This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse TREM2 Antibody
catalog :
MAB17291
quantity :
100 ug (also 25 ug, 500 ug)
price :
369 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
237920
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
citations: 10
Published Application/Species/Sample/DilutionReference
  • ELISA; mouse; 1:1000; loading ...; fig 6b, s2b
Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. 2020;140:513-534 pubmed publisher
Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed publisher
Russo M, Fiore N, van Vreden C, Bailey D, Santarelli D, McGuire H, et al. Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. J Neuroinflammation. 2019;16:63 pubmed publisher
Garcia Reitboeck P, Phillips A, Piers T, Villegas Llerena C, Butler M, Mallach A, et al. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis. Cell Rep. 2018;24:2300-2311 pubmed publisher
Varnum M, Clayton K, Yoshii Kitahara A, Yonemoto G, Koro L, Ikezu S, et al. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017;292:10651-10663 pubmed publisher
Alves S, Churlaud G, Audrain M, Michaelsen Preusse K, Fol R, Souchet B, et al. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain. 2017;140:826-842 pubmed publisher
Savage J, Jay T, Goduni E, Quigley C, Mariani M, Malm T, et al. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. J Neurosci. 2015;35:6532-43 pubmed publisher
Wu K, Byers D, Jin X, Agapov E, Alexander Brett J, Patel A, et al. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med. 2015;212:681-97 pubmed publisher
Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim J, Hsieh C, et al. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015;35:3384-96 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB17291
SKU :
MAB17291-100
product name :
Human/Mouse TREM2 Antibody
description :
The Human/Mouse TREM2 Antibody from R&D Systems is a rat monoclonal antibody to TREM2. This antibody reacts with human, mouse. The Human/Mouse TREM2 Antibody has been validated for the following applications: Flow Cytometry, ELISA, Immunocytochemistry, CyTOF-ready, Knockout Validated.
target :
TREM2
category :
Primary Antibodies
unit size :
100 ug (also 25 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
237920
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse TREM2, extracellular domain, Accession # Q99NH8
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human, Mouse
specificity :
Detects human and mouse TREM2 in direct ELISAs. Stains TREM2 transfectants but not TREM1 transfectants in flow cytometry. In sandwich ELISAs, detects mouse TREM2 when paired with a mouse TREM2 detection antibody.
gene symbol :
TREM2
details of functionality :
ActivityAssaywCitation not found None None None None
catalog number base :
MAB17291
accessionNumbers :
Q99NH8
applications :
Flow Cytometry, ELISA, Immunocytochemistry, CyTOF-ready, Knockout Validated
2020 USD :
339
2021 USD :
369 USD
alt names :
PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.