product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse IL-23R Antibody
catalog :
MAB1686-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
258010
reactivity :
human, mouse
application :
western blot, neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 12
Reference
Han S, Kim B, Hyeon D, Jeong D, Ryu J, Nam J, et al. Distinctive CD39+CD9+ lung interstitial macrophages suppress IL-23/Th17-mediated neutrophilic asthma by inhibiting NETosis. Nat Commun. 2024;15:8628 pubmed publisher
Chen Y, Shao C, Fan N, Nakao T, Amouzegar A, Chauhan S, et al. The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease. Mucosal Immunol. 2021;14:177-186 pubmed publisher
Zarin P, In T, Chen E, Singh J, Wong G, Mohtashami M, et al. Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation. Immunol Cell Biol. 2018;96:994-1007 pubmed publisher
Hummel T, Ackfeld T, Schönberg M, Ciupka G, Schulz F, Oberdoerster A, et al. Synthetic Deletion of the Interleukin 23 Receptor (IL-23R) Stalk Region Led to Autonomous IL-23R Homodimerization and Activation. Mol Cell Biol. 2017;37: pubmed publisher
Nasti T, Cochran J, Vachhani R, McKay K, Tsuruta Y, Athar M, et al. IL-23 Inhibits Melanoma Development by Augmenting DNA Repair and Modulating T Cell Subpopulations. J Immunol. 2017;198:950-961 pubmed publisher
Murphy A, O Keeffe K, Lalor S, Maher B, Mills K, McLoughlin R. Staphylococcus aureus infection of mice expands a population of memory ?? T cells that are protective against subsequent infection. J Immunol. 2014;192:3697-708 pubmed publisher
He J, Lang G, Ding S, Li L. Pathological role of interleukin-17 in poly I:C-induced hepatitis. PLoS ONE. 2013;8:e73909 pubmed publisher
Kumar P, Thakar M, Ouyang W, Malarkannan S. IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection. Mucosal Immunol. 2013;6:69-82 pubmed publisher
Ma Y, Aymeric L, Locher C, Mattarollo S, Delahaye N, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med. 2011;208:491-503 pubmed publisher
Wu S, Rhee K, Albesiano E, RABIZADEH S, Wu X, Yen H, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009;15:1016-22 pubmed publisher
Harris T, Grosso J, Yen H, Xin H, Kortylewski M, Albesiano E, et al. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179:4313-7 pubmed
Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol. 2007;178:4466-72 pubmed
product information
master code :
MAB1686
SKU :
MAB1686-100
product name :
Mouse IL-23R Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Mouse IL-23R Antibody from R&D Systems is a rat monoclonal antibody to IL-23R. This antibody reacts with mouse. The Mouse IL-23R Antibody has been validated for the following applications: Bioassay,in vivo blocking,Flow Cytometry,Neutralization,Western Blot.
target :
IL-23R
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
258010
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse IL-23 R, Gly24-Asp372, Accession # Q8K4B4
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse
specificity :
Detects mouse IL-23 R in Western blots. In Western blots, this antibody does not cross-react with recombinant human IL-23 R.
gene symbol :
IL23R
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
IL-17 Secretion Induced by IL-23 and Neutralization by Mouse IL-23 R Antibody.
accessionNumbers :
Q8K4B4
applications :
Bioassay,in vivo blocking,Flow Cytometry,Neutralization,Western Blot
USD :
469 USD
alt names :
IBD17, IL-23 R, IL-23 receptor, IL23R, IL-23R, interleukin 23 receptor, interleukin-23 receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.