product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse IL-28A/B (IFN-lambda 2/3) Antibody
catalog :
MAB17892-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
244716
reactivity :
human
application :
ELISA, neutralization
more info or order :
R&D Systems product webpage
citations: 9
Reference
Gaur K, Asuru T, Srivastava M, Singh N, Purushotham N, Poojary B, et al. 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Mol Med. 2024;16:2376-2401 pubmed publisher
De M, Sukla S, Bharatiya S, Keshri S, Roy D, Roy S, et al. IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans. Infect Immun. 2024;92:e0050423 pubmed publisher
Latha K, Patel Y, Rao S, Watford W. The Influenza-Induced Pulmonary Inflammatory Exudate in Susceptible Tpl2-Deficient Mice Is Dictated by Type I IFN Signaling. Inflammation. 2023;46:322-341 pubmed publisher
Gibson A, Sateriale A, Dumaine J, Engiles J, Pardy R, Gullicksrud J, et al. A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathog. 2022;18:e1010003 pubmed publisher
Zhan Y, Kong I, Chopin M, Macri C, Zhang J, Xie J, et al. Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity. Immunol Cell Biol. 2020;98:203-214 pubmed publisher
Ferguson S, Foster D, Sherry B, Magness S, Nielsen D, Gookin J. Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection. Cell Mol Gastroenterol Hepatol. 2019;8:1-20 pubmed publisher
Broggi A, Tan Y, Granucci F, Zanoni I. IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function. Nat Immunol. 2017;18:1084-1093 pubmed publisher
Crotta S, Davidson S, Mahlakõiv T, Desmet C, Buckwalter M, Albert M, et al. Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathog. 2013;9:e1003773 pubmed publisher
Rynda A, Maddaloni M, Ochoa Repáraz J, Callis G, Pascual D. IL-28 supplants requirement for T(reg) cells in protein sigma1-mediated protection against murine experimental autoimmune encephalomyelitis (EAE). PLoS ONE. 2010;5:e8720 pubmed publisher
product information
master code :
MAB17892
SKU :
MAB17892-100
product name :
Mouse IL-28A/B (IFN-lambda 2/3) Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Mouse IL-28A/B (IFN-lambda 2/3) Antibody from R&D Systems is a rat monoclonal antibody to IL-28A/B (IFN-lambda 2/3). This antibody reacts with mouse,porcine. The Mouse IL-28A/B (IFN-lambda 2/3) Antibody has been validated for the following applications: In vivo assay,Neutralization,ELISA Development,ELISA Capture,ELISA Capture (Matched Antibody Pair).
target :
IL-28A/B (IFN-lambda 2/3)
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
244716
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
E. coli -derived recombinant mouse IL-28B/IFN-lambda 3, Asp20-Val193, Accession # Q8CGK6
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse,Porcine
specificity :
Detects mouse IL-28B/IFN-lambda 3 in ELISAs. In sandwich immunoassays, 100% cross-reactivity with recombinant mouse IL-28A/IFN-lambda 2 and no cross-reactivity with recombinant human (rh) IL-28A or rhIL-29 is observed.
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
IL-28B/IFN-?3 Inhibition of EMCV-induced Cytopathy and Neutralization by Mouse IL-28B/IFN-?3 Antibody.
accessionNumbers :
Q8CGK6
applications :
In vivo assay,Neutralization,ELISA Development,ELISA Capture,ELISA Capture (Matched Antibody Pair)
USD :
489 USD
alt names :
IFNl2, IFNlambda 2, IFN-lambda 2, IFN-lambda 3, IL28A, IL-28A, IL28B, interferon lambda 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.