Human DC-SIGN/CD209 Antibody | R&D Systems MAB161 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human DC-SIGN/CD209 Antibody

catalog :

MAB161

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

120507

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, blocking or activating experiments

citations: 40

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; rat; loading ...; fig 2h	Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, et al. Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release. Sci Rep. 2016;6:36222 pubmed publisher
	Vogt M, Lahon A, Arya R, Spencer Clinton J, Rico Hesse R. Dengue viruses infect human megakaryocytes, with probable clinical consequences. PLoS Negl Trop Dis. 2019;13:e0007837 pubmed publisher
	Xie M, Leroy H, Mascarau R, Woottum M, Dupont M, Ciccone C, et al. Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction. MBio. 2019;10: pubmed publisher
	Faure A, Hayes M, Sugden B. How Kaposi's sarcoma-associated herpesvirus stably transforms peripheral B cells towards lymphomagenesis. Proc Natl Acad Sci U S A. 2019;116:16519-16528 pubmed publisher
	Márquez S, Fernández J, Mancebo C, Herrero Sanchez C, Alonso S, Sandoval T, et al. Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns. Cell Rep. 2019;27:525-536.e4 pubmed publisher
	Fedeli C, Torriani G, Galan Navarro C, Moraz M, Moreno H, Gerold G, et al. Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan. J Virol. 2018;92: pubmed publisher
	Rappocciolo G, Jais M, Piazza P, DeLucia D, Jenkins F, Rinaldo C. Human Herpesvirus 8 Infects and Replicates in Langerhans Cells and Interstitial Dermal Dendritic Cells and Impairs Their Function. J Virol. 2017;91: pubmed publisher
	Dixon K, O Flynn J, Klar Mohamad N, Daha M, van Kooten C. Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-?. Eur J Immunol. 2017;47:470-480 pubmed publisher
	Smith I, Baker A, Christensen J, Boekhout T, Frøkiær H, Arneborg N, et al. Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro. PLoS ONE. 2016;11:e0167410 pubmed publisher
	SzatmÃ¡ri TÃ³th M, KristÃ³f E, VerÃ©b Z, Akhtar S, FacskÃ³ A, FÃ©sÃ¼s L, et al. Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration. Cell Death Dis. 2016;7:e2367 pubmed publisher
	Zhang Y, El Far M, Dupuy F, Abdel Hakeem M, He Z, Procopio F, et al. HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses. Sci Rep. 2016;6:29447 pubmed publisher
	Fernandes R, Bachiega T, Rodrigues D, Golim M, Dias Melício L, Balderramas H, et al. Paracoccidioides brasiliensis interferes on dendritic cells maturation by inhibiting PGE2 production. PLoS ONE. 2015;10:e0120948 pubmed publisher
	El Awady A, Miles B, Scisci E, Kurago Z, Palani C, Arce R, et al. Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk. PLoS Pathog. 2015;10:e1004647 pubmed publisher
	Cerny D, Haniffa M, Shin A, Bigliardi P, Tan B, Lee B, et al. Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection. PLoS Pathog. 2014;10:e1004548 pubmed publisher
	Rennick L, de Vries R, Carsillo T, Lemon K, van Amerongen G, Ludlow M, et al. Live-attenuated measles virus vaccine targets dendritic cells and macrophages in muscle of nonhuman primates. J Virol. 2015;89:2192-200 pubmed publisher
	Ferguson D, Mattiuzzo G, Ham C, Stebbings R, Li B, Rose N, et al. Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues. PLoS ONE. 2014;9:e104390 pubmed publisher
	Beck Z, Jagodzinski L, Eller M, Thelian D, Matyas G, Kunz A, et al. Platelets and erythrocyte-bound platelets bind infectious HIV-1 in plasma of chronically infected patients. PLoS ONE. 2013;8:e81002 pubmed publisher
	Hesse C, Ginter W, Förg T, Mayer C, Baru A, Arnold Schrauf C, et al. In vivo targeting of human DC-SIGN drastically enhances CD8? T-cell-mediated protective immunity. Eur J Immunol. 2013;43:2543-53 pubmed publisher
	Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood. 2013;121:95-106 pubmed publisher
	Emara M, Royer P, Mahdavi J, Shakib F, Ghaemmaghami A. Retagging identifies dendritic cell-specific intercellular adhesion molecule-3 (ICAM3)-grabbing non-integrin (DC-SIGN) protein as a novel receptor for a major allergen from house dust mite. J Biol Chem. 2012;287:5756-63 pubmed publisher
	Johnson T, McLellan J, Graham B. Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2. J Virol. 2012;86:1339-47 pubmed publisher
	Sabatte J, Faigle W, Ceballos A, Morelle W, Rodríguez Rodrígues C, Remes Lenicov F, et al. Semen clusterin is a novel DC-SIGN ligand. J Immunol. 2011;187:5299-309 pubmed publisher
	Hirbod T, Kaldensjö T, Broliden K. In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa. PLoS ONE. 2011;6:e25551 pubmed publisher
	Bond E, Liang F, Sandgren K, Smed Sorensen A, Bergman P, Brighenti S, et al. Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations. J Invest Dermatol. 2012;132:114-23 pubmed publisher
	Jain P, Manuel S, Khan Z, Ahuja J, Quann K, Wigdahl B. DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells. J Virol. 2009;83:10908-21 pubmed publisher
	Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S. Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation. Blood. 2009;113:5157-66 pubmed publisher
	Kobayashi A, Weinberg V, Darragh T, Smith McCune K. Evolving immunosuppressive microenvironment during human cervical carcinogenesis. Mucosal Immunol. 2008;1:412-20 pubmed publisher
	Iyori M, Ohtani M, Hasebe A, Totsuka Y, Shibata K. A role of the Ca2+ binding site of DC-SIGN in the phagocytosis of E. coli. Biochem Biophys Res Commun. 2008;377:367-372 pubmed publisher
	Nonaka M, Ma B, Murai R, Nakamura N, Baba M, Kawasaki N, et al. Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells. J Immunol. 2008;180:3347-56 pubmed
	Wang J, Zhang Y, Wei J, Zhang X, Zhang B, Zhu Z, et al. Lewis X oligosaccharides targeting to DC-SIGN enhanced antigen-specific immune response. Immunology. 2007;121:174-82 pubmed
	Lai W, Sun P, Zhang J, Jennings A, Lalor P, Hubscher S, et al. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am J Pathol. 2006;169:200-8 pubmed
	Okuma K, Boritz E, Walker J, Sarkar A, Alexander L, Rose J. Recombinant vesicular stomatitis viruses encoding simian immunodeficiency virus receptors target infected cells and control infection. Virology. 2006;346:86-97 pubmed
	Terme M, Borg C, Guilhot F, Masurier C, Flament C, Wagner E, et al. BCR/ABL promotes dendritic cell-mediated natural killer cell activation. Cancer Res. 2005;65:6409-17 pubmed
	Beatty J, Islam S, North M, Knight S, Ogden C. Urine dendritic cells: a noninvasive probe for immune activity in bladder cancer?. BJU Int. 2004;94:1377-83 pubmed
	Arrighi J, Pion M, Garcia E, Escola J, van Kooyk Y, Geijtenbeek T, et al. DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. J Exp Med. 2004;200:1279-88 pubmed
	Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, et al. NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs. Blood. 2004;104:3267-75 pubmed
	Gardner L, Moffett A. Dendritic cells in the human decidua. Biol Reprod. 2003;69:1438-46 pubmed
	Tassaneetrithep B, Burgess T, Granelli Piperno A, Trumpfheller C, Finke J, Sun W, et al. DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells. J Exp Med. 2003;197:823-9 pubmed
	Tailleux L, Schwartz O, Herrmann J, Pivert E, Jackson M, Amara A, et al. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med. 2003;197:121-7 pubmed
	Wu L, Bashirova A, Martin T, Villamide L, Mehlhop E, Chertov A, et al. Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Proc Natl Acad Sci U S A. 2002;99:1568-73 pubmed

product information

brand :

R&D Systems

master code :

MAB161

SKU :

MAB161-100

product name :

Human DC-SIGN/CD209 Antibody

description :

The Human DC-SIGN/CD209 Antibody from R&D Systems is a mouse monoclonal antibody to DC-SIGN/CD209. This antibody reacts with human. The Human DC-SIGN/CD209 Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Adhesion Blockade, Immunocytochemistry, CyTOF-ready.

target :

DC-SIGN/CD209

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

120507

conjugate :

Unconjugated

host :

Mouse

immunogen :

NIH-3T3 mouse embryonic fibroblast cell line transfected with human DC-SIGN/CD209

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human DC-SIGN/CD209 on transfected NIH/3T3 cells and on monocyte derived dendritic cells. Does not react with parental mouse cells or irrelevant transfectants, such as human DC-SIGN2.

gene symbol :

CD209

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB161

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Adhesion Blockade, Immunocytochemistry, CyTOF-ready

extended description :

Clone 120507 was used by HLDA to establish CD designation

2020 USD :

339

2021 USD :

369 USD

product details :

Clone 120507 was used by HLDA to establish CD designation

alt names :

CD209, CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin, CD209 molecule, CDSIGNHIV gpl20-binding protein, CLEC4L, CLEC4LC-type lectin domain family 4 member L, DCSIGN, DC-SIGN1, DC-SIGN1C-type lectin domain family 4, member L, DC-SIGNMGC129965, Dendritic cell-specific ICAM-3-grabbing non-integrin 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.