Human HMGB1/HMG-1 Antibody | R&D Systems MAB1690 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human HMGB1/HMG-1 Antibody

catalog :

MAB1690

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

115603

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation, immunohistochemistry - frozen section

citations: 20

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; human; loading ...; fig 4	Ujiie I, Fujita Y, Nakayama C, Matsumura W, Suzuki S, Shinkuma S, et al. Altered balance of epidermis-related chemokines in epidermolysis bullosa. J Dermatol Sci. 2017;86:37-45 pubmed publisher
	Begum S, Moreau F, Leon Coria A, Chadee K. Entamoeba histolytica stimulates the alarmin molecule HMGB1 from macrophages to amplify innate host defenses. Mucosal Immunol. 2020;13:344-356 pubmed publisher
	Corneth O, Schaper F, Luk F, Asmawidjaja P, Mus A, Horst G, et al. Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice. Sci Rep. 2019;9:4032 pubmed publisher
	Haruma J, Teshigawara K, Hishikawa T, Wang D, Liu K, Wake H, et al. Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats. Sci Rep. 2016;6:37755 pubmed publisher
	Moser B, Megerle A, Bekos C, Janik S, Szerafin T, Birner P, et al. Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH. PLoS ONE. 2014;9:e106440 pubmed publisher
	Moser B, Janik S, Schiefer A, Müllauer L, Bekos C, Scharrer A, et al. Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. PLoS ONE. 2014;9:e94118 pubmed publisher
	Zhou H, Ji X, Wu Y, Xuan J, Qi Z, Shen L, et al. A dual-role of Gu-4 in suppressing HMGB1 secretion and blocking HMGB1 pro-inflammatory activity during inflammation. PLoS ONE. 2014;9:e89634 pubmed publisher
	Suwara M, Green N, Borthwick L, Mann J, Mayer Barber K, Barron L, et al. IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol. 2014;7:684-93 pubmed publisher
	Liou T, Adler F, Keogh R, Li Y, Jensen J, Walsh W, et al. Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. PLoS ONE. 2012;7:e42748 pubmed publisher
	Sperling T, Ołdak M, Walch Rückheim B, Wickenhauser C, Doorbar J, Pfister H, et al. Human papillomavirus type 8 interferes with a novel C/EBP?-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration. PLoS Pathog. 2012;8:e1002833 pubmed publisher
	Colombo B, Canevali P, Magnani O, Rossi E, Puppo F, Zocchi M, et al. Defective expression and function of the leukocyte associated Ig-like receptor 1 in B lymphocytes from systemic lupus erythematosus patients. PLoS ONE. 2012;7:e31903 pubmed publisher
	Donnelly O, Errington Mais F, Steele L, Hadac E, Jennings V, Scott K, et al. Measles virus causes immunogenic cell death in human melanoma. Gene Ther. 2013;20:7-15 pubmed publisher
	Vitali R, Stronati L, Negroni A, Di Nardo G, Pierdomenico M, Del Giudice E, et al. Fecal HMGB1 is a novel marker of intestinal mucosal inflammation in pediatric inflammatory bowel disease. Am J Gastroenterol. 2011;106:2029-40 pubmed publisher
	Zhou J, Huang J, Poon V, Chen D, Chan C, Ng F, et al. Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. J Hepatol. 2009;51:322-32 pubmed publisher
	DAVE S, Tilstra J, Matsuoka K, Li F, DeMarco R, Beer Stolz D, et al. Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J Leukoc Biol. 2009;86:633-43 pubmed publisher
	Rowe S, Jackson P, Liu G, Hardison M, Livraghi A, Solomon G, et al. Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med. 2008;178:822-31 pubmed publisher
	Aychek T, Miller K, Sagi Assif O, Levy Nissenbaum O, Israeli Amit M, Pasmanik Chor M, et al. E-selectin regulates gene expression in metastatic colorectal carcinoma cells and enhances HMGB1 release. Int J Cancer. 2008;123:1741-50 pubmed publisher
	Rao D, Tracey K, Pober J. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J Immunol. 2007;179:6536-46 pubmed
	Seki E, De Minicis S, Osterreicher C, Kluwe J, Osawa Y, Brenner D, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13:1324-32 pubmed
	Zetterström C, Jiang W, Wähämaa H, Ostberg T, Aveberger A, Schierbeck H, et al. Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. J Leukoc Biol. 2008;83:31-8 pubmed

product information

brand :

R&D Systems

master code :

MAB1690

SKU :

MAB1690-100

product name :

Human HMGB1/HMG-1 Antibody

description :

The Human HMGB1/HMG-1 Antibody from R&D Systems is a mouse monoclonal antibody to HMGB1/HMG-1. This antibody reacts with human. The Human HMGB1/HMG-1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Intracellular Staining by Flow Cytometry, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry, CyTOF-ready.

target :

HMGB1/HMG-1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

115603

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human HMGB1/HMG-1, Gly2-Glu215 (predicted), Accession # P09429

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human HMGB1/HMG-1 in direct ELISAs and Western blots.

gene symbol :

HMGB1

details of functionality :

ActivityAssaywCitation not found None None None None None

catalog number base :

MAB1690

accessionNumbers :

P09429

applications :

Western Blot, Immunohistochemistry, Intracellular Staining by Flow Cytometry, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry, CyTOF-ready

2020 USD :

339

2021 USD :

369 USD

alt names :

Amphoterin, high mobility group box 1, High mobility group protein 1, high mobility group protein B1, high-mobility group (nonhistone chromosomal) protein 1, high-mobility group box 1, HMG1, HMG-1, HMG1DKFZp686A04236, HMG3, SBP-1, Sulfoglucuronyl carbohydrate binding protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.