Human CCR6 Antibody | R&D Systems MAB195-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR6 Antibody

catalog :

MAB195-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

53103

reactivity :

human, mouse, rat, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 37

Reference
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Balzano T, Leone P, Ivaylova G, Castro M, Reyes L, Ramón C, et al. Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage. Biomedicines. 2021;9: pubmed publisher
Bharucha J, Sun L, Lu W, Gartner S, Garzino Demo A. Human Beta-Defensin 2 and 3 Inhibit HIV-1 Replication in Macrophages. Front Cell Infect Microbiol. 2021;11:535352 pubmed publisher
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, et al. Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2020;117:7305-7316 pubmed publisher
Balzano T, Forteza J, Molina P, Giner J, MonzÃ³ A, Sancho JimÃ©nez J, et al. The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons. Sci Rep. 2018;8:3004 pubmed publisher
Zhang X, Hu Z, Meng A, Duan G, Zhao Q, Yang J. Role of CCL20/CCR6 and the ERK signaling pathway in lung adenocarcinoma. Oncol Lett. 2017;14:8183-8189 pubmed publisher
Soto B, Gallastegi Mozos T, Rodriguez C, Martinez Gonzalez J, Escudero J, Vila L, et al. Circulating CCL20 as a New Biomarker of Abdominal Aortic Aneurysm. Sci Rep. 2017;7:17331 pubmed publisher
Diao R, Wang T, Fok K, Li X, Ruan Y, Yu M, et al. CCR6 is required for ligand-induced CatSper activation in human sperm. Oncotarget. 2017;8:91445-91458 pubmed publisher
Dunham J, van Driel N, Eggen B, Paul C, t Hart B, Laman J, et al. Analysis of the cross-talk of Epstein-Barr virus-infected B cells with T cells in the marmoset. Clin Transl Immunology. 2017;6:e127 pubmed publisher
Szczeklik W, Jakieła B, Wawrzycka Adamczyk K, Sanak M, Hubalewska Mazgaj M, Padjas A, et al. Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis. Eur J Immunol. 2017;47:724-733 pubmed publisher
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
Shang L, Duan L, Perkey K, Wietgrefe S, Zupancic M, Smith A, et al. Epithelium-innate immune cell axis in mucosal responses to SIV. Mucosal Immunol. 2017;10:508-519 pubmed publisher
Kapur N, Mir H, Clark Iii C, Krishnamurti U, Beech D, Lillard J, et al. CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. Br J Cancer. 2016;114:1343-51 pubmed publisher
Schanz A, Red Horse K, Hess A, Baston BÃ¼st D, Heiss C, KrÃ¼ssel J. Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression. Placenta. 2014;35:1089-94 pubmed publisher
Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, et al. CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE. 2014;9:e101137 pubmed publisher
Nandi B, Pai C, Huang Q, Prabhala R, Munshi N, Gold J. CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS ONE. 2014;9:e97566 pubmed publisher
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, et al. Increased Th17/Treg ratio in chronic liver GVHD. Bone Marrow Transplant. 2014;49:539-44 pubmed publisher
Malard F, Bossard C, Brissot E, Chevallier P, Guillaume T, Delaunay J, et al. Increased plasmacytoid dendritic cells and ROR?t-expressing immune effectors in cutaneous acute graft-versus-host disease. J Leukoc Biol. 2013;94:1337-43 pubmed publisher
Chen B, Zhang D, Zhou J, Li Q, Zhou L, Li S, et al. High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma. Oncol Rep. 2013;30:1380-90 pubmed publisher
Caballero Campo P, Buffone M, Benencia F, Conejo Garcia J, Rinaudo P, Gerton G. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. J Cell Physiol. 2014;229:68-78 pubmed publisher
Mazerolles F, Picard C, Kracker S, Fischer A, Durandy A. Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol. 2013;131:1146-56, 1156.e1-5 pubmed publisher
Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, et al. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin Cancer Res. 2011;17:7529-38 pubmed publisher
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Kim S, Lewis C, Nadel J. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011;186:3392-400 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB195

SKU :

MAB195-100

product name :

Human CCR6 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human CCR6 Antibody from R&D Systems is a mouse monoclonal antibody to CCR6. This antibody reacts with human,mouse,primate,primate - macaca mulatta (rhesus macaque),rat. The Human CCR6 Antibody has been validated for the following applications: Bioassay,Blocking,Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.

target :

CCR6

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

53103

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CCR6, Met1-Met374, Accession # P51684

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human,Mouse,Primate,Primate - Macaca mulatta (Rhesus Macaque),Rat

specificity :

Detects human CCR6. Stains human CCR6 transfectants but not the parental cell line in flow cytometry. Does not cross-react with transfectants expressing human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CXCR1, CXCR2, CXCR3, CXCR4, or STRL33.

gene symbol :

CCR6

top caption :

CCR6 antibody in Human Spleen by Immunohistochemistry (IHC-P).

accessionNumbers :

P51684

applications :

CyTOF-ready,Bioassay,Blocking,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

extended description :

Clone 53103 was used by HLDA to establish CD designation

USD :

479 USD

product details :

Clone 53103 was used by HLDA to establish CD designation

alt names :

BN-1, CC-CKR-6, CCR6, CCR-6, CD196, CD196 antigen, chemokine (C-C motif) receptor 6, CKRL3, CKR-L3, CKR-L3G-protein coupled receptor 29, CKRL3LARC receptor, CMKBR6, CMKBR6STRL22, DRY6, GPR29, GPR29C-C CKR-6, GPRCY4, GPR-CY4, GPRCY4DRY-6, lymphocyte, 22, STRL22

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage