product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human LILRB3/CD85a/ILT5 Antibody
catalog :
MAB1806-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
222821
reactivity :
human, mouse
application :
western blot, neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 7
Reference
Wu G, Xu Y, Schultz R, Chen H, Xie J, Deng M, et al. LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis. Nat Cancer. 2021;2:1170-1184 pubmed publisher
Yeboah M, Papagregoriou C, Jones D, Chan H, Hu G, McPartlan J, et al. LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation. JCI Insight. 2020;5: pubmed publisher
Huang J, Burke P, Cung T, Pereyra F, Toth I, Walker B, et al. Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J Virol. 2010;84:9463-71 pubmed publisher
Bankey P, Banerjee S, Zucchiatti A, De M, Sleem R, Lin C, et al. Cytokine induced expression of programmed death ligands in human neutrophils. Immunol Lett. 2010;129:100-7 pubmed publisher
Pfistershammer K, Lawitschka A, Klauser C, Leitner J, Weigl R, Heemskerk M, et al. Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients. Blood. 2009;114:2323-32 pubmed publisher
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, et al. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. J Immunol. 2008;181:4742-51 pubmed
Masuda A, Nakamura A, Maeda T, Sakamoto Y, Takai T. Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J Exp Med. 2007;204:907-20 pubmed
product information
master code :
MAB1806
SKU :
MAB1806-100
product name :
Human LILRB3/CD85a/ILT5 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human LILRB3/CD85a/ILT5 Antibody from R&D Systems is a mouse monoclonal antibody to ILT5/CD85a/LILRB3. This antibody reacts with human,mouse. The Human LILRB3/CD85a/ILT5 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,CyTOF-ready.
target :
LILRB3/CD85a/ILT5
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
222821
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human LILRB3/CD85a/ILT5, Gly24-Glu443, Accession # AAB68668
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human LILRB3/CD85a/ILT5 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) ILT1, rhILT2, rhILT3, rhILT4, rhILT6, rhILT7 or rhILT11 is observed.
gene symbol :
LILRB3
top caption :
Detection of LILRB3/CD85a/ILT5 antibody in Human PBMCs antibody by Flow Cytometry.
accessionNumbers :
AAB68668
applications :
Flow Cytometry,Western Blot,Neutralization,CyTOF-ready
USD :
459 USD
alt names :
CD85 antigen-like family member A, CD85a, CD85a antigen, HL9Immunoglobulin-like transcript 5, ILT5, ILT-5, ILT5CD85a, Leukocyte immunoglobulin-like receptor 3, leukocyte immunoglobulin-like receptor subfamily B member 3, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), LIR3, LIR3CD85A, LIR-3MGC138403, member 3, Monocyte inhibitory receptor HL9, PIRB
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.