Human IL-17RA/IL-17R Antibody | R&D Systems MAB177 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-17RA/IL-17R Antibody

catalog :

MAB177

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

133617

reactivity :

human

application :

western blot, neutralization, flow cytometry

citations: 13

Reference
Wu J, Guo J, Cao Q, Wang Y, Chen J, Wang Z, et al. Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway. Oncol Lett. 2017;13:770-776 pubmed publisher
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S. Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. Eur J Immunol. 2016;46:440-5 pubmed publisher
Bellini A, Marini M, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol. 2012;5:140-9 pubmed publisher
Ramirez Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, et al. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol. 2011;12:1159-66 pubmed publisher
Chang Y, Al Alwan L, Risse P, Roussel L, Rousseau S, Halayko A, et al. TH17 cytokines induce human airway smooth muscle cell migration. J Allergy Clin Immunol. 2011;127:1046-53.e1-2 pubmed publisher
Corrigan C, Wang W, Meng Q, Fang C, Wu H, Reay V, et al. T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci U S A. 2011;108:1579-84 pubmed publisher
Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, et al. Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int J Cancer. 2009;125:1092-101 pubmed publisher
Shahrara S, Pickens S, Dorfleutner A, Pope R. IL-17 induces monocyte migration in rheumatoid arthritis. J Immunol. 2009;182:3884-91 pubmed publisher
Eid R, Rao D, Zhou J, Lo S, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-32 pubmed publisher
Zrioual S, Toh M, Tournadre A, Zhou Y, Cazalis M, Pachot A, et al. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J Immunol. 2008;180:655-63 pubmed
Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, et al. CD molecules 2006--human cell differentiation molecules. J Immunol Methods. 2007;319:1-5 pubmed
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175:6177-89 pubmed

product information

brand :

R&D Systems

master code :

MAB177

SKU :

MAB177-100

product name :

Human IL-17RA/IL-17R Antibody

description :

The Human IL-17RA/IL-17R Antibody from R&D Systems is a mouse monoclonal antibody to IL-17RA/IL-17R. This antibody reacts with human. The Human IL-17RA/IL-17R Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Neutralization, CyTOF-ready, Knockout Validated.

target :

IL-17RA/IL-17R

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

133617

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-17 RA/IL-17 R, Leu33-Trp320, Accession # Q96F46

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-17 RA/IL-17 R in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) IL-17 R, rmIL-17B R, or recombinant human IL-17B R is observed. In Western blots, no cross-reactivity with rmIL-17 R is observed

gene symbol :

IL17RA

details of functionality :

ActivityAssaywCitation not found None None None None

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB177

accessionNumbers :

Q96F46

applications :

Western Blot, Flow Cytometry, Neutralization, CyTOF-ready, Knockout Validated

2020 USD :

339

2021 USD :

359 USD

alt names :

CD217, CD217 antigen, Cdw217, CDw217interleukin 17 receptor, hIL-17R, IL-17 R, IL-17 RA, IL-17 receptor A, IL17RA, IL-17RAMGC10262, IL17Rinterleukin-17 receptor A, interleukin 17 receptor A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.