Human CXCR4 Antibody | R&D Systems MAB172 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR4 Antibody

catalog :

MAB172

quantity :

100 ug (also 25 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

44716

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

citations: 47

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 20 ug/ml; loading ...; fig 5a immunohistochemistry - paraffin section; human; 25 ug/ml; loading ...; fig 1 immunocytochemistry; human; 25 ug/ml; loading ...; fig 2b	Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
immunohistochemistry; human; loading ...; fig 2 western blot; human; loading ...; fig 5a	Zhu Q, Luo R, Gu J, Hou Y, Chen Z, Xu F, et al. High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma. J Cancer. 2020;11:810-818 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 3	González I, Bauer P, Chapman W, Alipour Z, Rais R, Liu J, et al. Clinicopathologic determinants of pathologic treatment response in neoadjuvant treated rectal adenocarcinoma. Ann Diagn Pathol. 2020;45:151452 pubmed publisher
immunohistochemistry - paraffin section; human; 1:500; loading ...; fig e1f	Ramachandran P, Dobie R, Wilson Kanamori J, Dora E, Henderson B, Luu N, et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature. 2019;575:512-518 pubmed publisher
immunohistochemistry - paraffin section; human; 1:128,000; loading ...; fig 1c, 2, 5, 6	van Ipenburg J, de Waard N, Naus N, Jager M, Paridaens D, Verdijk R. Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions. Invest Ophthalmol Vis Sci. 2019;60:2950-2957 pubmed publisher
	Giampieri R, Piva F, Occhipinti G, Bittoni A, Righetti A, Pagliaretta S, et al. Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy. PLoS ONE. 2019;14:e0215990 pubmed publisher
	Del Molino Del Barrio I, Wilkins G, Meeson A, Ali S, Kirby J. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int J Mol Sci. 2018;19: pubmed publisher
	Yoon J, Kim Y, Kwon S, Kim M, Kim Y, Kim J, et al. Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo. Theranostics. 2018;8:4620-4632 pubmed publisher
	Chau M, Deveau T, Gu X, Kim Y, Xu Y, Yu S, et al. Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice. BMC Neurosci. 2018;19:20 pubmed publisher
	Kitawaki Y, Nakamura Y, Kubota Nakayama F, Yamazaki Y, Miki Y, Hata S, et al. Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. Hum Pathol. 2018;77:88-97 pubmed publisher
	Tang W, Chen Y, Wang X, Chen Y, Zhang J, Lin Z. Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncol Lett. 2018;15:2501-2507 pubmed publisher
	Zhang J, Liu C, Mo X, Shi H, Li S. Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer. Oncol Lett. 2018;15:1771-1776 pubmed publisher
	Fareh M, Almairac F, Turchi L, Burel Vandenbos F, Paquis P, Fontaine D, et al. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth. Cell Death Dis. 2017;8:e2713 pubmed publisher
	Hira V, Verbovšek U, Breznik B, Srdič M, Novinec M, Kakar H, et al. Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:594-603 pubmed publisher
	Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, et al. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J Virol. 2016;90:10642-10659 pubmed publisher
	Wescott M, Kufareva I, Paes C, Goodman J, Thaker Y, Puffer B, et al. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016;113:9928-33 pubmed publisher
	Mercurio L, Ajmone Cat M, Cecchetti S, Ricci A, Bozzuto G, Molinari A, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016;35:55 pubmed publisher
	Coke C, Scarlett K, Chetram M, Jones K, Sandifer B, Davis A, et al. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression. J Biol Chem. 2016;291:9991-10005 pubmed publisher
	Pilling D, Cox N, Vakil V, Verbeek J, Gomer R. The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS ONE. 2015;10:e0119709 pubmed publisher
	Hu W, Liu Y, Zhou W, Si L, Ren L. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro. PLoS ONE. 2014;9:e99056 pubmed publisher
	Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, et al. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res. 2014;20:3422-33 pubmed publisher
	Jarajapu Y, Hazra S, Segal M, Li Calzi S, LiCalzi S, Jadhao C, et al. Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms. PLoS ONE. 2014;9:e93965 pubmed publisher
	Zgraggen S, Huggenberger R, Kerl K, Detmar M. An important role of the SDF-1/CXCR4 axis in chronic skin inflammation. PLoS ONE. 2014;9:e93665 pubmed publisher
	Yin X, Johns S, Kim D, Mikulski Z, SALANGA C, Handel T, et al. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014;192:2133-42 pubmed publisher
	Hoque M, Windus L, Lovitt C, Avery V. PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture. PLoS ONE. 2013;8:e79865 pubmed publisher
	Brennecke P, Arlt M, Muff R, Campanile C, Gvozdenović A, Husmann K, et al. Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice. PLoS ONE. 2013;8:e74045 pubmed publisher
	Gassenmaier M, Chen D, Buchner A, Henkel L, Schiemann M, Mack B, et al. CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis. Stem Cells. 2013;31:1467-76 pubmed publisher
	O Boyle G, Swidenbank I, Marshall H, Barker C, Armstrong J, White S, et al. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. Br J Cancer. 2013;108:1634-40 pubmed publisher
	Zhang L, Ye S, Ma G, Tang X, Chen S, He J, et al. The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med. 2013;11:60 pubmed publisher
	Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev I, et al. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin Cancer Res. 2011;17:3619-30 pubmed publisher
	Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
	Pfeiffer M, Hartmann T, Leick M, Catusse J, Schmitt Graeff A, Burger M. Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer. Br J Cancer. 2009;100:1949-56 pubmed publisher
	Hansson M, Olesen D, Peterslund J, Engberg N, Kahn M, Winzi M, et al. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol. 2009;330:286-304 pubmed publisher
	Gilbert D, Chandler I, McIntyre A, Goddard N, Gabe R, Huddart R, et al. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents. J Pathol. 2009;217:94-102 pubmed publisher
	Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed publisher
	Tait L, Pauley R, Santner S, Heppner G, Heng H, Rak J, et al. Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int J Cancer. 2007;120:2127-34 pubmed
	Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, et al. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. Cardiovasc Res. 2006;71:455-65 pubmed
	Marchal Sommé J, Uzunhan Y, Marchand Adam S, Valeyre D, Soumelis V, Crestani B, et al. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol. 2006;176:5735-9 pubmed
	Scala S, Giuliano P, Ascierto P, Ierano C, Franco R, Napolitano M, et al. Human melanoma metastases express functional CXCR4. Clin Cancer Res. 2006;12:2427-33 pubmed
	Haringman J, Smeets T, Reinders Blankert P, Tak P. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis. 2006;65:294-300 pubmed
	Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, et al. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum. 2005;52:1504-16 pubmed
	Liao T, Yurgelun M, Chang S, Zhang H, Murakami K, Blaine T, et al. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J Orthop Res. 2005;23:203-9 pubmed
	Zhang Y, Foudi A, Geay J, Berthebaud M, Buet D, Jarrier P, et al. Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells. Stem Cells. 2004;22:1015-29 pubmed
	Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, et al. CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther. 2004;3:29-37 pubmed
	Cardones A, Murakami T, Hwang S. CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res. 2003;63:6751-7 pubmed
	Nguyen D, Taub D. CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol. 2002;168:4121-6 pubmed
	Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol. 2001;166:6477-82 pubmed

product information

brand :

R&D Systems

master code :

MAB172

SKU :

MAB172-100

product name :

Human CXCR4 Antibody

description :

The Human CXCR4 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR4. This antibody reacts with human. The Human CXCR4 Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Neutralization, CyTOF-ready.

target :

CXCR4

category :

Primary Antibodies

unit size :

100 ug (also 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

44716

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

3T3 cells transfected with human CXCR4

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human CXCR4. It will also react with cells expressing feline CXCR4 but not rat CXCR4.

gene symbol :

CXCR4

details of functionality :

ActivityAssaywCitation not found None None None

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB172

applications :

Flow Cytometry, Immunohistochemistry, Neutralization, CyTOF-ready

2020 USD :

339

2021 USD :

369 USD

alt names :

CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.