Human IL-17RA/IL-17R Antibody | R&D Systems MAB177-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-17RA/IL-17R Antibody

catalog :

MAB177-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

133617

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 20

Reference
Sigutova V, Xiang W, Regensburger M, Winner B, Prots I. Alpha-synuclein fine-tunes neuronal response to pro-inflammatory cytokines. Brain Behav Immun. 2024;122:216-230 pubmed publisher
Margetts G, Kleidonas S, Zaibi N, Zaibi M, Edwards K. Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. BMC Complement Med Ther. 2022;22:131 pubmed publisher
Bolt J, van Kuijk A, Teunissen M, van der Coelen D, Aarrass S, Gerlag D, et al. Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis. Biomedicines. 2022;10: pubmed publisher
Gatsiou A, Sopova K, Tselepis A, Stellos K. Interleukin-17A Triggers the Release of Platelet-Derived Factors Driving Vascular Endothelial Cells toward a Pro-Angiogenic State. Cells. 2021;10: pubmed publisher
Ramirez Carrozzi V, Ota N, Sambandam A, Wong K, Hackney J, Martinez Martin N, et al. Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes. J Immunol. 2019;202:1935-1941 pubmed publisher
Wu J, Guo J, Cao Q, Wang Y, Chen J, Wang Z, et al. Autophagy impacts on oxaliplatin-induced hepatocarcinoma apoptosis via the IL-17/IL-17R-JAK2/STAT3 signaling pathway. Oncol Lett. 2017;13:770-776 pubmed publisher
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126:495-508 pubmed
Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S. Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. Eur J Immunol. 2016;46:440-5 pubmed publisher
Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, et al. Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific VÎ³2VÎ´2 T cells after Mycobacterium tuberculosis infection or vaccination. Eur J Immunol. 2015;45:442-51 pubmed publisher
Bellini A, Marini M, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol. 2012;5:140-9 pubmed publisher
Ramirez Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, et al. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol. 2011;12:1159-66 pubmed publisher
Chang Y, Al Alwan L, Risse P, Roussel L, Rousseau S, Halayko A, et al. TH17 cytokines induce human airway smooth muscle cell migration. J Allergy Clin Immunol. 2011;127:1046-53.e1-2 pubmed publisher
Corrigan C, Wang W, Meng Q, Fang C, Wu H, Reay V, et al. T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci U S A. 2011;108:1579-84 pubmed publisher
Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, et al. Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma. Int J Cancer. 2009;125:1092-101 pubmed publisher
Shahrara S, Pickens S, Dorfleutner A, Pope R. IL-17 induces monocyte migration in rheumatoid arthritis. J Immunol. 2009;182:3884-91 pubmed publisher
Eid R, Rao D, Zhou J, Lo S, Ranjbaran H, Gallo A, et al. Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation. 2009;119:1424-32 pubmed publisher
Zrioual S, Toh M, Tournadre A, Zhou Y, Cazalis M, Pachot A, et al. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J Immunol. 2008;180:655-63 pubmed
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product information

brand :

R&D Systems

master code :

MAB177

SKU :

MAB177-100

product name :

Human IL-17RA/IL-17R Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human IL-17RA/IL-17R Antibody from R&D Systems is a mouse monoclonal antibody to IL-17RA/IL-17R. This antibody reacts with human,primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque). The Human IL-17RA/IL-17R Antibody has been validated for the following applications: Immunocytochemistry,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,CyTOF-ready,Knockout Validated.

target :

IL-17RA/IL-17R

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

133617

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Neutralization, CyTOF-ready, Knockout Validated 0.25 ug/10^6 cells

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-17 RA/IL-17 R, Leu33-Trp320, Accession # Q96F46

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)

specificity :

Detects human IL-17 RA/IL-17 R in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) IL-17 R, rmIL-17B R, or recombinant human IL-17B R is observed. In Western blots, no cross-reactivity with rmIL-17 R is observed

gene symbol :

IL17RA

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

Antibody validation :

Knockout/Knockdown

top caption :

Detection of IL-17 R antibody in K562 Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

Q96F46

applications :

CyTOF-ready,Knockout Validated,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

479 USD

alt names :

CD217, CD217 antigen, Cdw217, CDw217interleukin 17 receptor, hIL-17R, IL-17 R, IL-17 RA, IL-17 receptor A, IL17RA, IL-17RAMGC10262, IL17Rinterleukin-17 receptor A, interleukin 17 receptor A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage