8 is observed.

gene symbol :

GDF11

top caption :

GDF-11/BMP-11 antibody in Human Colon Cancer Tissue by Immunohistochemistry (IHC-P).

accessionNumbers :

O95390

applications :

ELISA Development,Immunohistochemistry,Western Blot,In vivo assay,Neutralization

USD :

479 USD

alt names :

BMP11, BMP-11, BMP-11BMP11Bone morphogenetic protein 11, GDF11, GDF-11, growth differentiation factor 11, growth/differentiation factor 11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage