Human DC-SIGNR/CD299 Antibody | R&D Systems MAB162 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human DC-SIGNR/CD299 Antibody

catalog :

MAB162

quantity :

500 ug (also 25 ug)

price :

559 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

120604

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 18

Reference
Shimojima M, Sugimoto S, Taniguchi S, Maeki T, Yoshikawa T, Kurosu T, et al. N-glycosylation of viral glycoprotein is a novel determinant for the tropism and virulence of highly pathogenic tick-borne bunyaviruses. PLoS Pathog. 2024;20:e1012348 pubmed publisher
Guo L, Liang Y, Li H, Zheng H, Yang Z, Chen Y, et al. Epigenetic glycosylation of SARS-CoV-2 impact viral infection through DC&L-SIGN receptors. iScience. 2021;24:103426 pubmed publisher
Wessel A, Doyle M, Engdahl T, Rodriguez J, Crowe J, Diamond M. Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection. MBio. 2021;12:e0244021 pubmed publisher
Kondo Y, Larabee J, Gao L, Shi H, Shao B, Hoover C, et al. L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus. JCI Insight. 2021;6: pubmed publisher
Xiang M, Grosso R, Takeda A, Pan J, Bekkhus T, Brulois K, et al. A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature. Front Cardiovasc Med. 2020;7:52 pubmed publisher
Vogt M, Lahon A, Arya R, Spencer Clinton J, Rico Hesse R. Dengue viruses infect human megakaryocytes, with probable clinical consequences. PLoS Negl Trop Dis. 2019;13:e0007837 pubmed publisher
Carbaugh D, Baric R, Lazear H. Envelope Protein Glycosylation Mediates Zika Virus Pathogenesis. J Virol. 2019;93: pubmed publisher
Goo L, Debbink K, Kose N, Sapparapu G, Doyle M, Wessel A, et al. A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions. Nat Microbiol. 2019;4:71-77 pubmed publisher
Swystun L, Lai J, Notley C, Georgescu I, Paine A, Mewburn J, et al. The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity. J Clin Invest. 2018;128:4057-4073 pubmed publisher
Ishibashi M, Morita N, Nomura Kawaguchi C, Shimizu Y, Wakita T, Esumi M. CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection. Arch Virol. 2014;159:2949-55 pubmed publisher
Johnson T, McLellan J, Graham B. Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2. J Virol. 2012;86:1339-47 pubmed publisher
Crosby H, Lalor P, Ross E, Newsome P, Adams D. Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J Hepatol. 2009;51:734-49 pubmed publisher
Jain P, Manuel S, Khan Z, Ahuja J, Quann K, Wigdahl B. DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J Virol. 2009;83:10908-21 pubmed publisher
Chaipan C, Soilleux E, Simpson P, Hofmann H, Gramberg T, Marzi A, et al. DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol. 2006;80:8951-60 pubmed
Falkowska E, Durso R, Gardner J, Cormier E, Arrigale R, Ogawa R, et al. L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles. J Gen Virol. 2006;87:2571-6 pubmed
Karrar A, Broome U, Uzunel M, Qureshi A, Sumitran Holgersson S. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut. 2007;56:243-52 pubmed
Lai W, Sun P, Zhang J, Jennings A, Lalor P, Hubscher S, et al. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am J Pathol. 2006;169:200-8 pubmed
Ludwig I, Lekkerkerker A, Depla E, Bosman F, Musters R, Depraetere S, et al. Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation. J Virol. 2004;78:8322-32 pubmed

product information

brand :

R&D Systems

master code :

MAB162

SKU :

MAB162

product name :

Human DC-SIGNR/CD299 Antibody

unit size :

500 ug (also 25 ug)

seo description :

The Human DC-SIGNR/CD299 Antibody from R&D Systems is a mouse monoclonal antibody to DC-SIGNR/CD299/CLEC4M. This antibody reacts with human,primate - cercopithecus aethiops (african green monkey). The Human DC-SIGNR/CD299 Antibody has been validated for the following applications: Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Adhesion Blockade,CyTOF-ready.

target :

DC-SIGNR/CD299

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

120604

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, Adhesion Blockade 2.5 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

NIH-3T3 mouse embryonic fibroblast cell line transfected with human DC-SIGNR/CD299, Accession # Q9H2X3

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Primate - Cercopithecus aethiops (African Green Monkey)

specificity :

Detects human DC-SIGNR/CD299.

gene symbol :

CLEC4M

top caption :

Detection of DC-SIGNR/CD299 antibody in Human DC-SIGNR/CD299 Transfected 3T3 Mouse Cell Line antibody by Flow Cytometry.

accessionNumbers :

Q9H2X3

applications :

Adhesion Blockade,CyTOF-ready,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry

extended description :

Clone 120604 was used by HLDA to establish CD designation

USD :

559 USD

product details :

Clone 120604 was used by HLDA to establish CD designation

alt names :

CD209L, CD209L1, CD209Ldendritic cell-specific ICAM-3-grabbing nonintegrin 2, CD299, CD299 antigenMGC129964, CLEC4M, C-type lectin domain family 4, member M, DC-SIGN2, DC-SIGN2CD209 antigen-like protein 1, DCSIGNR, DC-SIGNRDC-SIGN-related protein, DCSIGNRMGC47866, Dendritic cell-specific ICAM-3-grabbing non-integrin 2, HP10347, liver/lymph node-specific ICAM-3 grabbing non-integrin, Liver/lymph node-specific ICAM-3-grabbing non-integrin, LSIGN, L-SIGN, LSIGNC-type lectin domain family 4 member M, mannose binding C-type lectin DC-SIGNR

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage