Human/Mouse TREM2 Antibody | R&D Systems MAB17291-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse TREM2 Antibody

catalog :

MAB17291-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

237920

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 35

Reference
Pierro E, Cottam M, An H, Lehmann B, Pietenpol J, Wellen K, et al. Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations. bioRxiv. 2024;: pubmed publisher
Arsenault R, Marshall S, Salois P, Li Q, Zhang W. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway. Biology (Basel). 2024;13: pubmed publisher
Chen J, Zhu T, Jiang G, Zeng Q, Li Z, Huang X. Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer. Mol Cancer. 2023;22:131 pubmed publisher
Yin T, D ADAMIO L. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv. 2023;: pubmed publisher
Gao H, Di J, Clausen B, Wang N, Zhu X, Zhao T, et al. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell Rep. 2023;42:112629 pubmed publisher
Thu V, Hoang T, Kim J. 1,25-Dihydroxy Vitamin D3 Facilitates the M2 Polarization and β-Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner. Biomed Res Int. 2023;2023:3483411 pubmed publisher
Su P, Zhang J, Wu J, Chen H, Luo W, Hu M. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicol Environ Saf. 2023;260:115058 pubmed publisher
Haensel D, Dániel B, Gaddam S, Pan C, Fabo T, Bjelajac J, et al. Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche. Nat Commun. 2023;14:2685 pubmed publisher
Moutinho M, Coronel I, Tsai A, Di Prisco G, Pennington T, Atwood B, et al. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome Med. 2023;15:11 pubmed publisher
Shu X, Wei C, Tu W, Zhong K, Qi S, Wang A, et al. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Rep. 2023;42:112133 pubmed publisher
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park J, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nat Neurosci. 2023;26:416-429 pubmed publisher
Choi C, Kim H, Oh J, Park C, Kim M, Kim C, et al. DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity. Life Sci Alliance. 2023;6: pubmed publisher
Thomas A, Lehn M, Janssen E, Hildeman D, Chougnet C. Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Sci Rep. 2022;12:19471 pubmed publisher
Vahsen B, Gray E, Candalija A, Cramb K, Scaber J, Dafinca R, et al. Human iPSC co-culture model to investigate the interaction between microglia and motor neurons. Sci Rep. 2022;12:12606 pubmed publisher
Sanjay -, Shin J, Park M, Lee H. Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Mol Neurobiol. 2022;59:5135-5148 pubmed publisher
Cosker K, Mallach A, Limaye J, Piers T, Staddon J, Neame S, et al. Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome. Sci Rep. 2021;11:13316 pubmed publisher
Munn C, Burton S, Dickerson S, Bakshy K, Strouse A, Rajesh D. Generation of cryopreserved macrophages from normal and genetically engineered human pluripotent stem cells for disease modelling. PLoS ONE. 2021;16:e0250107 pubmed publisher
Chen H, Chen C, Mandhani N, Short Miller J, Smucker M, Sun Y, et al. Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. J Neurosci. 2020;40:9386-9400 pubmed publisher
Korvatska O, Kiianitsa K, Ratushny A, Matsushita M, Beeman N, Chien W, et al. Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain. Front Immunol. 2020;11:559342 pubmed publisher
Wang Y, Shi Y, Huang Y, Liu W, Cai G, Huang S, et al. Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model. J Neuroinflammation. 2020;17:311 pubmed publisher
Heckmann B, Teubner B, Boada Romero E, Tummers B, Guy C, Fitzgerald P, et al. Noncanonical function of an autophagy protein prevents spontaneous Alzheimer's disease. Sci Adv. 2020;6:eabb9036 pubmed publisher
Andreone B, Przybyla L, Llapashtica C, Rana A, Davis S, van Lengerich B, et al. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nat Neurosci. 2020;23:927-938 pubmed publisher
Heckmann B, Teubner B, Tummers B, Boada Romero E, Harris L, Yang M, et al. LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer's Disease. Cell. 2019;: pubmed publisher
Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed publisher
Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher
Russo M, Fiore N, van Vreden C, Bailey D, Santarelli D, McGuire H, et al. Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome. J Neuroinflammation. 2019;16:63 pubmed publisher
Kurisu K, Zheng Z, Kim J, Shi J, Kanoke A, Liu J, et al. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. J Cereb Blood Flow Metab. 2019;39:1906-1918 pubmed publisher
Garcia Reitboeck P, Phillips A, Piers T, Villegas Llerena C, Butler M, Mallach A, et al. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis. Cell Rep. 2018;24:2300-2311 pubmed publisher
Kim S, Mun B, Lee S, Joh Y, Lee H, Ji K, et al. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Sci Rep. 2017;7:11118 pubmed publisher
Raj D, Yin Z, Breur M, Doorduin J, Holtman I, Olah M, et al. Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. Front Mol Neurosci. 2017;10:206 pubmed publisher
Varnum M, Clayton K, Yoshii Kitahara A, Yonemoto G, Koro L, Ikezu S, et al. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017;292:10651-10663 pubmed publisher
Alves S, Churlaud G, Audrain M, Michaelsen Preusse K, Fol R, Souchet B, et al. Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Brain. 2017;140:826-842 pubmed publisher
Savage J, Jay T, Goduni E, Quigley C, Mariani M, Malm T, et al. Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease. J Neurosci. 2015;35:6532-43 pubmed publisher
Wu K, Byers D, Jin X, Agapov E, Alexander Brett J, Patel A, et al. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. J Exp Med. 2015;212:681-97 pubmed publisher
Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim J, Hsieh C, et al. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015;35:3384-96 pubmed publisher

product information

master code :

MAB17291

SKU :

MAB17291-100

product name :

Human/Mouse TREM2 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human/Mouse TREM2 Antibody from R&D Systems is a rat monoclonal antibody to TREM2. This antibody reacts with human,mouse,n/a,rat,transgenic mouse. The Human/Mouse TREM2 Antibody has been validated for the following applications: Immunohistochemistry,ELISA Detection,In vivo assay,CyTof,ELISA Development (Capture),Receptor Recycling,Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA,CyTOF-ready,Knockout Validated.

target :

TREM2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

237920

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TREM2, extracellular domain, Accession # Q99NH8

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,N/A,Rat,Transgenic Mouse

specificity :

Detects human and mouse TREM2 in direct ELISAs. Stains TREM2 transfectants but not TREM1 transfectants in flow cytometry. In sandwich ELISAs, detects mouse TREM2 when paired with a mouse TREM2 detection antibody.

gene symbol :

TREM2

Antibody validation :

Knockout/Knockdown

top caption :

Detection of TREM2 antibody in RAW 264.7 Mouse Cell Line antibody by Flow Cytometry.

accessionNumbers :

Q99NH8

applications :

In vivo assay,Immunohistochemistry,CyTof,ELISA Development (Capture),Receptor Recycling,Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture,ELISA Detection,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA,CyTOF-ready,Knockout Validated

USD :

499 USD

alt names :

PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage