Mouse TIM-1/KIM-1/HAVCR Antibody | R&D Systems MAB1817-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse TIM-1/KIM-1/HAVCR Antibody

catalog :

MAB1817-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

222414

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 24

Reference
McLarnon S, Honeycutt S, N Guetta P, Xiong Y, Li X, Abe K, et al. Altered renal vascular patterning reduces ischemic kidney injury and limits vascular loss associated with aging. bioRxiv. 2024;: pubmed publisher
Rietjens R, Wang G, van der Velden A, Koudijs A, Avramut M, Kooijman S, et al. Phosphatidylinositol metabolism of the renal proximal tubule S3 segment is disturbed in response to diabetes. Sci Rep. 2023;13:6261 pubmed publisher
Wang G, Heijs B, Kostidis S, Mahfouz A, Rietjens R, Bijkerk R, et al. Analyzing cell-type-specific dynamics of metabolism in kidney repair. Nat Metab. 2022;4:1109-1118 pubmed publisher
Matsuura K, Maehara N, Hirota A, Eguchi A, Yasuda K, Taniguchi K, et al. Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1. Commun Biol. 2022;5:783 pubmed publisher
Lau A, Rahn J, Chappellaz M, Chung H, Benediktsson H, Bihan D, et al. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Sci Adv. 2022;8:eabm0142 pubmed publisher
Pongking T, Haonon O, Dangtakot R, Onsurathum S, Jusakul A, Intuyod K, et al. A combination of monosodium glutamate and high-fat and high-fructose diets increases the risk of kidney injury, gut dysbiosis and host-microbial co-metabolism. PLoS ONE. 2020;15:e0231237 pubmed publisher
Nozaki Y, Ri J, Sakai K, Niki K, Funauchi M, Matsumura I. Protective Effects of Recombinant Human Soluble Thrombomodulin on Lipopolysaccharide-Induced Acute Kidney Injury. Int J Mol Sci. 2020;21: pubmed publisher
Manning J, Shah S, Henshall T, Nikolic A, Finnie J, Kumar S. Dietary sodium modulates nephropathy in Nedd4-2-deficient mice. Cell Death Differ. 2020;27:1832-1843 pubmed publisher
Chiba T, Peasley K, Cargill K, Maringer K, Bharathi S, Mukherjee E, et al. Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. J Am Soc Nephrol. 2019;30:2384-2398 pubmed publisher
Zhang M, Sasaki K, Li Y, Li Z, Pan Y, Jin G, et al. The Role of the EGF Receptor in Sex Differences in Kidney Injury. J Am Soc Nephrol. 2019;30:1659-1673 pubmed publisher
Chen J, You H, Li Y, Xu Y, He Q, Harris R. EGF Receptor-Dependent YAP Activation Is Important for Renal Recovery from AKI. J Am Soc Nephrol. 2018;29:2372-2385 pubmed publisher
Lau A, Chung H, Komada T, Platnich J, Sandall C, Choudhury S, et al. Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury. J Clin Invest. 2018;128:2894-2913 pubmed publisher
Henshall T, Manning J, Alfassy O, Goel P, Boase N, Kawabe H, et al. Deletion of Nedd4-2 results in progressive kidney disease in mice. Cell Death Differ. 2017;24:2150-2160 pubmed publisher
Zhang M, Wang X, Wang Y, Niu A, Wang S, Zou C, et al. IL-4/IL-13-mediated polarization of renal macrophages/dendritic cells to an M2a phenotype is essential for recovery from acute kidney injury. Kidney Int. 2017;91:375-386 pubmed publisher
Wang Y, Chang J, Yao B, Niu A, Kelly E, Breeggemann M, et al. Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury. Kidney Int. 2015;88:1274-1282 pubmed publisher
Yang L, Brooks C, Xiao S, Sabbisetti V, Yeung M, Hsiao L, et al. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest. 2015;125:1620-36 pubmed publisher
Yano T, Nozaki Y, Kinoshita K, Hino S, Hirooka Y, Niki K, et al. The pathological role of IL-18RÎ± in renal ischemia/reperfusion injury. Lab Invest. 2015;95:78-91 pubmed publisher
Sabbisetti V, Waikar S, Antoine D, Smiles A, Wang C, Ravisankar A, et al. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol. 2014;25:2177-86 pubmed publisher
Cuadros T, Trilla E, Sarró E, Vila M, Vilardell J, de Torres I, et al. HAVCR/KIM-1 activates the IL-6/STAT-3 pathway in clear cell renal cell carcinoma and determines tumor progression and patient outcome. Cancer Res. 2014;74:1416-28 pubmed publisher
Zhang M, Yao B, Yang S, Jiang L, Wang S, Fan X, et al. CSF-1 signaling mediates recovery from acute kidney injury. J Clin Invest. 2012;122:4519-32 pubmed publisher
Nozaki Y, Nikolic Paterson D, Snelgrove S, Akiba H, Yagita H, Holdsworth S, et al. Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis. Kidney Int. 2012;81:844-55 pubmed publisher
Zhang M, Yao B, Wang S, Fan X, Wu G, Yang H, et al. Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J Clin Invest. 2011;121:2845-54 pubmed publisher
Kim H, Kim H, Lee C, Chung D. T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production. J Immunol. 2010;184:4095-106 pubmed publisher
Nakae S, Iikura M, Suto H, Akiba H, Umetsu D, DeKruyff R, et al. TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood. 2007;110:2565-8 pubmed

product information

master code :

MAB1817

SKU :

MAB1817-100

product name :

Mouse TIM-1/KIM-1/HAVCR Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse TIM-1/KIM-1/HAVCR Antibody from R&D Systems is a rat monoclonal antibody to TIM-1/KIM-1/HAVCR. This antibody reacts with hamster,human,mouse,transgenic mouse. The Mouse TIM-1/KIM-1/HAVCR Antibody has been validated for the following applications: ELISA Capture,Immunohistochemistry,ELISA Development,ELISA Development (Capture),Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).

target :

TIM-1/KIM-1/HAVCR

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

222414

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TIM-1/KIM-1/HAVCR, Tyr22-Thr212, Accession # NP_001160104

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Hamster,Human,Mouse,Transgenic Mouse

specificity :

Detects mouse TIM-1/KIM-1/HAVCR in ELISAs and Western blots. This antibody does not cross-react with recombinant human (rh) TIM-1, rmTIM-2, or rmTIM-3.

gene symbol :

HAVCR1

accessionNumbers :

NP_001160104

applications :

ELISA Capture,Immunohistochemistry,ELISA Development,ELISA Development (Capture),Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,ELISA Capture (Matched Antibody Pair)

USD :

489 USD

alt names :

CD365, HAVCR1, HAVCR-1, HAVCRT cell immunoglobin domain and mucin domain protein 1, hepatitis A virus cellular receptor 1, Kidney injury molecule 1, KIM1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIM1, TIM-1TIM, TIM1TIMD-1, TIMD1T-cell membrane protein 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage