Human CCR5 Antibody | R&D Systems MAB181-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR5 Antibody

catalog :

MAB181-100

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

45523

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 17

Reference
Zhu R, Sang X, Zhou J, Meng Q, Huang L, Xu Y, et al. CXCR4 Recognition by L- and D-Peptides Containing the Full-Length V3 Loop of HIV-1 gp120. Viruses. 2023;15: pubmed publisher
Weichseldorfer M, Tagaya Y, Reitz M, DeVico A, Latinovic O. Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies. J Transl Med. 2022;20:39 pubmed publisher
Song S, Manook M, Kwun J, Jackson A, Knechtle S, Kelsoe G. A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines. Commun Biol. 2021;4:1338 pubmed publisher
Anderson S, Thurman A, Chandra N, Jackson S, Asin S, Rollenhagen C, et al. Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women. Nutrients. 2020;12: pubmed publisher
Nishikawa G, Kawada K, Nakagawa J, Toda K, Ogawa R, Inamoto S, et al. Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression via CCR5. Cell Death Dis. 2019;10:264 pubmed publisher
Lin S, Sun L, Lyu X, Ai X, Du D, Su N, et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget. 2017;8:110426-110443 pubmed publisher
Fox J, Kasprowicz R, Hartley O, Signoret N. CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells. J Leukoc Biol. 2015;98:59-71 pubmed publisher
Yoshida N, Nishikori M, Izumi T, Imaizumi Y, Sawayama Y, Niino D, et al. Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis. Br J Haematol. 2013;161:214-23 pubmed publisher
Alonzo F, Kozhaya L, Rawlings S, Reyes Robles T, Dumont A, Myszka D, et al. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature. 2013;493:51-5 pubmed publisher
Weigt S, Elashoff R, Keane M, Strieter R, Gomperts B, Xue Y, et al. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am J Transplant. 2008;8:1512-22 pubmed publisher
Roulet V, Satie A, Ruffault A, Le Tortorec A, Denis H, Guist hau O, et al. Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro. Am J Pathol. 2006;169:2094-103 pubmed
Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, et al. CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes. AIDS Res Hum Retroviruses. 2006;22:1152-61 pubmed
Capelli A, Di Stefano A, Gnemmi I, Donner C. CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis. Eur Respir J. 2005;25:701-7 pubmed
Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, et al. CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell Signal. 2005;17:355-63 pubmed
Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, et al. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur J Immunol. 2004;34:3485-96 pubmed
Kieseier B, Tani M, Mahad D, Oka N, Ho T, Woodroofe N, et al. Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10. Brain. 2002;125:823-34 pubmed
Lee B, Sharron M, Blanpain C, Doranz B, Vakili J, Setoh P, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274:9617-26 pubmed

product information

master code :

MAB181

SKU :

MAB181-100

product name :

Human CCR5 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human CCR5 Antibody from R&D Systems is a mouse monoclonal antibody to CCR5. This antibody reacts with human,xenograft,hamster - cricetulus (chinese hamster). The Human CCR5 Antibody has been validated for the following applications: Functional Assay,Bioassay,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

CCR5

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

45523

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CCR5, Met1-Leu352, Accession # P51681

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Xenograft,Hamster - Cricetulus (Chinese Hamster)

specificity :

Can be used to detect CCR5 present on stimulated human PBMCs only after cells are fixed with 2% formaldehyde. It does not detect CCR5 on unfixed human PBMCs. It does not cross-react with CCR1, CCR2, or CCR3. For additional information regarding epitope specificity for this antibody and other R D Systems anti-human CCR5 antibodies, see Lee, B. et al., 1999, J. Biol. Chem. 274 :9617.

gene symbol :

CCR5

top caption :

CCR5 antibody in Human Dorsal Root Ganglia by Immunohistochemistry (IHC-P).

accessionNumbers :

P51681

applications :

Bioassay,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry

USD :

479 USD

alt names :

C-C CKR-5, C-C motif chemokine receptor 5 A159A, CCCKR5, CC-CKR-5FLJ78003, CCR5, CCR-5, CD195, CD195 antigen, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemr13, CKR5, CKR-5, HIV-1 fusion coreceptor, IDDM22CMKBR5C-C chemokine receptor type 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage