Human CXCR4 Antibody | R&D Systems MAB173-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR4 Antibody

catalog :

MAB173-100

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

44717

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 29

Reference
Garc xed a Cuesta E, Mart xed nez P, Selvaraju K, Ulltj xe4 rn G, G xf3 mez Pozo A, D Agostino G, et al. Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain. elife. 2024;13: pubmed publisher
Tundidor I, Seijo Vila M, Blasco Benito S, Rubert Hern xe1 ndez M, Ad xe1 mez S, Andradas C, et al. Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer. Nat Commun. 2023;14:3130 pubmed publisher
Shamshirgaran Y, Jonebring A, Svensson A, Leefa I, Bohlooly Y M, Firth M, et al. Rapid target validation in a Cas9-inducible hiPSC derived kidney model. Sci Rep. 2021;11:16532 pubmed publisher
Armani Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube Ferrieu V, Benureau Y, et al. Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. PLoS Pathog. 2021;17:e1009526 pubmed publisher
Subramani P, Vartak Sharma N, Sreekumar S, Mathur P, Nayer B, Dakhore S, et al. Plasmodium vivax liver stage assay platforms using Indian clinical isolates. Malar J. 2020;19:214 pubmed publisher
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, et al. Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2020;117:7305-7316 pubmed publisher
Ahmed M, Basheer H, Ayuso J, Ahmet D, Mazzini M, Patel R, et al. Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines. Sci Rep. 2017;7:1075 pubmed publisher
Desplantes R, Leveque C, Müller B, Lotierzo M, Ferracci G, Popoff M, et al. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor. Sci Rep. 2017;7:1032 pubmed publisher
Li P, Deng J, Wei X, Jayasuriya C, Zhou J, Chen Q, et al. Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1? and MMP-13. Mol Med Rep. 2016;14:1475-82 pubmed publisher
Huang K, Kiefer C, Kamal A. Novel role for NFAT3 in ERK-mediated regulation of CXCR4. PLoS ONE. 2014;9:e115249 pubmed publisher
Carrega P, Bonaccorsi I, Di Carlo E, Morandi B, Paul P, Rizzello V, et al. CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph. J Immunol. 2014;192:3805-15 pubmed publisher
Yin X, Johns S, Kim D, Mikulski Z, SALANGA C, Handel T, et al. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014;192:2133-42 pubmed publisher
Duluc D, Gannevat J, Anguiano E, Zurawski S, Carley M, Boreham M, et al. Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol. 2013;6:626-38 pubmed publisher
Kulbe H, Chakravarty P, Leinster D, Charles K, Kwong J, Thompson R, et al. A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Cancer Res. 2012;72:66-75 pubmed publisher
Rahimi M, Toth T, Tang C. CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells. Cancer Lett. 2011;306:43-51 pubmed publisher
Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes H, et al. CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS ONE. 2010;5:e9175 pubmed publisher
Rahimi M, George J, Tang C. EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. Int J Cancer. 2010;126:1850-1860 pubmed publisher
Kollmar O, Rupertus K, Scheuer C, Nickels R, Haberl G, Tilton B, et al. CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Int J Cancer. 2010;126:1302-15 pubmed publisher
Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, et al. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med. 2009;206:249-58 pubmed publisher
Hansson M, Hermansson M, Svensson H, Elfvin A, Hansson L, Johnsson E, et al. CCL28 is increased in human Helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin A-secreting cells. Infect Immun. 2008;76:3304-11 pubmed publisher
Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, et al. pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J Pathol. 2008;214:464-71 pubmed publisher
Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
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product information

brand :

R&D Systems

master code :

MAB173

SKU :

MAB173-100

product name :

Human CXCR4 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human CXCR4 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR4. This antibody reacts with feline,human,mouse. The Human CXCR4 Antibody has been validated for the following applications: Flow Cytometry,Blocking,Binding Assay,Western Blot,Surface Plasmon Resonance,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready.

target :

CXCR4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

44717

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, Neutralization 1-5 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

3T3 cells transfected with human CXCR4

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Feline,Human,Mouse

specificity :

Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.

gene symbol :

CXCR4

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Chemotaxis Induced by CXCL12/SDF-1a and Neutralization by Human CXCR4 Antibody.

applications :

CyTOF-ready,Blocking,Binding Assay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Surface Plasmon Resonance,Neutralization,Immunocytochemistry

USD :

489 USD

alt names :

CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage