Human DC-SIGN+DC-SIGNR Antibody | R&D Systems MAB1621-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human DC-SIGN+DC-SIGNR Antibody

catalog :

MAB1621-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

120612

reactivity :

human, rhesus macaque

application :

immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 17

Reference
Messingham K, Richards P, Fleck A, Patel R, Djurkovic M, Elliff J, et al. Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin. Sci Adv. 2025;11:eadr6140 pubmed publisher
Rader A, Cloherty A, Patel K, Almandawi D, Pajkrt D, Wolthers K, et al. HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa. PLoS Pathog. 2024;20:e1012714 pubmed publisher
Diop M, Molina O, Birlea M, LaRue H, Hovington H, T xea tu B, et al. Leukocytic Infiltration of Intraductal Carcinoma of the Prostate: An Exploratory Study. Cancers (Basel). 2023;15: pubmed publisher
Mercnik M, Schliefsteiner C, Fluhr H, Wadsack C. Placental macrophages present distinct polarization pattern and effector functions depending on clinical onset of preeclampsia. Front Immunol. 2022;13:1095879 pubmed publisher
Puray Chavez M, Lapak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep. 2021;36:109364 pubmed publisher
Morcom L, Gobius I, Marsh A, Suárez R, Lim J, Bridges C, et al. DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. elife. 2021;10: pubmed publisher
Dunk C, Kwan M, Hazan A, Walker S, Wright J, Harris L, et al. Failure of Decidualization and Maternal Immune Tolerance Underlies Uterovascular Resistance in Intra Uterine Growth Restriction. Front Endocrinol (Lausanne). 2019;10:160 pubmed publisher
Aagaard K, Lahon A, Suter M, Arya R, Seferovic M, Vogt M, et al. Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication. Sci Rep. 2017;7:41389 pubmed publisher
Mazelier M, Rouxel R, Zumstein M, Mancini R, Bell Sakyi L, Lozach P. Uukuniemi Virus as a Tick-Borne Virus Model. J Virol. 2016;90:6784-98 pubmed publisher
Tani H, Shimojima M, Fukushi S, Yoshikawa T, Fukuma A, Taniguchi S, et al. Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus. J Virol. 2016;90:5292-5301 pubmed publisher
Sotiriou G, Hirt A, Lozach P, Teleki A, Krumeich F, Pratsinis S. Hybrid, silica-coated, Janus-like plasmonic-magnetic nanoparticles. Chem Mater. 2011;23:1985-1992 pubmed
Chen Y, Hwang S, Chan V, Chung N, Wang S, Li Z, et al. Binding of HIV-1 gp120 to DC-SIGN promotes ASK-1-dependent activation-induced apoptosis of human dendritic cells. PLoS Pathog. 2013;9:e1003100 pubmed publisher
Mansfield K, Lang S, Gauduin M, Sanford H, Lifson J, Johnson R, et al. Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery. J Virol. 2008;82:4135-48 pubmed publisher
Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, et al. CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes. AIDS Res Hum Retroviruses. 2006;22:1152-61 pubmed
Falkowska E, Durso R, Gardner J, Cormier E, Arrigale R, Ogawa R, et al. L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles. J Gen Virol. 2006;87:2571-6 pubmed
Yearley J, Pearson C, Carville A, Shannon R, Mansfield K. SIV-associated myocarditis: viral and cellular correlates of inflammation severity. AIDS Res Hum Retroviruses. 2006;22:529-40 pubmed
Wu L, Bashirova A, Martin T, Villamide L, Mehlhop E, Chertov A, et al. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Proc Natl Acad Sci U S A. 2002;99:1568-73 pubmed

product information

master code :

MAB1621

SKU :

MAB1621-100

product name :

Human DC-SIGN+DC-SIGNR Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human DC-SIGN+DC-SIGNR Antibody from R&D Systems is a mouse monoclonal antibody to DC-SIGN+DC-SIGNR. This antibody reacts with human,primate - macaca mulatta (rhesus macaque). The Human DC-SIGN+DC-SIGNR Antibody has been validated for the following applications: Flow Cytometry,Immunohistochemistry,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready.

target :

DC-SIGN+DC-SIGNR

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

120612

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NIH-3T3 mouse embryonic fibroblast cell line transfected with human DC-SIGNR, Accession # Q9H2X3

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Primate - Macaca mulatta (Rhesus Macaque)

specificity :

Recognizes both human DC-SIGN and human DC-SIGNR on transfected cells. Does not react with parental mouse cells or irrelevant transfectants.

gene symbol :

CD209

top caption :

Detection of DC-SIGN+DC-SIGNR antibody in Human DC-SIGN or DC-SIGNR Transfected 3T3 Mouse Cell Line antibody by Flow Cytometry.

accessionNumbers :

Q9H2X3

applications :

Flow Cytometry,Neutralization,Functional Assay,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready

USD :

469 USD

alt names :

CD209, CD209;CD209 antigen;CDSIGN;CLEC4L;DC-SIGN;DC-SIGN1;hDC-SIGN, CD209L, CD299, CLEC4L, CLEC4M, DCSIGN, DCSIGN+DCSIGNR, DC-SIGN1, DC-SIGN2, DCSIGNR, LSIGN

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage