product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CXCR4 Antibody
catalog :
MAB172-100
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
44716
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 87
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig 4e, 4f
  • western blot; mouse; 1:100; loading ...; fig 4e, 4f
Choi Y, Kim Y, Oh S, Suh K, Kim Y, Lee G, et al. Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer. Adv Sci (Weinh). 2021;8:2002497 pubmed publisher
Das B, Kannan A, Velasco G, Kunika M, Lambrecht N, Nguyen Q, et al. Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities. Cell Rep Med. 2023;4:101101 pubmed publisher
Azcutia V, Kelm M, Kim S, Luissint A, Flemming S, Abernathy Close L, et al. Distinct stimulus-dependent neutrophil dynamics revealed by real-time imaging of intestinal mucosa after acute injury. PNAS Nexus. 2022;1:pgac249 pubmed publisher
D Alterio C, Giardino A, Scognamiglio G, Butturini G, Portella L, Guardascione G, et al. CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients. Cells. 2022;11: pubmed publisher
Tobiume M, Mitsuhashi A, Saijo A, Ogino H, Afroj T, Ogawa H, et al. Analysis of the chemotactic factors for tumor-infiltrating fibrocytes and their prognostic significances in lung cancer. Oncol Lett. 2022;24:417 pubmed publisher
D Alterio C, Spina A, Arenare L, Chiodini P, Napolitano M, Galdiero F, et al. Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients. Cancers (Basel). 2022;14: pubmed publisher
Jayakumar H, Seetharaman A, Sunder Singh S, Dhandapani H, Subramani J, Ganeshrajah S, et al. Combination of IDO1high and CCL19low expression in the tumor tissue reduces survival in HPV positive cervical cancer. J Reprod Immunol. 2022;149:103454 pubmed publisher
Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, et al. Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScience. 2021;24:103433 pubmed publisher
Armani Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube Ferrieu V, Benureau Y, et al. Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. PLoS Pathog. 2021;17:e1009526 pubmed publisher
Yarso K, Bellynda M, Azmiardi A, Wasita B, Heriyanto D, Astuti I, et al. Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients. Asian Pac J Cancer Prev. 2021;22:757-766 pubmed publisher
Gu xe9 rard A, Laurent V, Fromont G, Est xe8 ve D, Gilhodes J, Bonnelye E, et al. The Chemokine Receptor CCR3 Is Potentially Involved in the Homing of Prostate Cancer Cells to Bone: Implication of Bone-Marrow Adipocytes. Int J Mol Sci. 2021;22: pubmed publisher
Liu D, Steins A, Klaassen R, van der Zalm A, Bennink R, van Tienhoven G, et al. Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma. Biomedicines. 2020;8: pubmed publisher
McQuade A, Kang Y, Hasselmann J, Jairaman A, Sotelo A, Coburn M, et al. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2020;11:5370 pubmed publisher
Vallejo Armenta P, Santos Cuevas C, Soto Andonaegui J, Villanueva P xe9 rez R, Gonz xe1 lez D xed az J, Garc xed a P xe9 rez F, et al. 99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans. Contrast Media Mol Imaging. 2020;2020:2525037 pubmed publisher
Zheng J, Qu D, Wang C, Ding L, Zhou W. Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling. BMC Pregnancy Childbirth. 2020;20:87 pubmed publisher
Zhu Q, Luo R, Gu J, Hou Y, Chen Z, Xu F, et al. High CXCR4 Expression Predicts a Poor Prognosis in Resected Lung Adenosquamous Carcinoma. J Cancer. 2020;11:810-818 pubmed publisher
González I, Bauer P, Chapman W, Alipour Z, Rais R, Liu J, et al. Clinicopathologic determinants of pathologic treatment response in neoadjuvant treated rectal adenocarcinoma. Ann Diagn Pathol. 2020;45:151452 pubmed publisher
van Ipenburg J, de Waard N, Naus N, Jager M, Paridaens D, Verdijk R. Chemokine Receptor Expression Pattern Correlates to Progression of Conjunctival Melanocytic Lesions. Invest Ophthalmol Vis Sci. 2019;60:2950-2957 pubmed publisher
Giampieri R, Piva F, Occhipinti G, Bittoni A, Righetti A, Pagliaretta S, et al. Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy. PLoS ONE. 2019;14:e0215990 pubmed publisher
Runyan C, McIntosh S, Maestas M, Quinn K, Boren B, Ashley R. CXCR4 signaling at the ovine fetal-maternal interface regulates vascularization, CD34+ cell presence, and autophagy in the endometrium†. Biol Reprod. 2019;101:102-111 pubmed publisher
Del Molino Del Barrio I, Wilkins G, Meeson A, Ali S, Kirby J. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int J Mol Sci. 2018;19: pubmed publisher
Yoon J, Kim Y, Kwon S, Kim M, Kim Y, Kim J, et al. Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo. Theranostics. 2018;8:4620-4632 pubmed publisher
Sbrissa D, Semaan L, Govindarajan B, Li Y, Caruthers N, Stemmer P, et al. A novel cross-talk between CXCR4 and PI4KIIIα in prostate cancer cells. Oncogene. 2019;38:332-344 pubmed publisher
Chau M, Deveau T, Gu X, Kim Y, Xu Y, Yu S, et al. Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice. BMC Neurosci. 2018;19:20 pubmed publisher
Kitawaki Y, Nakamura Y, Kubota Nakayama F, Yamazaki Y, Miki Y, Hata S, et al. Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. Hum Pathol. 2018;77:88-97 pubmed publisher
Tang W, Chen Y, Wang X, Chen Y, Zhang J, Lin Z. Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. Oncol Lett. 2018;15:2501-2507 pubmed publisher
Zhang J, Liu C, Mo X, Shi H, Li S. Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer. Oncol Lett. 2018;15:1771-1776 pubmed publisher
Sánchez N, Quinn K, Ashley A, Ashley R. In the ovine pituitary, CXCR4 is localized in gonadotropes and somatotropes and increases with elevated serum progesterone. Domest Anim Endocrinol. 2018;62:88-97 pubmed publisher
Samarendra H, Jones K, Petrinic T, Silva M, Reddy S, Soonawalla Z, et al. A meta-analysis of CXCL12 expression for cancer prognosis. Br J Cancer. 2017;117:124-135 pubmed publisher
Kim Y, Choi Y, Lee J, Soh E, Kim J, Park T. Senescent tumor cells lead the collective invasion in thyroid cancer. Nat Commun. 2017;8:15208 pubmed publisher
Mercurio L, Cecchetti S, Ricci A, Pacella A, Cigliana G, Bozzuto G, et al. Phosphatidylcholine-specific phospholipase C inhibition down- regulates CXCR4 expression and interferes with proliferation, invasion and glycolysis in glioma cells. PLoS ONE. 2017;12:e0176108 pubmed publisher
Fareh M, Almairac F, Turchi L, Burel Vandenbos F, Paquis P, Fontaine D, et al. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth. Cell Death Dis. 2017;8:e2713 pubmed publisher
Hira V, Verbovšek U, Breznik B, Srdič M, Novinec M, Kakar H, et al. Cathepsin K cleavage of SDF-1? inhibits its chemotactic activity towards glioblastoma stem-like cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:594-603 pubmed publisher
Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, et al. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. J Virol. 2016;90:10642-10659 pubmed publisher
Wescott M, Kufareva I, Paes C, Goodman J, Thaker Y, Puffer B, et al. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016;113:9928-33 pubmed publisher
Geng Y, Feng B. A small molecule-based strategy for endothelial differentiation and three-dimensional morphogenesis from human embryonic stem cells. Heliyon. 2016;2:e00133 pubmed publisher
Mercurio L, Ajmone Cat M, Cecchetti S, Ricci A, Bozzuto G, Molinari A, et al. Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model. J Exp Clin Cancer Res. 2016;35:55 pubmed publisher
Kanninen L, Porola P, Niklander J, Malinen M, Corlu A, Guguen Guillouzo C, et al. Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix. Exp Cell Res. 2016;341:207-17 pubmed publisher
Coke C, Scarlett K, Chetram M, Jones K, Sandifer B, Davis A, et al. Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression. J Biol Chem. 2016;291:9991-10005 pubmed publisher
Laurent V, Guérard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, et al. Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nat Commun. 2016;7:10230 pubmed publisher
Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, et al. Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells. PLoS ONE. 2015;10:e0130808 pubmed publisher
Akazawa Y, Hasegawa T, Yoshimura Y, Chosa N, Asakawa T, Ueda K, et al. Recruitment of mesenchymal stem cells by stromal cell-derived factor 1α in pulp cells from deciduous teeth. Int J Mol Med. 2015;36:442-8 pubmed publisher
Cioffi M, D Alterio C, Camerlingo R, Tirino V, Consales C, Riccio A, et al. Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer. Sci Rep. 2015;5:10357 pubmed publisher
Gibson D, Greaves E, Critchley H, Saunders P. Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2. Hum Reprod. 2015;30:1290-301 pubmed publisher
Pilling D, Cox N, Vakil V, Verbeek J, Gomer R. The long pentraxin PTX3 promotes fibrocyte differentiation. PLoS ONE. 2015;10:e0119709 pubmed publisher
Neve Polimeno M, Ierano C, D Alterio C, Simona Losito N, Napolitano M, Portella L, et al. CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not. Cell Mol Immunol. 2015;12:474-82 pubmed publisher
Hu W, Liu Y, Zhou W, Si L, Ren L. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro. PLoS ONE. 2014;9:e99056 pubmed publisher
Hartmann N, Giese N, Giese T, Poschke I, Offringa R, Werner J, et al. Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer. Clin Cancer Res. 2014;20:3422-33 pubmed publisher
Jarajapu Y, Hazra S, Segal M, Li Calzi S, LiCalzi S, Jadhao C, et al. Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms. PLoS ONE. 2014;9:e93965 pubmed publisher
Zgraggen S, Huggenberger R, Kerl K, Detmar M. An important role of the SDF-1/CXCR4 axis in chronic skin inflammation. PLoS ONE. 2014;9:e93665 pubmed publisher
Yin X, Johns S, Kim D, Mikulski Z, SALANGA C, Handel T, et al. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014;192:2133-42 pubmed publisher
Hoque M, Windus L, Lovitt C, Avery V. PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture. PLoS ONE. 2013;8:e79865 pubmed publisher
Brennecke P, Arlt M, Muff R, Campanile C, Gvozdenović A, Husmann K, et al. Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice. PLoS ONE. 2013;8:e74045 pubmed publisher
Gassenmaier M, Chen D, Buchner A, Henkel L, Schiemann M, Mack B, et al. CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis. Stem Cells. 2013;31:1467-76 pubmed publisher
O Boyle G, Swidenbank I, Marshall H, Barker C, Armstrong J, White S, et al. Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070. Br J Cancer. 2013;108:1634-40 pubmed publisher
Zhang L, Ye S, Ma G, Tang X, Chen S, He J, et al. The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma. J Transl Med. 2013;11:60 pubmed publisher
Don Salu Hewage A, Chan S, McAndrews K, Chetram M, Dawson M, Bethea D, et al. Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoS ONE. 2013;8:e57194 pubmed publisher
Jin F, Ji H, Jia C, Brockmeier U, Hermann D, Metzen E, et al. Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. PLoS ONE. 2012;7:e47161 pubmed publisher
Wang L, Chen W, Gao L, Yang Q, Liu B, Wu Z, et al. High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma. World J Surg Oncol. 2012;10:212 pubmed publisher
Popple A, Durrant L, Spendlove I, Rolland P, Scott I, Deen S, et al. The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer. Br J Cancer. 2012;106:1306-13 pubmed publisher
Dubrovska A, Elliott J, Salamone R, Telegeev G, Stakhovsky A, Schepotin I, et al. CXCR4 expression in prostate cancer progenitor cells. PLoS ONE. 2012;7:e31226 pubmed publisher
Hernandez L, Magalhaes M, Coniglio S, Condeelis J, Segall J. Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res. 2011;13:R128 pubmed publisher
Dorfmuller P, Chaumais M, Giannakouli M, Durand Gasselin I, Raymond N, Fadel E, et al. Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. Respir Res. 2011;12:119 pubmed publisher
Smirnova T, Adomako A, Locker J, Van Rooijen N, Prystowsky M, Segall J. In vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages. Am J Pathol. 2011;178:2857-65 pubmed publisher
Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev I, et al. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin Cancer Res. 2011;17:3619-30 pubmed publisher
Rahimi M, Toth T, Tang C. CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells. Cancer Lett. 2011;306:43-51 pubmed publisher
Cronin P, Wang J, Redmond H. Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4. BMC Cancer. 2010;10:225 pubmed publisher
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr Relat Cancer. 2010;17:303-16 pubmed publisher
Rahimi M, George J, Tang C. EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. Int J Cancer. 2010;126:1850-1860 pubmed publisher
Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
Pfeiffer M, Hartmann T, Leick M, Catusse J, Schmitt Graeff A, Burger M. Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer. Br J Cancer. 2009;100:1949-56 pubmed publisher
Hong F, Tuyama A, Lee T, Loke J, Agarwal R, Cheng X, et al. Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. Hepatology. 2009;49:2055-67 pubmed publisher
Hansson M, Olesen D, Peterslund J, Engberg N, Kahn M, Winzi M, et al. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol. 2009;330:286-304 pubmed publisher
Gilbert D, Chandler I, McIntyre A, Goddard N, Gabe R, Huddart R, et al. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents. J Pathol. 2009;217:94-102 pubmed publisher
Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed publisher
Tait L, Pauley R, Santner S, Heppner G, Heng H, Rak J, et al. Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts. Int J Cancer. 2007;120:2127-34 pubmed
Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, et al. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. Cardiovasc Res. 2006;71:455-65 pubmed
Marchal Sommé J, Uzunhan Y, Marchand Adam S, Valeyre D, Soumelis V, Crestani B, et al. Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis. J Immunol. 2006;176:5735-9 pubmed
Scala S, Giuliano P, Ascierto P, Ierano C, Franco R, Napolitano M, et al. Human melanoma metastases express functional CXCR4. Clin Cancer Res. 2006;12:2427-33 pubmed
Haringman J, Smeets T, Reinders Blankert P, Tak P. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis. 2006;65:294-300 pubmed
Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, et al. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum. 2005;52:1504-16 pubmed
Liao T, Yurgelun M, Chang S, Zhang H, Murakami K, Blaine T, et al. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. J Orthop Res. 2005;23:203-9 pubmed
Zhang Y, Foudi A, Geay J, Berthebaud M, Buet D, Jarrier P, et al. Intracellular localization and constitutive endocytosis of CXCR4 in human CD34+ hematopoietic progenitor cells. Stem Cells. 2004;22:1015-29 pubmed
Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, et al. CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther. 2004;3:29-37 pubmed
Cardones A, Murakami T, Hwang S. CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res. 2003;63:6751-7 pubmed
Nguyen D, Taub D. CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol. 2002;168:4121-6 pubmed
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol. 2001;166:6477-82 pubmed
product information
brand :
R&D Systems
master code :
MAB172
SKU :
MAB172-100
product name :
Human CXCR4 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human CXCR4 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR4. This antibody reacts with human,mouse,rabbit,rat. The Human CXCR4 Antibody has been validated for the following applications: Binding Assay,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Functional Assay,ELISA Detection,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.
target :
CXCR4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
44716
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Neutralization 2.5-12 ug/mL, CyTOF-ready
host :
Mouse
immunogen :
3T3 cells transfected with human CXCR4
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rabbit,Rat
specificity :
Detects human CXCR4. It will also react with cells expressing feline CXCR4 but not rat CXCR4.
gene symbol :
CXCR4
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of CXCR4 antibody in Jurkat Human Cell Line antibody by Flow Cytometry.
applications :
CyTOF-ready,Binding Assay,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,Functional Assay,ELISA Detection
USD :
499 USD
alt names :
CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.