product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse Siglec-F Antibody
catalog :
MAB17061-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
238047
reactivity :
human, mouse
application :
neutralization
more info or order :
R&D Systems product webpage
citations: 9
Reference
Willems M, Hamaidia M, Fontaine A, Gr xe9 goire M, Halkin L, Vilanova Ma xf1 xe1 L, et al. The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity. EBioMedicine. 2024;109:105418 pubmed publisher
Li C, Ward L, Nguyen A, Lam E, Dasoveanu D, Ahmed M, et al. Neonatal LTβR signaling is required for the accumulation of eosinophils in the inflamed adult mesenteric lymph node. Mucosal Immunol. 2022;15:418-427 pubmed publisher
Chetty A, Darby M, Vornewald P, Martín Alonso M, Filz A, Ritter M, et al. Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host Microbe. 2021;29:579-593.e5 pubmed publisher
Cheng J, Luo W, Sun C, Jin Z, Zeng X, Alexander P, et al. Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy. Sci Adv. 2021;7: pubmed publisher
Shani O, Vorobyov T, Monteran L, Lavie D, Cohen N, Raz Y, et al. Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity. Cancer Res. 2020;80:5317-5329 pubmed publisher
Jia S, Li W, Liu P, Xu L. A role of eosinophils in mediating the anti-tumour effect of cryo-thermal treatment. Sci Rep. 2019;9:13214 pubmed publisher
Noor Z, Watanabe K, Abhyankar M, Burgess S, Buonomo E, Cowardin C, et al. Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin-25-Mediated Protection from Amebic Colitis. MBio. 2017;8: pubmed publisher
Besnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw T, et al. IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathog. 2015;11:e1004607 pubmed publisher
Chu V, Beller A, Rausch S, Strandmark J, Zänker M, Arbach O, et al. Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis. Immunity. 2014;40:582-93 pubmed publisher
product information
master code :
MAB17061
SKU :
MAB17061-100
product name :
Mouse Siglec-F Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Mouse Siglec-F Antibody from R&D Systems is a rat monoclonal antibody to Siglec-F. This antibody reacts with mouse. The Mouse Siglec-F Antibody has been validated for the following applications: In vivo assay,Neutralization,Bioassay.
target :
Siglec-F
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
238047
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Siglec-F, Asp18-Thr437, Accession # Q920G3
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse
specificity :
Detects mouse Siglec-F in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse Siglec-2 or -3, or recombinant human Siglec-5, -7, -9, -10, or -11 is observed.
gene symbol :
Siglecf
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Adhesion Mediated by Siglec-F and Neutralization by Mouse Siglec-F Antibody.
accessionNumbers :
Q920G3
applications :
In vivo assay,Neutralization,Bioassay
USD :
479 USD
alt names :
SAF2, sialic acid binding Ig like lectin 8, SIGLEC-8, SIGLEC8L, SiglecF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.