Human CCR5 Antibody | R&D Systems MAB180-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR5 Antibody

catalog :

MAB180-100

quantity :

100 ug (also 25 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

45502

reactivity :

human

application :

western blot, flow cytometry

more info or order :

R&D Systems product webpage

citations: 8

Reference
Macarie R, Vadana M, Ciortan L, Tucureanu M, Ciobanu A, Vinereanu D, et al. The expression of MMP-1 and MMP-9 is up-regulated by smooth muscle cells after their cross-talk with macrophages in high glucose conditions. J Cell Mol Med. 2018;22:4366-4376 pubmed publisher
Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, et al. A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. PLoS ONE. 2015;10:e0128381 pubmed publisher
Fox J, Kasprowicz R, Hartley O, Signoret N. CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells. J Leukoc Biol. 2015;98:59-71 pubmed publisher
Carrega P, Bonaccorsi I, Di Carlo E, Morandi B, Paul P, Rizzello V, et al. CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph. J Immunol. 2014;192:3805-15 pubmed publisher
Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S. Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation. Blood. 2009;113:5157-66 pubmed publisher
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, et al. CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell Signal. 2005;17:355-63 pubmed
Lee B, Sharron M, Blanpain C, Doranz B, Vakili J, Setoh P, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274:9617-26 pubmed

product information

master code :

MAB180

SKU :

MAB180-100

product name :

Human CCR5 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human CCR5 Antibody from R&D Systems is a mouse monoclonal antibody to CCR5. This antibody reacts with human. The Human CCR5 Antibody has been validated for the following applications: Functional Assay,ELISA Development,Flow Cytometry,Western Blot,CyTOF-ready.

target :

CCR5

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

45502

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CCR5, Met1-Leu352, Accession # P51681

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Specifically stains human CCR5 transfectants but not the parental cell line as detected by flow cytometry. It has also been shown to react with a CCR5/CCR2 chimera (5222) containing the amino-terminal domain of CCR5. However, this antibody does not react with CCR5 present on unfixed stimulated human PBMCs by flow cytometry. For additional information regarding epitope specificity for this antibody and other R DáSystems anti-human CCR5 antibodies, see Lee,áB. etáal ., 1999, J.áBiol. Chem. 274 :9617.

gene symbol :

CCR5

accessionNumbers :

P51681

applications :

ELISA Development,Flow Cytometry,Western Blot,CyTOF-ready

USD :

459 USD

alt names :

C-C CKR-5, C-C motif chemokine receptor 5 A159A, CCCKR5, CC-CKR-5FLJ78003, CCR5, CCR-5, CD195, CD195 antigen, chemokine (C-C motif) receptor 5, chemokine receptor CCR5, chemr13, CKR5, CKR-5, HIV-1 fusion coreceptor, IDDM22CMKBR5C-C chemokine receptor type 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage