Human CFTR R Domain Antibody | R&D Systems MAB1660 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CFTR R Domain Antibody

catalog :

MAB1660

quantity :

50 ug (also 25 ug)

price :

379 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13-1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 17

Reference
Liu Z, Anderson J, Natt J, Guimbellot J. Culture and Imaging of Human Nasal Epithelial Organoids. J Vis Exp. 2021;: pubmed publisher
Liu Z, Anderson J, Deng L, Mackay S, Bailey J, Kersh L, et al. Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis. Genes (Basel). 2020;11: pubmed publisher
Poroca D, Amer N, Li A, Hanrahan J, Chappe V. Changes in the R-region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel. FASEB Bioadv. 2020;2:33-48 pubmed publisher
Xia E, Zhang Y, Cao H, Li J, Duan R, Hu J. TALEN-Mediated Gene Targeting for Cystic Fibrosis-Gene Therapy. Genes (Basel). 2019;10: pubmed publisher
Xia E, Duan R, Shi F, Seigel K, Grasemann H, Hu J. Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction. Mol Ther Nucleic Acids. 2018;13:699-709 pubmed publisher
Bozoky Z, Ahmadi S, Milman T, Kim T, Du K, Di Paola M, et al. Synergy of cAMP and calcium signaling pathways in CFTR regulation. Proc Natl Acad Sci U S A. 2017;114:E2086-E2095 pubmed publisher
Zinn V, Khatri A, Mednieks M, Hand A. Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells. Eur J Oral Sci. 2015;123:140-8 pubmed publisher
Dong Q, Ernst S, Ostedgaard L, Shah V, Ver Heul A, Welsh M, et al. Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in . J Biol Chem. 2015;290:14140-53 pubmed publisher
Marcorelles P, Friocourt G, Uguen A, Ledé F, Ferec C, Laquerriere A. Cystic fibrosis transmembrane conductance regulator protein (CFTR) expression in the developing human brain: comparative immunohistochemical study between patients with normal and mutated CFTR. J Histochem Cytochem. 2014;62:791-801 pubmed publisher
Yan Z, Keiser N, Song Y, Deng X, Cheng F, Qiu J, et al. A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia. Mol Ther. 2013;21:2181-94 pubmed publisher
Sorio C, Buffelli M, Angiari C, Ettorre M, Johansson J, Vezzalini M, et al. Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis. PLoS ONE. 2011;6:e22212 pubmed publisher
Wong A, Keating A, Lu W, Duchesneau P, Wang X, Sacher A, et al. Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium. J Clin Invest. 2009;119:336-48 pubmed publisher
Davidson H, McLachlan G, Wilson A, Boyd A, Doherty A, MacGregor G, et al. Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways. Am J Respir Cell Mol Biol. 2006;35:72-83 pubmed
Basavappa S, Vulapalli S, Zhang H, Yule D, Coon S, Sundaram U. Chloride channels in the small intestinal cell line IEC-18. J Cell Physiol. 2005;202:21-31 pubmed
Koehler D, Sajjan U, Chow Y, Martin B, Kent G, Tanswell A, et al. Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia. Proc Natl Acad Sci U S A. 2003;100:15364-9 pubmed
Willumsen N, Amstrup J, Møbjerg N, Jespersen A, Kristensen P, Larsen E. Mitochondria-rich cells as experimental model in studies of epithelial chloride channels. Biochim Biophys Acta. 2002;1566:28-43 pubmed
Bagorda A, Guerra L, Di Sole F, Hemle Kolb C, Cardone R, Fanelli T, et al. Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model. J Biol Chem. 2002;277:21480-8 pubmed

product information

brand :

R&D Systems

master code :

MAB1660

SKU :

MAB1660

product name :

Human CFTR R Domain Antibody

unit size :

50 ug (also 25 ug)

seo description :

The Human CFTR R Domain Antibody from R&D Systems is a mouse monoclonal antibody to CFTR. This antibody reacts with amphibian,human,mouse,ovine,rat,frog - xenopus (african clawed frog). The Human CFTR R Domain Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunofluorescence.

target :

CFTR

category :

Primary Antibodies

buffer :

Supplied as a solution in PBS containing BSA. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

13-1

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Immunohistochemistry 8-25 ug/mL, Immunoprecipitation 1-2 ug/10^6 cells, Immunofluorescence

host :

Mouse

immunogen :

▀-galactosidase-coupled CFTR, Cys590-Lys830 (predicted), Accession # P13569

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Amphibian,Human,Mouse,Ovine,Rat,Frog - Xenopus (African Clawed Frog)

specificity :

Detects human CFTR. Specifically recognizes in vitro synthesized CFTR, recombinant CFTR protein, and non-recombinant CFTR protein (1, 2).

gene symbol :

CFTR

top caption :

CFTR antibody in Human Placenta by Immunohistochemistry (IHC-P).

accessionNumbers :

P13569

applications :

Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

379 USD

alt names :

ABC35, ABCC7CF, ATP-binding cassette sub-family C member 7, ATP-binding cassette transporter sub-family C member 7, cAMP-dependent chloride channel, CFTR/MRP, Channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulator, cystic fibrosis transmembrane conductance regulator (ATP-binding cassettesub-family C, member 7), cystic fibrosis transmembrane conductance regulator, ATP-binding cassette(sub-family C, member 7), dJ760C5.1, EC 3.6.3, MRP7EC 3.6.3.49, TNR-CFTR

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C, as supplied. 1 month, 2 to 8 ░C under sterile conditions after opening. 6 months, -20 to -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage