product summary
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company name :
R&D Systems
product type :
antibody
product name :
TGF┐▀1, 2, 3 Antibody
catalog :
MAB1835-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1D11
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, activation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot, blocking or activating experiments
more info or order :
citations: 226
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; 5 ug/ml; loading ...; fig 5f
Wang X, Liu S, Yu T, An S, Deng R, Tan X, et al. Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy. Adv Sci (Weinh). 2022;9:e2104469 pubmed publisher
  • flow cytometry; human; loading ...; fig 2
Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
Jeong H, Koh J, Kim S, Song S, Lee S, Jeon Y, et al. Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer. Br J Cancer. 2024;131:23-36 pubmed publisher
Seller A, Tegeler C, Mauermann J, Schreiber T, Hagelstein I, Liebel K, et al. Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome. Int J Mol Sci. 2024;25: pubmed publisher
Kostadinova R, Str xf6 bel S, Chen L, Fiaschetti Egli K, Gadient J, Pawlowska A, et al. Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model. Sci Rep. 2024;14:5885 pubmed publisher
Petillo S, Sproviero E, Loconte L, Cuollo L, Zingoni A, Molfetta R, et al. NEDD8-activating enzyme inhibition potentiates the anti-myeloma activity of natural killer cells. Cell Death Dis. 2023;14:438 pubmed publisher
Michielon E, L xf3 pez Gonz xe1 lez M, Stolk D, Stolwijk J, Roffel S, Waaijman T, et al. A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion. Cancers (Basel). 2023;15: pubmed publisher
Marvin D, Dijkstra J, Zulfiqar R, Vermeulen M, Ten Dijke P, Ritsma L. TGF-β Type I Receptor Signaling in Melanoma Liver Metastases Increases Metastatic Outgrowth. Int J Mol Sci. 2023;24: pubmed publisher
Carneiro C, Hapeman J, Nedelcu A. Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones. BMC Ecol Evol. 2023;23:20 pubmed publisher
Vondra S, H xf6 bler A, Lackner A, Raffetseder J, Mihalic Z, Vogel A, et al. The human placenta shapes the phenotype of decidual macrophages. Cell Rep. 2023;42:111977 pubmed publisher
Fionda C, Ruggeri S, Scium xe8 G, Laffranchi M, Quinti I, Milito C, et al. Age-dependent NK cell dysfunctions in severe COVID-19 patients. Front Immunol. 2022;13:1039120 pubmed publisher
Gringhuis S, Kaptein T, Remmerswaal E, Drewniak A, Wevers B, Theelen B, et al. Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs. Nat Immunol. 2022;23:1735-1748 pubmed publisher
Zeng W, Xiong L, Wu W, Li S, Liu J, Yang L, et al. CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype. Oncogene. 2022;: pubmed publisher
Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam M, Ahmed S, et al. Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration. Nat Commun. 2022;13:7058 pubmed publisher
Maldonado L, Nascimento C, Rodrigues Fernandes N, Silva A, D Silva N, Rossa C. Influence of tumor cell-derived TGF-β on macrophage phenotype and macrophage-mediated tumor cell invasion. Int J Biochem Cell Biol. 2022;153:106330 pubmed publisher
Takahashi M, Hashimoto Y, Nakamura Y. Anti-TGF-β1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model. Mol Ther Nucleic Acids. 2022;29:969-978 pubmed publisher
Shen Z, Luo W, Tan B, Nie K, Deng M, Wu S, et al. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease. EBioMedicine. 2022;85:104285 pubmed publisher
Otsuki T, Fukuda N, Chen L, Tsunemi A, Abe M. Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3. PLoS ONE. 2022;17:e0272917 pubmed publisher
Hanna J, Beke F, O Brien L, Kapeni C, Chen H, Carbonaro V, et al. Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity. Nat Commun. 2022;13:4075 pubmed publisher
Yin G, Kim D, Kang J, Im Y, Lee D, Han A, et al. Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function. Exp Mol Med. 2022;54:626-638 pubmed publisher
Liu J, Zhang J, Lin X, Boyce B, Zhang H, Xing L. Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice. J Clin Invest. 2022;132: pubmed publisher
Pinkaew D, Martinez Hackert E, Jia W, King M, Miao F, Enger N, et al. Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation. Commun Biol. 2022;5:157 pubmed publisher
Lutz M, Klimovich B, Maurer S, Heitmann J, M xe4 rklin M, Zekri L, et al. Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies. J Immunother Cancer. 2022;10: pubmed publisher
Bruno M, Mukherjee S, Stromberg A, Saito H, Starr M. Visceral fat-specific regulation of plasminogen activator inhibitor-1 in aged septic mice. J Cell Physiol. 2022;237:706-719 pubmed publisher
He J, Du Y, Li G, Xiao P, Sun X, Song W, et al. Myeloid Fbxw7 Prevents Pulmonary Fibrosis by Suppressing TGF-β Production. Front Immunol. 2021;12:760138 pubmed publisher
Pieters B, Arntz O, Aarts J, Feitsma A, van Neerven R, van der Kraan P, et al. Bovine Milk-Derived Extracellular Vesicles Inhibit Catabolic and Inflammatory Processes in Cartilage from Osteoarthritis Patients. Mol Nutr Food Res. 2021;:e2100764 pubmed publisher
Basak D, Jamal Z, Ghosh A, Mondal P, Dey Talukdar P, Ghosh S, et al. Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis. PLoS ONE. 2021;16:e0255915 pubmed publisher
Mestrallet G, Auvré F, Schenowitz C, Carosella E, Lemaoult J, Martin M, et al. Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints. Cells. 2021;10: pubmed publisher
Duffy L, Henderson J, Brown M, Pryzborski S, Fullard N, Summa L, et al. Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis. Front Cell Dev Biol. 2021;9:681061 pubmed publisher
Playford R, Weiser M, Marchbank T. Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar. PLoS ONE. 2021;16:e0253422 pubmed publisher
Manian K, Galloway C, Dalvi S, Emanuel A, Mereness J, Black W, et al. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration. Cell Stem Cell. 2021;28:846-862.e8 pubmed publisher
Patel M, Weaver A. Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling. Cell Rep. 2021;34:108829 pubmed publisher
Liang Q, Xie J, Yu C, Feng Z, Ma J, Zhang Y, et al. Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-β1 signaling pathway. Exp Mol Med. 2021;53:393-406 pubmed publisher
Liang Z, Ge X, Xu M, Qin H, Wu M, Shen M, et al. Tumor-associated macrophages promote the metastasis and growth of non-small-cell lung cancer cells through NF-κB/PP2Ac-positive feedback loop. Cancer Sci. 2021;112:2140-2157 pubmed publisher
Ungefroren H, Otterbein H, Wellner U, Keck T, Lehnert H, Marquardt J. RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility. Cancers (Basel). 2020;12: pubmed publisher
Iyer S, Zhang S, Yucel S, Horn H, Smith S, Reinhardt F, et al. Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Cancer Discov. 2021;11:384-407 pubmed publisher
Evanko S, Gooden M, Kang I, Chan C, Vernon R, Wight T. A Role for HAPLN1 During Phenotypic Modulation of Human Lung Fibroblasts In Vitro. J Histochem Cytochem. 2020;68:797-811 pubmed publisher
Luzina I, Fishelevich R, Hampton B, Courneya J, Parisella F, Lugkey K, et al. Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner. Cell Immunol. 2020;357:104203 pubmed publisher
Elashiry M, Elashiry M, Elsayed R, Rajendran M, Auersvald C, Zeitoun R, et al. Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo. J Extracell Vesicles. 2020;9:1795362 pubmed publisher
Gomes A, Ilter D, Low V, Endress J, Fernández García J, Rosenzweig A, et al. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020;585:283-287 pubmed publisher
Campesato L, Budhu S, Tchaicha J, Weng C, Gigoux M, Cohen I, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020;11:4011 pubmed publisher
Sapski S, Beha N, Kontermann R, M xfc ller D. Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response. Cancer Immunol Immunother. 2020;69:2291-2303 pubmed publisher
Kaji D, Howell K, Balic Z, Hubmacher D, HUANG A. TGFβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration. elife. 2020;9: pubmed publisher
Li W, Elshikha A, Cornaby C, Teng X, Abboud G, BROWN J, et al. T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice. JCI Insight. 2020;5: pubmed publisher
Rodríguez Sánchez E, Navarro García J, Aceves Ripoll J, Abarca Zabalía J, Susmozas Sánchez A, Bada Bosch T, et al. Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy. Biomolecules. 2020;10: pubmed publisher
Qin F, Liu X, Chen J, Huang S, Wei W, Zou Y, et al. Anti-TGF-β attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer. J Cancer. 2020;11:2580-2592 pubmed publisher
van Caam A, Aarts J, van Ee T, Vitters E, Koenders M, van de Loo F, et al. TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?. Arthritis Res Ther. 2020;22:42 pubmed publisher
Zhang K, Yang C, Chang L, Sakamoto A, Suzuki T, Fujita Y, et al. Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1. Transl Psychiatry. 2020;10:32 pubmed publisher
Richardson L, Taylor R, Menon R. Reversible EMT and MET mediate amnion remodeling during pregnancy and labor. Sci Signal. 2020;13: pubmed publisher
Li S, Fan Y, Kumagai A, Kawakita E, Kitada M, Kanasaki K, et al. Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGFβ Signaling Pathway in Breast Cancer Cells. Int J Mol Sci. 2020;21: pubmed publisher
Takagaki Y, Lee S, Dongqing Z, Kitada M, Kanasaki K, Koya D. Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis. Autophagy. 2020;:1-10 pubmed publisher
Hancock M, Crawford L, Pham A, Mitchell J, Struthers H, Yurochko A, et al. Human Cytomegalovirus miRNAs Regulate TGF-β to Mediate Myelosuppression while Maintaining Viral Latency in CD34+ Hematopoietic Progenitor Cells. Cell Host Microbe. 2020;27:104-114.e4 pubmed publisher
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher
Budi E, Hoffman S, Gao S, Zhang Y, Derynck R. Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells. Sci Rep. 2019;9:16992 pubmed publisher
Emrich F, Penov K, Arakawa M, Dhablania N, Burdon G, Pedroza A, et al. Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation. J Cell Mol Med. 2019;23:7000-7009 pubmed publisher
Shokri M, Bozorgmehr M, Ghanavatinejad A, Falak R, Aleahmad M, Kazemnejad S, et al. Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells. Sci Rep. 2019;9:10007 pubmed publisher
Wang W, Ishibashi J, Trefely S, Shao M, Cowan A, Sakers A, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 2019;: pubmed publisher
Ligorio M, Sil S, Malagon Lopez J, Nieman L, Misale S, Di Pilato M, et al. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019;: pubmed publisher
Yu H, Ma S, Sun L, Gao J, Zhao C. TGF‑β1 upregulates the expression of lncRNA‑ATB to promote atherosclerosis. Mol Med Rep. 2019;19:4222-4228 pubmed publisher
Wang G, Zhang J, Fang Y, Cao W, Xu B, Chen X. Stimulation of tolerogenic dendritic cells using dexamethasone and 1,25-dihydroxyvitamin D3 represses autologous T cell activation and chondrocyte inflammation. Exp Ther Med. 2019;17:679-688 pubmed publisher
Wang B, Wu S, Ma Z, Wang T, Yang C. BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model. Cell Death Dis. 2018;9:1024 pubmed publisher
Shindo T, Doi S, Nakashima A, Sasaki K, Arihiro K, Masaki T. TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA. Sci Rep. 2018;8:14060 pubmed publisher
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed publisher
Liu B, Xu L, Yu X, Li W, Sun X, Xiao S, et al. Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α. Mol Med Rep. 2018;18:1987-1994 pubmed publisher
Wang X, Dong F, Zhang S, Yang W, Yu W, Wang Z, et al. TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells. Stem Cell Reports. 2018;11:274-287 pubmed publisher
Tiwary S, Morales J, Kwiatkowski S, Lang F, Rao G, McCarty J. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. Sci Rep. 2018;8:8267 pubmed publisher
Huang L, Deng J, Xu W, Wang H, Shi L, Wu F, et al. CD8+ T cells with high TGF‑β1 expression cause lymph node fibrosis following HIV infection. Mol Med Rep. 2018;18:77-86 pubmed publisher
Wong C, Falkenham A, Myers T, Legare J. Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis. J Renin Angiotensin Aldosterone Syst. 2018;19:1470320318759358 pubmed publisher
Said S, Barut G, Mansur N, Korkmaz A, Sayı Yazgan A. Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression. Mol Immunol. 2018;96:48-60 pubmed publisher
Cortes J, Ambesi Impiombato A, Couronné L, Quinn S, Kim C, da Silva Almeida A, et al. RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis. Cancer Cell. 2018;33:259-273.e7 pubmed publisher
Yuan M, Pai P, Liu X, Lam H, Chan B. Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts. Sci Rep. 2018;8:1512 pubmed publisher
Caronni N, Simoncello F, Stafetta F, Guarnaccia C, Ruiz Moreno J, Opitz B, et al. Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer. Cancer Res. 2018;78:1685-1699 pubmed publisher
Linares Clemente P, Aguilar Morante D, Rodríguez Prieto I, Ramirez G, de Torres C, Santamaría V, et al. Neural crest derived progenitor cells contribute to tumor stroma and aggressiveness in stage 4/M neuroblastoma. Oncotarget. 2017;8:89775-89792 pubmed publisher
Metzler V, Pritz C, Riml A, Romani A, Tuertscher R, Steinbichler T, et al. Separation of cell survival, growth, migration, and mesenchymal transdifferentiation effects of fibroblast secretome on tumor cells of head and neck squamous cell carcinoma. Tumour Biol. 2017;39:1010428317705507 pubmed publisher
Espinoza Sánchez N, Vadillo E, Balandrán J, Monroy García A, Pelayo R, Fuentes Panana E. Evidence of lateral transmission of aggressive features between different types of breast cancer cells. Int J Oncol. 2017;51:1482-1496 pubmed publisher
Holdsworth G, Bon H, Bergin M, Qureshi O, Paveley R, Atkinson J, et al. Quantitative and organisational changes in mature extracellular matrix revealed through high-content imaging of total protein fluorescently stained in situ. Sci Rep. 2017;7:9963 pubmed publisher
Pasztoi M, Pezoldt J, Beckstette M, Lipps C, Wirth D, Rohde M, et al. Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells. Eur J Immunol. 2017;47:2142-2152 pubmed publisher
Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, et al. CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017;8:286 pubmed publisher
Petri R, Hackel A, Hahnel K, Dumitru C, Bruderek K, Flohé S, et al. Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function. Stem Cell Reports. 2017;9:985-998 pubmed publisher
Li J, Shi S, Srivastava S, Kitada M, Nagai T, Nitta K, et al. FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway. Cell Death Dis. 2017;8:e2965 pubmed publisher
Rachidi S, Metelli A, Riesenberg B, Wu B, Nelson M, Wallace C, et al. Platelets subvert T cell immunity against cancer via GARP-TGF? axis. Sci Immunol. 2017;2: pubmed publisher
Tipton A, Musall J, Crislip G, Sullivan J. Greater transforming growth factor-β in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regulatory cells. Am J Physiol Renal Physiol. 2017;313:F847-F853 pubmed publisher
Khakipoor S, Ophoven C, Schrödl Häußel M, Feuerstein M, Heimrich B, Deitmer J, et al. TGF-β signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes. Glia. 2017;65:1361-1375 pubmed publisher
Bohlen C, Bennett F, Tucker A, Collins H, Mulinyawe S, Barres B. Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures. Neuron. 2017;94:759-773.e8 pubmed publisher
Gonzalez D, Contreras O, Rebolledo D, Espinoza J, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS ONE. 2017;12:e0177649 pubmed publisher
Köstlin N, Vogelmann M, Spring B, Schwarz J, Feucht J, Hartel C, et al. Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype. Immunology. 2017;152:89-101 pubmed publisher
Ritsma L, Dey Guha I, Talele N, Sole X, Salony -, Chowdhury J, et al. Integrin ?1 activation induces an anti-melanoma host response. PLoS ONE. 2017;12:e0175300 pubmed publisher
Bian Q, Ma L, Jain A, Crane J, Kebaish K, Wan M, et al. Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res. 2017;5:17008 pubmed publisher
Brekke K, Sommerfelt M, Okvist M, Dyrhol Riise A, Kvale D. The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study. BMC Infect Dis. 2017;17:228 pubmed publisher
Urban D, Anthwal N, Luo Z, Maier J, Sadier A, Tucker A, et al. A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw. Proc Biol Sci. 2017;284: pubmed publisher
Gatla H, Zou Y, Uddin M, Singha B, Bu P, Vancura A, et al. Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells. J Biol Chem. 2017;292:5043-5054 pubmed publisher
Mellone M, Hanley C, Thirdborough S, Mellows T, Garcia E, Woo J, et al. Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis. Aging (Albany NY). 2016;9:114-132 pubmed publisher
Smith I, Baker A, Christensen J, Boekhout T, Frøkiær H, Arneborg N, et al. Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro. PLoS ONE. 2016;11:e0167410 pubmed publisher
Coster A, Thorne C, Wu L, Altschuler S. Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways. J Biol Chem. 2017;292:244-250 pubmed publisher
Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 2017;127:321-334 pubmed publisher
Cortini M, Massa A, Avnet S, Bonuccelli G, Baldini N. Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion. PLoS ONE. 2016;11:e0166500 pubmed publisher
Cummings R, Barbet G, Bongers G, Hartmann B, Gettler K, Muniz L, et al. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs. Nature. 2016;539:565-569 pubmed publisher
Cirillo N, Hassona Y, Celentano A, Lim K, Manchella S, Parkinson E, et al. Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer. Carcinogenesis. 2017;38:76-85 pubmed publisher
Kurbet A, Hegde S, Bhattacharjee O, Marepally S, Vemula P, Raghavan S. Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin. Cell Rep. 2016;16:3334-3347 pubmed publisher
Scherer S, Bauer J, Schmaus A, Neumaier C, Herskind C, Veldwijk M, et al. TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT). PLoS ONE. 2016;11:e0162221 pubmed publisher
Josowitz R, Mulero Navarro S, Rodriguez N, Falce C, Cohen N, Ullian E, et al. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2016;7:355-369 pubmed publisher
Bonnefoy F, Daoui A, Valmary Degano S, Toussirot E, Saas P, Perruche S. Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy. Arthritis Res Ther. 2016;18:184 pubmed publisher
Duan F, Jia D, Zhao J, Wu W, Min L, Song S, et al. Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer. Oncotarget. 2016;7:38427-39 pubmed publisher
Roussa E, Speer J, Chudotvorova I, Khakipoor S, Smirnov S, Rivera C, et al. The membrane trafficking and functionality of the K+-Cl- co-transporter KCC2 is regulated by TGF-?2. J Cell Sci. 2016;129:3485-98 pubmed publisher
Minn I, Koo S, Lee H, Brummet M, Rowe S, Gorin M, et al. [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma. Oncotarget. 2016;7:56471-56479 pubmed publisher
Mirzamohammadi F, Papaioannou G, Inloes J, Rankin E, Xie H, Schipani E, et al. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nat Commun. 2016;7:12047 pubmed publisher
Chen X, Rateri D, Howatt D, Balakrishnan A, Moorleghen J, Cassis L, et al. TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions. PLoS ONE. 2016;11:e0153811 pubmed publisher
Nagashima H, Okuyama Y, Hayashi T, Ishii N, So T. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. J Immunol. 2016;196:4082-9 pubmed publisher
Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, et al. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-?. Immunol Cell Biol. 2016;94:747-62 pubmed publisher
Mewhort H, Lipon B, Svystonyuk D, Teng G, Guzzardi D, Silva C, et al. Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1. Am J Physiol Heart Circ Physiol. 2016;310:H716-24 pubmed publisher
Liu T, Ren J, Wang W, Wei X, Shen G, Liu Y, et al. Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells. Sci Rep. 2015;5:16760 pubmed publisher
Bedinger D, Lao L, Khan S, Lee S, Takeuchi T, Mirza A. Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms. MAbs. 2016;8:389-404 pubmed publisher
Li H, Li D, Sun J, Li Y, Yang W, Li Y. Autoimmune regulator‑overexpressing dendritic cells induce T helper 1 and T helper 17 cells by upregulating cytokine expression. Mol Med Rep. 2016;13:565-71 pubmed publisher
Yuan H, Reddy M, Deshpande S, Jia Y, Park J, Lanting L, et al. Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy. Antioxid Redox Signal. 2016;24:361-75 pubmed publisher
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product information
brand :
R&D Systems
master code :
MAB1835
SKU :
MAB1835-100
product name :
TGF┐▀1, 2, 3 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The TGF¿ß1, 2, 3 Antibody from R&D Systems is a mouse monoclonal antibody to TGF beta 1/2/3. This antibody reacts with avian - chicken,bovine,canine,hamster,human,mink,mouse,multi-species,opossum,porcine,primate - macaca mulatta (rhesus macaque),rabbit,rat,transgenic mouse. The TGF¿ß1, 2, 3 Antibody has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,ELISA Capture,Neutralization,Flow Cytometry,Bioassay,Activation,Blocking,Co-IP,ELISA Development,ELISA Development (Capture),Immunodepletion,Luminex Development,Western Blot,Dot Blot,Agonist Activity,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,Binding Inhibition,ELISA Capture (Matched Antibody Pair).
target :
TGF-beta 1, 2, 3
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
1D11
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Binding Inhibition, Neutralization 0.25-1.25 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
Bovine bone-derived TGF┐▀1 and TGF┐▀2
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Avian - Chicken,Bovine,Canine,Hamster,Human,Mink,Mouse,Multi-Species,Opossum,Porcine,Primate - Macaca mulatta (Rhesus Macaque),Rabbit,Rat,Transgenic Mouse
specificity :
Detects bovine, chicken, mouse, and human TGF┐▀ in ELISAs and Western blots. It recognizes human TGF┐▀1, TGF┐▀2, and TGF┐▀3. No cross-reactivity was observed with recombinant LAP in direct ELISAs.
gene symbol :
TGFB1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
TGF-ss1 Inhibition of IL-4-dependent Cell Proliferation and Neutralization by TGF-ss1, 2, 3 Antibody.
applications :
Binding Inhibition,ELISA Capture (Matched Antibody Pair),Activation,Bioassay,Blocking,Co-IP,ELISA Development,ELISA Development (Capture),Immunodepletion,Luminex Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Dot Blot,In vivo assay,Agonist Activity,Neutralization,Immunocytochemistry,Functional Assay,ELISA Capture
USD :
469 USD
alt names :
ARVD1, CED, DPD1, LAP, LDS5, RNHF, TGF beta1, TGFB, TGFB1, TGFB2, TGFB3, TGFbeta, TGFbeta 1, TGFbeta 2, TGFbeta 3, transforming growth factor, beta 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.