Human CCR5 Antibody | R&D Systems MAB182 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR5 Antibody

catalog :

MAB182

quantity :

100 ug (also 25 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

45531

reactivity :

human

application :

immunocytochemistry, neutralization, flow cytometry, blocking or activating experiments

citations: 25

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 10 ug/ml; loading ...; fig 4j flow cytometry; human; loading ...; fig 2f, 2g	Dangaj D, Bruand M, Grimm A, Ronet C, Barras D, Duttagupta P, et al. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. 2019;35:885-900.e10 pubmed publisher
flow cytometry; human; loading ...; fig 1b	Nishikawa G, Kawada K, Nakagawa J, Toda K, Ogawa R, Inamoto S, et al. Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5. Cell Death Dis. 2019;10:264 pubmed publisher
flow cytometry; human; 1:50; fig s5d	Wu W, Grotefend C, Tsai M, Wang Y, Radic V, Eoh H, et al. ?20 IFITM2 differentially restricts X4 and R5 HIV-1. Proc Natl Acad Sci U S A. 2017;114:7112-7117 pubmed publisher
	Colin P, Zhou Z, Staropoli I, Garcia Perez J, Gasser R, Armani Tourret M, et al. CCR5 structural plasticity shapes HIV-1 phenotypic properties. PLoS Pathog. 2018;14:e1007432 pubmed publisher
	Lee J, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, et al. The HIV co-receptor CCR5 regulates osteoclast function. Nat Commun. 2017;8:2226 pubmed publisher
	Ward S, Li K, Hepburn E, Weston C, Curbishley S, Reynolds G, et al. The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer. Br J Cancer. 2015;112:319-28 pubmed publisher
	Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, et al. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res. 2014;20:3422-33 pubmed publisher
	Nakano Y, Monde K, Terasawa H, Yuan Y, Yusa K, Harada S, et al. Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1. Virology. 2014;452-453:117-24 pubmed publisher
	Flegler A, Cianci G, Hope T. CCR5 conformations are dynamic and modulated by localization, trafficking and G protein association. PLoS ONE. 2014;9:e89056 pubmed publisher
	Alonzo F, Kozhaya L, Rawlings S, Reyes Robles T, Dumont A, Myszka D, et al. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature. 2013;493:51-5 pubmed publisher
	Duluc D, Gannevat J, Anguiano E, Zurawski S, Carley M, Boreham M, et al. Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol. 2013;6:626-38 pubmed publisher
	Jung D, Che Z, Kim J, Kim K, Kim K, Williams D, et al. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int J Cancer. 2010;127:332-44 pubmed publisher
	Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
	Hartl D, Krauss Etschmann S, Koller B, Hordijk P, Kuijpers T, Hoffmann F, et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol. 2008;181:8053-67 pubmed
	Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, et al. Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions. Int J Cancer. 2008;122:769-76 pubmed
	Bolovan Fritts C, Spector S. Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction. Blood. 2008;111:175-82 pubmed
	Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
	Abonyo B, Lebby K, Tonry J, Ahmad M, Heiman A. Modulation of eotaxin-3 (CCL26) in alveolar type II epithelial cells. Cytokine. 2006;36:237-44 pubmed
	Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
	Lepej S, Rode O, Jeren T, Vince A, Remenar A, Barsic B. Increased expression of CXCR3 and CCR5 on memory CD4+ T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis: the role of CXCL10 and CXCL11. J Neuroimmunol. 2005;163:128-34 pubmed
	Lim H, Hillsamer P, Kim C. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest. 2004;114:1640-9 pubmed
	Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, et al. CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell Signal. 2005;17:355-63 pubmed
	Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle M, et al. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J Leukoc Biol. 2003;73:584-90 pubmed
	Howard O, Dong H, Yang D, Raben N, Nagaraju K, Rosen A, et al. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med. 2002;196:781-91 pubmed
	Lee B, Sharron M, Blanpain C, Doranz B, Vakili J, Setoh P, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274:9617-26 pubmed

product information

brand :

R&D Systems

master code :

MAB182

SKU :

MAB182-100

product name :

Human CCR5 Antibody

description :

The Human CCR5 Antibody from R&D Systems is a mouse monoclonal antibody to CCR5. This antibody reacts with human. The Human CCR5 Antibody has been validated for the following applications: Flow Cytometry, Neutralization, Immunocytochemistry, CyTOF-ready.

target :

CCR5

category :

Primary Antibodies

unit size :

100 ug (also 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

45531

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CCR5, Met1-Leu352, Accession # P51681

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human CCR5.

gene symbol :

CCR5

details of functionality :

ActivityAssaywCitation not found None None None

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB182

accessionNumbers :

P51681

applications :

Flow Cytometry, Neutralization, Immunocytochemistry, CyTOF-ready

2020 USD :

339

2021 USD :

369 USD

alt names :

C-C CKR-5, C-C motif chemokine receptor 5 A159A, CCCKR5, CC-CKR-5FLJ78003, CCR5, CCR-5, CD195, CD195 antigen, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemr13, CKR5, CKR-5, HIV-1 fusion coreceptor, IDDM22CMKBR5C-C chemokine receptor type 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.