This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
TGF-beta 1, 2, 3 Antibody
catalog :
MAB1835
quantity :
100 ug (also 25 ug, 500 ug)
price :
369 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1D11
reactivity :
human, mouse
application :
western blot, ELISA, neutralization, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments
citations: 142
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; loading ...
Bon H, Hales P, Lumb S, Holdsworth G, Johnson T, Qureshi O, et al. Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins. Nephron. 2019;:1-23 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4a
Yin J, Wang Y, Chang J, Li B, Zhang J, Liu Y, et al. Apelin inhibited epithelial-mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i. Cell Death Dis. 2018;9:1031 pubmed publisher
  • flow cytometry; mouse; fig 4d
Cummings R, Barbet G, Bongers G, Hartmann B, Gettler K, Muniz L, et al. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs. Nature. 2016;539:565-569 pubmed publisher
  • blocking or activating experiments; human; 5 ug/ml; loading ...
Cirillo N, Hassona Y, Celentano A, Lim K, Manchella S, Parkinson E, et al. Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer. Carcinogenesis. 2017;38:76-85 pubmed publisher
  • blocking or activating experiments; mouse; 10 ug/ml; loading ...; fig 2b
Yoon J, Leyva Castillo J, Wang G, Galand C, Oyoshi M, Kumar L, et al. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016;213:2147-66 pubmed publisher
  • blocking or activating experiments; human; fig 2a
Yang W, Deng Y, Hsieh Y, Wu K, Kuo M. Thrombin Activates Latent TGF?1 via Integrin ?v?1 in Gingival Fibroblasts. J Dent Res. 2016;95:939-45 pubmed publisher
  • blocking or activating experiments; human; loading ...; fig 4c
Nguyen H, Kadam P, Helkin A, Cao K, Wu S, Samara G, et al. MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer. Curr Cancer Drug Targets. 2016;16:618-30 pubmed
van Caam A, Aarts J, van Ee T, Vitters E, Koenders M, van de Loo F, et al. TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?. Arthritis Res Ther. 2020;22:42 pubmed publisher
Takagaki Y, Lee S, Dongqing Z, Kitada M, Kanasaki K, Koya D. Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis. Autophagy. 2020;:1-10 pubmed publisher
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher
Shokri M, Bozorgmehr M, Ghanavatinejad A, Falak R, Aleahmad M, Kazemnejad S, et al. Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells. Sci Rep. 2019;9:10007 pubmed publisher
Wang W, Ishibashi J, Trefely S, Shao M, Cowan A, Sakers A, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 2019;: pubmed publisher
Yu H, Ma S, Sun L, Gao J, Zhao C. TGF‑β1 upregulates the expression of lncRNA‑ATB to promote atherosclerosis. Mol Med Rep. 2019;19:4222-4228 pubmed publisher
Wang B, Wu S, Ma Z, Wang T, Yang C. BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model. Cell Death Dis. 2018;9:1024 pubmed publisher
Shindo T, Doi S, Nakashima A, Sasaki K, Arihiro K, Masaki T. TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA. Sci Rep. 2018;8:14060 pubmed publisher
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed publisher
Liu B, Xu L, Yu X, Li W, Sun X, Xiao S, et al. Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α. Mol Med Rep. 2018;18:1987-1994 pubmed publisher
Wang X, Dong F, Zhang S, Yang W, Yu W, Wang Z, et al. TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells. Stem Cell Reports. 2018;11:274-287 pubmed publisher
Tiwary S, Morales J, Kwiatkowski S, Lang F, Rao G, McCarty J. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. Sci Rep. 2018;8:8267 pubmed publisher
Huang L, Deng J, Xu W, Wang H, Shi L, Wu F, et al. CD8+ T cells with high TGF‑β1 expression cause lymph node fibrosis following HIV infection. Mol Med Rep. 2018;18:77-86 pubmed publisher
Wong C, Falkenham A, Myers T, Legare J. Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis. J Renin Angiotensin Aldosterone Syst. 2018;19:1470320318759358 pubmed publisher
Said S, Barut G, Mansur N, Korkmaz A, Sayı Yazgan A. Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression. Mol Immunol. 2018;96:48-60 pubmed publisher
Cortes J, Ambesi Impiombato A, Couronné L, Quinn S, Kim C, da Silva Almeida A, et al. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018;33:259-273.e7 pubmed publisher
Yuan M, Pai P, Liu X, Lam H, Chan B. Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts. Sci Rep. 2018;8:1512 pubmed publisher
Caronni N, Simoncello F, Stafetta F, Guarnaccia C, Ruiz Moreno J, Opitz B, et al. Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer. Cancer Res. 2018;78:1685-1699 pubmed publisher
Qureshi O, Bon H, Twomey B, Holdsworth G, Ford K, Bergin M, et al. An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix. Biol Open. 2017;6:1423-1433 pubmed publisher
Pasztoi M, Pezoldt J, Beckstette M, Lipps C, Wirth D, Rohde M, et al. Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells. Eur J Immunol. 2017;47:2142-2152 pubmed publisher
Petri R, Hackel A, Hahnel K, Dumitru C, Bruderek K, Flohé S, et al. Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function. Stem Cell Reports. 2017;9:985-998 pubmed publisher
Khakipoor S, Ophoven C, Schrödl Häußel M, Feuerstein M, Heimrich B, Deitmer J, et al. TGF-β signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes. Glia. 2017;65:1361-1375 pubmed publisher
Bohlen C, Bennett F, Tucker A, Collins H, Mulinyawe S, Barres B. Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures. Neuron. 2017;94:759-773.e8 pubmed publisher
Gonzalez D, Contreras O, Rebolledo D, Espinoza J, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS ONE. 2017;12:e0177649 pubmed publisher
Köstlin N, Vogelmann M, Spring B, Schwarz J, Feucht J, Hartel C, et al. Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype. Immunology. 2017;152:89-101 pubmed publisher
Ritsma L, Dey Guha I, Talele N, Sole X, Salony -, Chowdhury J, et al. Integrin ?1 activation induces an anti-melanoma host response. PLoS ONE. 2017;12:e0175300 pubmed publisher
Bian Q, Ma L, Jain A, Crane J, Kebaish K, Wan M, et al. Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res. 2017;5:17008 pubmed publisher
Brekke K, Sommerfelt M, Okvist M, Dyrhol Riise A, Kvale D. The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study. BMC Infect Dis. 2017;17:228 pubmed publisher
Urban D, Anthwal N, Luo Z, Maier J, Sadier A, Tucker A, et al. A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw. Proc Biol Sci. 2017;284: pubmed publisher
Gatla H, Zou Y, Uddin M, Singha B, Bu P, Vancura A, et al. Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells. J Biol Chem. 2017;292:5043-5054 pubmed publisher
Mellone M, Hanley C, Thirdborough S, Mellows T, Garcia E, Woo J, et al. Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis. Aging (Albany NY). 2016;9:114-132 pubmed publisher
Smith I, Baker A, Christensen J, Boekhout T, Frøkiær H, Arneborg N, et al. Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro. PLoS ONE. 2016;11:e0167410 pubmed publisher
Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 2017;127:321-334 pubmed publisher
Cortini M, Massa A, Avnet S, Bonuccelli G, Baldini N. Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion. PLoS ONE. 2016;11:e0166500 pubmed publisher
Kurbet A, Hegde S, Bhattacharjee O, Marepally S, Vemula P, Raghavan S. Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin. Cell Rep. 2016;16:3334-3347 pubmed publisher
Scherer S, Bauer J, Schmaus A, Neumaier C, Herskind C, Veldwijk M, et al. TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT). PLoS ONE. 2016;11:e0162221 pubmed publisher
Josowitz R, Mulero Navarro S, Rodriguez N, Falce C, Cohen N, Ullian E, et al. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016;7:355-369 pubmed publisher
Bonnefoy F, Daoui A, Valmary Degano S, Toussirot E, Saas P, Perruche S. Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy. Arthritis Res Ther. 2016;18:184 pubmed publisher
Roussa E, Speer J, Chudotvorova I, Khakipoor S, Smirnov S, Rivera C, et al. The membrane trafficking and functionality of the K+-Cl- co-transporter KCC2 is regulated by TGF-?2. J Cell Sci. 2016;129:3485-98 pubmed publisher
Minn I, Koo S, Lee H, Brummet M, Rowe S, Gorin M, et al. [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma. Oncotarget. 2016;7:56471-56479 pubmed publisher
Mirzamohammadi F, Papaioannou G, Inloes J, Rankin E, Xie H, Schipani E, et al. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nat Commun. 2016;7:12047 pubmed publisher
Chen X, Rateri D, Howatt D, Balakrishnan A, Moorleghen J, Cassis L, et al. TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions. PLoS ONE. 2016;11:e0153811 pubmed publisher
Nagashima H, Okuyama Y, Hayashi T, Ishii N, So T. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. J Immunol. 2016;196:4082-9 pubmed publisher
Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, et al. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-?. Immunol Cell Biol. 2016;94:747-62 pubmed publisher
Carthy J, Engström U, Heldin C, Moustakas A. Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling. J Cell Biochem. 2016;117:938-45 pubmed publisher
Kippenberger S, Zöller N, Kleemann J, Müller J, Kaufmann R, Hofmann M, et al. STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk. PLoS ONE. 2015;10:e0131783 pubmed publisher
Fornetti J, Flanders K, Henson P, Tan A, Borges V, Schedin P. Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization. Cell Death Differ. 2016;23:185-96 pubmed publisher
Dayer C, Stamenkovic I. Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation. J Biol Chem. 2015;290:13763-78 pubmed publisher
Pieters B, Arntz O, Bennink M, Broeren M, van Caam A, Koenders M, et al. Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β. PLoS ONE. 2015;10:e0121123 pubmed publisher
Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, et al. Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium. J Biol Chem. 2015;290:11918-34 pubmed publisher
Dutta A, Huang C, Chen T, Lin C, Chiu C, Lin Y, et al. IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection. Nat Commun. 2015;6:6374 pubmed publisher
Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El Sayed K, et al. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β. PLoS ONE. 2015;10:e0118097 pubmed publisher
Chang T, Poltoratsky V, Vancurova I. Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells. J Immunol. 2015;194:2942-53 pubmed publisher
Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong J, et al. Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region. J Immunol. 2015;194:113-24 pubmed publisher
Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. Lab Invest. 2015;95:193-206 pubmed publisher
Schmetterer K, Neunkirchner A, Wojta Stremayr D, Leitner J, Steinberger P, Pickl W. STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells. FASEB J. 2015;29:759-71 pubmed publisher
Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, et al. Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation. J Biol Chem. 2014;289:35246-63 pubmed publisher
Carrillo Galvez A, Cobo M, Cuevas Ocaña S, Gutiérrez Guerrero A, Sánchez Gilabert A, Bongarzone P, et al. Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells. 2015;33:183-95 pubmed publisher
Hassona Y, Cirillo N, Heesom K, Parkinson E, Prime S. Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer. 2014;111:1230-7 pubmed publisher
Guzman E, Hope J, Taylor G, Smith A, Cubillos Zapata C, Charleston B. Bovine ?? T cells are a major regulatory T cell subset. J Immunol. 2014;193:208-22 pubmed publisher
Alcaraz L, Exposito J, Chuvin N, Pommier R, Cluzel C, Martel S, et al. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-?. J Cell Biol. 2014;205:409-28 pubmed publisher
Gao P, Zhou Y, Xian L, Li C, Xu T, Plunkett B, et al. Functional effects of TGF-?1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma. J Immunol. 2014;192:4560-4570 pubmed publisher
Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, et al. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1? transgenic mice. Immunology. 2014;141:401-15 pubmed publisher
Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, et al. The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol. 2014;15:449-56 pubmed publisher
Faustino L, Fonseca D, Florsheim E, Resende R, Lepique A, Faquim Mauro E, et al. Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation. Mucosal Immunol. 2014;7:1199-208 pubmed publisher
Cook J, Carta L, Benard L, Chemaly E, Chiu E, Rao S, et al. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. J Clin Invest. 2014;124:1329-39 pubmed publisher
Weaver S, Wolters B, Ito N, Woskowicz A, Kaneko K, Shitomi Y, et al. Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix. J Cell Sci. 2014;127:1203-13 pubmed publisher
Craft C, Pietka T, Schappe T, Coleman T, Combs M, Klein S, et al. The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-?. Diabetes. 2014;63:1920-32 pubmed publisher
Chakrabarti L, Wang B, Lee N, Sandler A. A mechanism linking Id2-TGF? crosstalk to reversible adaptive plasticity in neuroblastoma. PLoS ONE. 2013;8:e83521 pubmed publisher
Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B. Biglycan and decorin differentially regulate signaling in the fetal membranes. Matrix Biol. 2014;35:266-75 pubmed publisher
Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D. The metalloprotease ADAM12 regulates the effector function of human Th17 cells. PLoS ONE. 2013;8:e81146 pubmed publisher
Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, et al. Angiotensin II-dependent TGF-? signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014;124:448-60 pubmed publisher
Musso A, Catellani S, Canevali P, Tavella S, Vené R, Boero S, et al. Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor V? 2 T lymphocytes in non-Hodgkin lymphomas. Haematologica. 2014;99:131-9 pubmed publisher
Bialas A, Stevens B. TGF-? signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat Neurosci. 2013;16:1773-82 pubmed publisher
Gandhi N, Su Z, Zhang X, Volpe E, Pelegrino F, Rahman S, et al. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013;94:1293-301 pubmed publisher
Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, et al. PARP-1 regulates expression of TGF-? receptors in T cells. Blood. 2013;122:2224-32 pubmed publisher
Yu C, Becker C, Wang Y, Marches F, Helft J, Leboeuf M, et al. Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-?. Immunity. 2013;38:818-30 pubmed publisher
Nakagawa R, Togawa A, Nagasawa T, Nishikawa S. Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture. J Immunol. 2013;190:3309-18 pubmed publisher
Schreiner J, Kretschmer D, Klenk J, Otto M, Bühring H, Stevanovic S, et al. Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells. J Immunol. 2013;190:3417-26 pubmed publisher
Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity. 2013;38:309-21 pubmed publisher
Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, et al. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J Immunol. 2013;190:3153-62 pubmed publisher
Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, et al. CD2-mediated regulation of peripheral CD4(+)  CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim. Immunology. 2013;139:48-60 pubmed publisher
Zhang N, Bevan M. TGF-? signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol. 2012;13:667-73 pubmed publisher
Zielinski C, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, et al. Pathogen-induced human TH17 cells produce IFN-? or IL-10 and are regulated by IL-1?. Nature. 2012;484:514-8 pubmed publisher
Ma W, Han W, Greer P, Tuder R, Toque H, Wang K, et al. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest. 2011;121:4548-66 pubmed publisher
Montane J, Bischoff L, Soukhatcheva G, Dai D, Hardenberg G, Levings M, et al. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest. 2011;121:3024-8 pubmed publisher
Gregory P, Bracken C, Smith E, Bert A, Wright J, Roslan S, et al. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell. 2011;22:1686-98 pubmed publisher
Srivastava K, Zhang T, Yang N, Sampson H, Li X. Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-?, but not transforming growth factor-? dependent. Clin Exp Allergy. 2010;40:1678-88 pubmed publisher
Lu H, Wagner W, Gad E, Yang Y, Duan H, Amon L, et al. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade. J Immunol. 2010;184:5360-7 pubmed publisher
Tso G, Law H, Tu W, Chan G, Lau Y. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells. 2010;28:939-54 pubmed publisher
Koo J, Russo S, Ferguson D, Nestler E, Duman R. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A. 2010;107:2669-74 pubmed publisher
Linke A, Goren I, Bösl M, Pfeilschifter J, Frank S. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1. J Invest Dermatol. 2010;130:866-75 pubmed publisher
Prignano F, Campolmi P, Bonan P, Ricceri F, Cannarozzo G, Troiano M, et al. Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair. Dermatol Ther. 2009;22 Suppl 1:S8-15 pubmed publisher
Han G, Wang R, Chen G, Wang J, Xu R, Wang L, et al. Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Immunology. 2010;129:197-206 pubmed publisher
Ilarregui J, Croci D, Bianco G, Toscano M, Salatino M, Vermeulen M, et al. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol. 2009;10:981-91 pubmed publisher
Schraml B, Hildner K, Ise W, Lee W, Smith W, Solomon B, et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009;460:405-9 pubmed publisher
Aliahmadi E, Gramlich R, Grützkau A, Hitzler M, Krüger M, Baumgrass R, et al. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol. 2009;39:1221-30 pubmed publisher
Nicola T, Hagood J, James M, MacEwen M, Williams T, Hewitt M, et al. Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am J Physiol Lung Cell Mol Physiol. 2009;296:L738-50 pubmed publisher
Tran D, Glass D, Uzel G, Darnell D, Spalding C, Holland S, et al. Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J Immunol. 2009;182:2929-38 pubmed publisher
Han Y, Guo Q, Zhang M, Chen Z, Cao X. CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J Immunol. 2009;182:111-20 pubmed
Pen A, Moreno M, Durocher Y, Deb Rinker P, Stanimirovic D. Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene. 2008;27:6834-44 pubmed publisher
Akool E, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, et al. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. J Immunol. 2008;181:2831-45 pubmed
Carlson M, Hsu M, Conboy I. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature. 2008;454:528-32 pubmed publisher
van der Vliet H, Wang R, Yue S, Koon H, Balk S, Exley M. Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. J Immunol. 2008;180:7287-93 pubmed
Perruche S, Zhang P, Liu Y, Saas P, Bluestone J, Chen W. CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat Med. 2008;14:528-35 pubmed publisher
Haanstra K, van der Maas M, t Hart B, Jonker M. Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys. Transplantation. 2008;85:1185-92 pubmed publisher
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product information
brand :
R&D Systems
master code :
MAB1835
SKU :
MAB1835-100
product name :
TGF-beta 1, 2, 3 Antibody
description :
The TGF-beta 1, 2, 3 Antibody from R&D Systems is a mouse monoclonal antibody to TGF beta 1/2/3. This antibody reacts with multi-species. The TGF-beta 1, 2, 3 Antibody has been validated for the following applications: Western Blot, Binding Inhibition, Neutralization, ELISA Capture (Matched Antibody Pair).
target :
TGF beta 1/2/3
category :
Primary Antibodies
unit size :
100 ug (also 25 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
1D11
conjugate :
Unconjugated
host :
Mouse
immunogen :
Bovine bone-derived TGF-beta 1 and TGF-beta 2
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Multi-Species
specificity :
Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3. No cross-reactivity was observed with recombinant LAP in direct ELISAs.
gene symbol :
TGFB1
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
catalog number base :
MAB1835
applications :
Western Blot, Binding Inhibition, Neutralization, ELISA Capture (Matched Antibody Pair)
2020 USD :
339
2021 USD :
369 USD
alt names :
ARVD1, CED, DPD1, LAP, LDS5, RNHF, TGF beta1, TGFB, TGFB1, TGFB2, TGFB3, TGFbeta, TGFbeta 1, TGFbeta 2, TGFbeta 3, transforming growth factor, beta 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.