Mouse TREM2 Antibody | R&D Systems MAB1729-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse TREM2 Antibody

catalog :

MAB1729-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

237916

reactivity :

human, mouse

application :

western blot, ELISA

more info or order :

R&D Systems product webpage

citations: 10

Reference
You S, Brase L, Filipello F, Iyer A, Del Aguila J, He J, et al. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state. medRxiv. 2023;: pubmed publisher
Qiao W, Chen Y, Zhong J, Madden B, Charlesworth C, Martens Y, et al. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Mol Neurodegener. 2023;18:8 pubmed publisher
Oestereich F, Yousefpour N, Yang E, Ph xe9 nix J, Nezhad Z, Nitu A, et al. The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain. J Lipid Res. 2022;63:100260 pubmed publisher
Kotredes K, Oblak A, Pandey R, Lin P, Garceau D, Williams H, et al. Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H. Front Aging Neurosci. 2021;13:735524 pubmed publisher
Jadhav V, Lin P, Pennington T, Di Prisco G, Jannu A, Xu G, et al. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Mol Neurodegener. 2020;15:62 pubmed publisher
Thornton P, Sevalle J, Deery M, Fraser G, Zhou Y, Ståhl S, et al. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. EMBO Mol Med. 2017;9:1366-1378 pubmed publisher
Kleinberger G, Brendel M, Mracskó É, Wefers B, Groeneweg L, Xiang X, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J. 2017;36:1837-1853 pubmed publisher
Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, et al. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Front Aging Neurosci. 2017;9:8 pubmed publisher
Alves S, Marais T, Biferi M, Furling D, Marinello M, El Hachimi K, et al. Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins. Mol Neurodegener. 2016;11:58 pubmed publisher
Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H. Osteoprotection by semaphorin 3A. Nature. 2012;485:69-74 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB1729

SKU :

MAB1729-100

product name :

Mouse TREM2 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Mouse TREM2 Antibody from R&D Systems is a rat monoclonal antibody to TREM2. This antibody reacts with mouse. The Mouse TREM2 Antibody has been validated for the following applications: ELISA Development,ELISA Development (Detection),Western Blot,ELISA Capture.

target :

TREM2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

237916

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TREM2, Leu19-Pro168, Accession # Q99NH8

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse TREM2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) TREM1, recombinant human TREM2, or rmTREM3 is observed.

gene symbol :

TREM2

accessionNumbers :

Q99NH8

applications :

ELISA Development,ELISA Development (Detection),Western Blot,ELISA Capture

USD :

479 USD

alt names :

PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage