Human CXCR4 Antibody | R&D Systems MAB170 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR4 Antibody

catalog :

MAB170

quantity :

500 ug (also 25 ug)

price :

559 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12G5

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 42

Reference
Lesniak W, Azad B, Chatterjee S, Lisok A, Pomper M. An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications. Pharmaceutics. 2022;14: pubmed publisher
Cantini G, Fei L, Canu L, Lazzeri E, Sottili M, Francalanci M, et al. Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression. J Pers Med. 2021;11: pubmed publisher
Armani Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube Ferrieu V, Benureau Y, et al. Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. PLoS Pathog. 2021;17:e1009526 pubmed publisher
Ierano C, D Alterio C, Giarra S, Napolitano M, Rea G, Portella L, et al. CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells. Cell Death Dis. 2019;10:562 pubmed publisher
Li S, Fong K, Gritsina G, Zhang A, Zhao J, Kim J, et al. Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer. Cancer Res. 2019;79:2580-2592 pubmed publisher
Dinkel B, Kremer K, Rollins M, Medlyn M, Hedin K. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion. J Biol Chem. 2018;293:14022-14039 pubmed publisher
Mills S, Howell L, Beekman A, Stokes L, Mueller A. Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4. Cell Signal. 2018;42:88-96 pubmed publisher
Minami H, Nagaharu K, Nakamori Y, Ohishi K, Shimojo N, Kageyama Y, et al. CXCL12-CXCR4 Axis Is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but Not T Lymphoid Generation. J Immunol. 2017;199:2343-2355 pubmed publisher
Wu W, Grotefend C, Tsai M, Wang Y, Radic V, Eoh H, et al. ?20 IFITM2 differentially restricts X4 and R5 HIV-1. Proc Natl Acad Sci U S A. 2017;114:7112-7117 pubmed publisher
Han Y, Wu C, Wang J, Liu N. CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment. Tumour Biol. 2017;39:1010428317701631 pubmed publisher
Wescott M, Kufareva I, Paes C, Goodman J, Thaker Y, Puffer B, et al. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016;113:9928-33 pubmed publisher
Lopez Haber C, Barrio Real L, Casado Medrano V, Kazanietz M. Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α. Mol Cell Biol. 2016;36:2011-26 pubmed publisher
Griffiths K, Dolezal O, Cao B, Nilsson S, See H, Pfleger K, et al. i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. J Biol Chem. 2016;291:12641-57 pubmed publisher
Patrussi L, Capitani N, Martini V, Pizzi M, Trimarco V, Frezzato F, et al. Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia. Cancer Res. 2015;75:4153-63 pubmed publisher
Shankar V, Hori H, Kihira K, Lei Q, Toyoda H, Iwamoto S, et al. Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines. PLoS ONE. 2015;10:e0120069 pubmed publisher
Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, et al. The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clin Cancer Res. 2015;21:2840-50 pubmed publisher
Lin Y, Yet S, Hsu Y, Wang G, Hung S. Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function. Stem Cells Transl Med. 2015;4:44-55 pubmed publisher
Coggins N, Trakimas D, Chang S, Ehrlich A, Ray P, Luker K, et al. CXCR7 controls competition for recruitment of ?-arrestin 2 in cells expressing both CXCR4 and CXCR7. PLoS ONE. 2014;9:e98328 pubmed publisher
Choi Y, Burdick M, Strieter B, Mehrad B, Strieter R. CXCR4, but not CXCR7, discriminates metastatic behavior in non-small cell lung cancer cells. Mol Cancer Res. 2014;12:38-47 pubmed publisher
Park B, Kook S, Lee S, Jeong J, Brufsky A, Lee B. An isoform of C/EBP?, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. J Biol Chem. 2013;288:28656-67 pubmed publisher
Singareddy R, Semaan L, Conley LaComb M, St John J, Powell K, Iyer M, et al. Transcriptional regulation of CXCR4 in prostate cancer: significance of TMPRSS2-ERG fusions. Mol Cancer Res. 2013;11:1349-61 pubmed publisher
de Poorter C, Baertsoen K, Lannoy V, Parmentier M, Springael J. Consequences of ChemR23 heteromerization with the chemokine receptors CXCR4 and CCR7. PLoS ONE. 2013;8:e58075 pubmed publisher
Lippert D, Wilkins J. Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes. BMC Immunol. 2012;13:21 pubmed
Baek S, Kang S, Ra J. In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors. Exp Mol Med. 2011;43:596-603 pubmed publisher
Fareh M, Turchi L, Virolle V, Debruyne D, Almairac F, de la Forest Divonne S, et al. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ. 2012;19:232-44 pubmed publisher
Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev I, et al. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin Cancer Res. 2011;17:3619-30 pubmed publisher
Rahimi M, George J, Tang C. EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. Int J Cancer. 2010;126:1850-1860 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB170

SKU :

MAB170

product name :

Human CXCR4 Antibody

unit size :

500 ug (also 25 ug)

seo description :

The Human CXCR4 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR4. This antibody reacts with human,mouse. The Human CXCR4 Antibody has been validated for the following applications: Flow Cytometry,Bioassay,Binding Assay,Neutralization Control,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-reported.

target :

CXCR4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

12G5

conjugate :

Unconjugated

dilution :

Flow Cytometry 0.25 ug/10^6 cells, Neutralization 0.3-1.2 ug/mL, CyTOF-reported

host :

Mouse

immunogen :

CP-MAC-infected SUP-T1 human T cell lymphoblastic lymphoma line, Accession # P61073

isotype :

IgG2a

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human CXCR4.

gene symbol :

CXCR4

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of CXCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.

accessionNumbers :

P61073

applications :

CyTOF-reported,Bioassay,Binding Assay,Neutralization Control,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry

USD :

559 USD

alt names :

CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage