This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Human CCR6 Antibody
catalog :
MAB195
quantity :
100 ug (also 25 ug, 500 ug)
price :
359 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
53103
reactivity :
human
application :
immunohistochemistry, flow cytometry
citations: 32
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 4
Sullivan A, Wang E, Farrell J, Whitaker P, Faulkner L, Peckham D, et al. ?-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells. J Allergy Clin Immunol. 2018;141:235-249.e8 pubmed publisher
Klimczak A, Suchnicki K, Sedzimirska M, Lange A. Diverse Activity of IL-17+ Cells in Chronic Skin and Mucosa Graft-Versus-Host Disease. Arch Immunol Ther Exp (Warsz). 2019;: pubmed publisher
Balzano T, Forteza J, Molina P, Giner J, Monzó A, Sancho Jiménez J, et al. The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons. Sci Rep. 2018;8:3004 pubmed publisher
Zhang X, Hu Z, Meng A, Duan G, Zhao Q, Yang J. Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma. Oncol Lett. 2017;14:8183-8189 pubmed publisher
Soto B, Gallastegi Mozos T, Rodriguez C, Martinez Gonzalez J, Escudero J, Vila L, et al. Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm. Sci Rep. 2017;7:17331 pubmed publisher
Diao R, Wang T, Fok K, Li X, Ruan Y, Yu M, et al. CCR6 is required for ligand-induced CatSper activation in human sperm. Oncotarget. 2017;8:91445-91458 pubmed publisher
Dunham J, van Driel N, Eggen B, Paul C, t Hart B, Laman J, et al. Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset. Clin Transl Immunology. 2017;6:e127 pubmed publisher
Szczeklik W, Jakieła B, Wawrzycka Adamczyk K, Sanak M, Hubalewska Mazgaj M, Padjas A, et al. Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis. Eur J Immunol. 2017;47:724-733 pubmed publisher
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
Kapur N, Mir H, Clark Iii C, Krishnamurti U, Beech D, Lillard J, et al. CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. Br J Cancer. 2016;114:1343-51 pubmed publisher
Schanz A, Red Horse K, Hess A, Baston Büst D, Heiss C, Krüssel J. Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression. Placenta. 2014;35:1089-94 pubmed publisher
Huijskens M, Walczak M, Koller N, Briedé J, Senden Gijsbers B, Schnijderberg M, et al. Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells. J Leukoc Biol. 2014;96:1165-75 pubmed publisher
Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, et al. CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE. 2014;9:e101137 pubmed publisher
Nandi B, Pai C, Huang Q, Prabhala R, Munshi N, Gold J. CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS ONE. 2014;9:e97566 pubmed publisher
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, et al. Increased Th17/Treg ratio in chronic liver GVHD. Bone Marrow Transplant. 2014;49:539-44 pubmed publisher
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, et al. Increased plasmacytoid dendritic cells and ROR?t-expressing immune effectors in cutaneous acute graft-versus-host disease. J Leukoc Biol. 2013;94:1337-43 pubmed publisher
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A. Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol. 2013;131:1146-56, 1156.e1-5 pubmed publisher
Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, et al. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin Cancer Res. 2011;17:7529-38 pubmed publisher
Pandya A, Al Jaderi Z, Høglund R, Holmøy T, Harbo H, Norgauer J, et al. Identification of human NK17/NK1 cells. PLoS ONE. 2011;6:e26780 pubmed publisher
Kim S, Lewis C, Nadel J. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011;186:3392-400 pubmed publisher
Charles J, Di Domizio J, Salameire D, Bendriss Vermare N, Aspord C, Muhammad R, et al. Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J Invest Dermatol. 2010;130:1646-56 pubmed publisher
Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
Bergeron A, El Hage F, Kambouchner M, Lecossier D, Tazi A. Characterisation of dendritic cell subsets in lung cancer micro-environments. Eur Respir J. 2006;28:1170-7 pubmed
Marchal Sommé J, Uzunhan Y, Marchand Adam S, Valeyre D, Soumelis V, Crestani B, et al. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol. 2006;176:5735-9 pubmed
Lim H, Hillsamer P, Kim C. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest. 2004;114:1640-9 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Page G, Miossec P. Paired synovium and lymph nodes from rheumatoid arthritis patients differ in dendritic cell and chemokine expression. J Pathol. 2004;204:28-38 pubmed
Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P. Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression. Am J Pathol. 2004;164:409-17 pubmed
Annels N, Willemze A, van der Velden V, Faaij C, van Wering E, Sie Go D, et al. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004;103:2806-8 pubmed
Maki W, Morales R, Carroll V, Telford W, Knibbs R, Stoolman L, et al. CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. J Immunol. 2002;169:2346-53 pubmed
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol. 2001;166:6477-82 pubmed
product information
brand :
R&D Systems
master code :
MAB195
SKU :
MAB195-100
product name :
Human CCR6 Antibody
description :
The Human CCR6 Antibody from R&D Systems is a mouse monoclonal antibody to CCR6. This antibody reacts with human. The Human CCR6 Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, CyTOF-ready.
target :
CCR6
category :
Primary Antibodies
unit size :
100 ug (also 25 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
53103
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
NS0 mouse myeloma cell line transfected with human CCR6, Met1-Met374, Accession # P51684
isotype :
IgG2b
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.
gene symbol :
CCR6
catalog number base :
MAB195
accessionNumbers :
P51684
applications :
Flow Cytometry, Immunohistochemistry, CyTOF-ready
extended description :
Clone 53103 was used by HLDA to establish CD designation
2020 USD :
339
2021 USD :
359 USD
product details :
Clone 53103 was used by HLDA to establish CD designation
alt names :
BN-1, CC-CKR-6, CCR6, CCR-6, CD196, CD196 antigen, chemokine (C-C motif) receptor 6, CKRL3, CKR-L3, CKR-L3G-protein coupled receptor 29, CKRL3LARC receptor, CMKBR6, CMKBR6STRL22, DRY6, GPR29, GPR29C-C CKR-6, GPRCY4, GPR-CY4, GPRCY4DRY-6, lymphocyte, 22, STRL22
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.