product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CCR5 Antibody
catalog :
MAB1802-100
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CTC5
reactivity :
human
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
R&D Systems product webpage
citations: 10
Reference
Branscome H, Khatkar P, Al Sharif S, Yin D, Jacob S, Cowen M, et al. Retroviral infection of human neurospheres and use of stem Cell EVs to repair cellular damage. Sci Rep. 2022;12:2019 pubmed publisher
Weichseldorfer M, Tagaya Y, Reitz M, DeVico A, Latinovic O. Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies. J Transl Med. 2022;20:39 pubmed publisher
Jacquemard C, Koensgen F, Colin P, Lagane B, Kellenberger E. Modeling of CCR5 Recognition by HIV-1 gp120: How the Viral Protein Exploits the Conformational Plasticity of the Coreceptor. Viruses. 2021;13: pubmed publisher
Colin P, Zhou Z, Staropoli I, Garcia Perez J, Gasser R, Armani Tourret M, et al. CCR5 structural plasticity shapes HIV-1 phenotypic properties. PLoS Pathog. 2018;14:e1007432 pubmed publisher
Lin S, Sun L, Lyu X, Ai X, Du D, Su N, et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget. 2017;8:110426-110443 pubmed publisher
Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, et al. A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. PLoS ONE. 2015;10:e0128381 pubmed publisher
Fox J, Kasprowicz R, Hartley O, Signoret N. CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells. J Leukoc Biol. 2015;98:59-71 pubmed publisher
Tilton J, Wilen C, Didigu C, Sinha R, Harrison J, Agrawal Gamse C, et al. A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5. J Virol. 2010;84:10863-76 pubmed publisher
Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen I, et al. Divergent effects of hypoxia on dendritic cell functions. Blood. 2008;112:3723-34 pubmed publisher
Lee B, Sharron M, Blanpain C, Doranz B, Vakili J, Setoh P, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274:9617-26 pubmed
product information
brand :
R&D Systems
master code :
MAB1802
SKU :
MAB1802-100
product name :
Human CCR5 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human CCR5 Antibody from R&D Systems is a mouse monoclonal antibody to CCR5. This antibody reacts with human. The Human CCR5 Antibody has been validated for the following applications: Competitive Binding Assay,ELISA Development,Flow Cytometry,Western Blot,Immunocytochemistry,CyTOF-ready.
target :
CCR5
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
CTC5
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot, Flow Cytometry 0.25 ug/10^6 cells, CyTOF-ready
host :
Mouse
immunogen :
CHO Chinese hamster ovary cell line transfected with human CCR5
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human CCR5 in Western blots. For additional information regarding epitope specificity for this antibody and other R D Systems anti-human CCR5 antibodies, see Reference 1.
gene symbol :
CCR5
top caption :
Detection of CCR5 antibody in Human Peripheral Blood Lymphocytes antibody by Flow Cytometry.
applications :
CyTOF-ready,Competitive Binding Assay,ELISA Development,Flow Cytometry,Western Blot,Immunocytochemistry
USD :
479 USD
alt names :
C-C CKR-5, C-C motif chemokine receptor 5 A159A, CCCKR5, CC-CKR-5FLJ78003, CCR5, CCR-5, CD195, CD195 antigen, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemr13, CKR5, CKR-5, HIV-1 fusion coreceptor, IDDM22CMKBR5C-C chemokine receptor type 5
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.