This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Human NKp46/NCR1 Antibody
catalog :
MAB1850
quantity :
100 ug (also 25 ug, 500 ug)
price :
369 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
195314
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100; loading ...; fig 1, 5
Sellier Y, Marliot F, Bessières B, Stirnemann J, Encha Razavi F, Guilleminot T, et al. Adaptive and Innate Immune Cells in Fetal Human Cytomegalovirus-Infected Brains. Microorganisms. 2020;8: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s2a
Hervier B, Perez M, Allenbach Y, Devilliers H, Cohen F, Uzunhan Y, et al. Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome. J Immunol. 2016;197:1621-30 pubmed publisher
Trotta A, Santagata S, Zanotta S, D Alterio C, Napolitano M, Rea G, et al. Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity. J Exp Clin Cancer Res. 2018;37:297 pubmed publisher
Maron S, Alpert L, Kwak H, Lomnicki S, Chase L, Xu D, et al. Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for EGFR-Amplified Gastroesophageal Adenocarcinoma. Cancer Discov. 2018;8:696-713 pubmed publisher
Feng Y, Liao S, Wei C, Jia D, Wood K, Liu Q, et al. Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models. J Neuroinflammation. 2017;14:248 pubmed publisher
Shi J, Zhao J, Zhang X, Cheng Y, Hu J, Li Y, et al. Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients. Sci Rep. 2017;7:44544 pubmed publisher
Messaoudene M, Fregni G, Enot D, Jacquelot N, Neves E, Germaud N, et al. NKp30 isoforms and NKp46 transcripts in metastatic melanoma patients: Unique NKp30 pattern in rare melanoma patients with favorable evolution. Oncoimmunology. 2016;5:e1154251 pubmed publisher
Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, et al. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45:131-44 pubmed publisher
Hudspeth K, Donadon M, Cimino M, Pontarini E, Tentorio P, Preti M, et al. Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways. J Autoimmun. 2016;66:40-50 pubmed publisher
Messaoudene M, Périer A, Fregni G, Neves E, Zitvogel L, Cremer I, et al. Characterization of the Microenvironment in Positive and Negative Sentinel Lymph Nodes from Melanoma Patients. PLoS ONE. 2015;10:e0133363 pubmed publisher
Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, et al. A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells. MAbs. 2014;6:728-39 pubmed publisher
Carrega P, Bonaccorsi I, Di Carlo E, Morandi B, Paul P, Rizzello V, et al. CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph. J Immunol. 2014;192:3805-15 pubmed publisher
Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, et al. Natural killer cells are characterized by the concomitantly increased interferon-? and cytotoxicity in acute resolved hepatitis B patients. PLoS ONE. 2012;7:e49135 pubmed publisher
Keim S, Zoernig I, Spille A, Lahrmann B, Brand K, Herpel E, et al. Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments. Oncoimmunology. 2012;1:593-599 pubmed
Durrenberger P, Ettorre A, Kamel F, Webb L, Sim M, Nicholas R, et al. Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1). J Neuroinflammation. 2012;9:1 pubmed publisher
Yu J, Mitsui T, Wei M, Mao H, Butchar J, Shah M, et al. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. J Clin Invest. 2011;121:1456-70 pubmed publisher
Dulphy N, Haas P, Busson M, Belhadj S, Peffault De Latour R, Robin M, et al. An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J Immunol. 2008;181:2227-37 pubmed
Shi J, Tricot G, Garg T, Malaviarachchi P, Szmania S, Kellum R, et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood. 2008;111:1309-17 pubmed
Meresse B, Curran S, Ciszewski C, Orbelyan G, Setty M, Bhagat G, et al. Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med. 2006;203:1343-55 pubmed
Warren H, Bettadapura J. A novel binding assay to assess specificity of monoclonal antibodies. J Immunol Methods. 2005;305:33-8 pubmed
product information
brand :
R&D Systems
master code :
MAB1850
SKU :
MAB1850-100
product name :
Human NKp46/NCR1 Antibody
description :
The Human NKp46/NCR1 Antibody from R&D Systems is a mouse monoclonal antibody to NKp46/NCR1. This antibody reacts with human. The Human NKp46/NCR1 Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Agonist Activity, Immunocytochemistry, CyTOF-reported.
target :
NKp46/NCR1
category :
Primary Antibodies
unit size :
100 ug (also 25 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
195314
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse T cell hybridoma transfected with human NKp46/NCR1
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human NKp46/NCR1 in direct ELISAs and Western blots.
gene symbol :
NCR1
details of functionality :
ActivityAssaywCitation not found None None None None None
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
catalog number base :
MAB1850
applications :
Western Blot, Flow Cytometry, Immunohistochemistry, Agonist Activity, Immunocytochemistry, CyTOF-reported
extended description :
Clone 195314 was used by HLDA to establish CD designation
2020 USD :
339
2021 USD :
369 USD
product details :
Clone 195314 was used by HLDA to establish CD designation
alt names :
CD335, CD335 antigen, hNKp46, Ly94, LY94lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46), Lymphocyte antigen 94 homolog, MAR-1, natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCR1, NK cell-activating receptor, NKp46, NKP46FLJ99094, NK-p46lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.