Human CXCR4 Antibody | R&D Systems MAB171-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR4 Antibody

catalog :

MAB171-100

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

44708

reactivity :

human

application :

western blot, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 23

Reference
Mause S, Ritzel E, Deck A, Vogt F, Liehn E. Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis. Int J Mol Sci. 2022;23: pubmed publisher
Armani Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube Ferrieu V, Benureau Y, et al. Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. PLoS Pathog. 2021;17:e1009526 pubmed publisher
Caccuri F, Bugatti A, Corbellini S, Roversi S, Zani A, Mazzuca P, et al. The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3). Int J Mol Sci. 2019;20: pubmed publisher
Lüke F, Blazquez R, Yamaci R, Lu X, Pregler B, Hannus S, et al. Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment. Oncotarget. 2018;9:18844-18857 pubmed publisher
Mushtaq M, Jensen L, Davidsson S, Grygoruk O, Andrén O, Kashuba V, et al. The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells. Sci Rep. 2018;8:2268 pubmed publisher
Schwarzenböck S, Stenzel J, Otto T, Helldorff H, Bergner C, Kurth J, et al. [68Ga]pentixafor for CXCR4 imaging in a PC-3 prostate cancer xenograft model - comparison with [18F]FDG PET/CT, MRI and ex vivo receptor expression. Oncotarget. 2017;8:95606-95619 pubmed publisher
Wescott M, Kufareva I, Paes C, Goodman J, Thaker Y, Puffer B, et al. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016;113:9928-33 pubmed publisher
Zhu D, Wang Z, Zhao J, Calimeri T, Meng J, Hideshima T, et al. The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. Nat Med. 2015;21:572-80 pubmed publisher
DiCosmo Ponticello C, Hoover D, Coffman F, Cohen S, Cohen M. MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells. Cytokine. 2014;69:47-55 pubmed publisher
Calpe E, Purroy N, Carpio C, Abrisqueta P, Carabia J, Palacio C, et al. ZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation. PLoS ONE. 2013;8:e81221 pubmed publisher
Shi P, Binnington B, Sakac D, Katsman Y, Ramkumar S, Gariepy J, et al. Verotoxin A subunit protects lymphocytes and T cell lines against X4 HIV infection in vitro. Toxins (Basel). 2012;4:1517-34 pubmed publisher
Wei F, Moore D, Wei L, Li Y, Zhang G, Wei X, et al. Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway. Arthritis Res Ther. 2012;14:R177 pubmed publisher
Guo L, Cui Z, Zhang J, Huang Y. Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma. Chin J Cancer. 2011;30:336-43 pubmed
Rubie C, Frick V, Ghadjar P, Wagner M, Justinger C, Faust S, et al. CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells. J Transl Med. 2011;9:22 pubmed publisher
Weiss N, Deboux C, Chaverot N, Miller F, Baron van Evercooren A, Couraud P, et al. IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells. J Neuroimmunol. 2010;223:131-4 pubmed publisher
Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, et al. Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation. Dev Biol. 2010;341:236-45 pubmed publisher
Simons D, Grieb G, Hristov M, Pallua N, Weber C, Bernhagen J, et al. Hypoxia-induced endothelial secretion of macrophage migration inhibitory factor and role in endothelial progenitor cell recruitment. J Cell Mol Med. 2011;15:668-78 pubmed publisher
Ouwehand K, Santegoets S, Bruynzeel D, Scheper R, de Gruijl T, Gibbs S. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur J Immunol. 2008;38:3050-9 pubmed publisher
Ao M, Franco O, Park D, Raman D, Williams K, Hayward S. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res. 2007;67:4244-53 pubmed
Singh S, Singh U, Grizzle W, Lillard J. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest. 2004;84:1666-76 pubmed
Wald O, Pappo O, Safadi R, Dagan Berger M, Beider K, Wald H, et al. Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur J Immunol. 2004;34:1164-74 pubmed
Hatse S, Princen K, Vermeire K, Gerlach L, Rosenkilde M, Schwartz T, et al. Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. FEBS Lett. 2003;546:300-6 pubmed
Nguyen D, Taub D. CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol. 2002;168:4121-6 pubmed

product information

master code :

MAB171

SKU :

MAB171-100

product name :

Human CXCR4 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human CXCR4 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR4. This antibody reacts with human,xenograft. The Human CXCR4 Antibody has been validated for the following applications: Immunohistochemistry,Binding Assay,FCCS,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

CXCR4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

44708

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

3T3 cells transfected with human CXCR4

isotype :

IgG2a

purity :

Protein A or G purified from ascites

species :

Human,Xenograft

specificity :

Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.

gene symbol :

CXCR4

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Chemotaxis Induced by CXCL12/SDF-1a and Neutralization by Human CXCR4 Antibody.

applications :

Binding Assay,FCCS,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

479 USD

alt names :

CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage