Human CXCR3 Antibody | R&D Systems MAB160-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR3 Antibody

catalog :

MAB160-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

49801

reactivity :

human, mouse, rat, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 71

Reference
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Dangaj D, Bruand M, Grimm A, Ronet C, Barras D, Duttagupta P, et al. Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors. Cancer Cell. 2019;35:885-900.e10 pubmed publisher
Lande R, LEE E, Palazzo R, Marinari B, Pietraforte I, Santos G, et al. CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis. Nat Commun. 2019;10:1731 pubmed publisher
Zhang M, Deng X, Guan X, Geng L, Fu M, Zhang B, et al. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. Front Immunol. 2018;9:2932 pubmed publisher
Maricic I, Marrero I, Eguchi A, Nakamura R, Johnson C, Dasgupta S, et al. Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. J Immunol. 2018;201:3017-3035 pubmed publisher
Fox J, Kausar F, Day A, Osborne M, Hussain K, Mueller A, et al. CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration. Sci Rep. 2018;8:9466 pubmed publisher
Urra S, Fischer M, Martinez J, Veliz L, Orellana P, Solar A, et al. Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?. Oncotarget. 2018;9:2445-2467 pubmed publisher
Ishikawa T, Okayama T, Sakamoto N, Ideno M, Oka K, Enoki T, et al. Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer. Int J Cancer. 2018;142:2599-2609 pubmed publisher
Bellora F, Dondero A, Corrias M, Casu B, Regis S, Caliendo F, et al. Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages. J Immunol. 2017;199:1516-1525 pubmed publisher
Bronger H, Karge A, Dreyer T, Zech D, Kraeft S, Avril S, et al. Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncol Lett. 2017;13:4224-4230 pubmed publisher
Rahman N, Brauer P, Ho L, Usenko T, Tewary M, Zuniga Pflucker J, et al. Engineering the haemogenic niche mitigates endogenous inhibitory signals and controls pluripotent stem cell-derived blood emergence. Nat Commun. 2017;8:15380 pubmed publisher
Windmüller C, Zech D, Avril S, Boxberg M, Dawidek T, Schmalfeldt B, et al. CXCR3 mediates ascites-directed tumor cell migration and predicts poor outcome in ovarian cancer patients. Oncogenesis. 2017;6:e331 pubmed publisher
Han J, Suh C, Jung J, Ahn M, Han M, Kwon J, et al. Elevated circulating levels of the interferon-γ-induced chemokines are associated with disease activity and cutaneous manifestations in adult-onset Still's disease. Sci Rep. 2017;7:46652 pubmed publisher
Szczeklik W, Jakieła B, Wawrzycka Adamczyk K, Sanak M, Hubalewska Mazgaj M, Padjas A, et al. Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis. Eur J Immunol. 2017;47:724-733 pubmed publisher
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
Shang L, Duan L, Perkey K, Wietgrefe S, Zupancic M, Smith A, et al. Epithelium-innate immune cell axis in mucosal responses to SIV. Mucosal Immunol. 2017;10:508-519 pubmed publisher
Sun K, Sun G, Wu Y, Ko B, Hsu H, Wu S. TNF-? augments CXCR2 and CXCR3 to promote progression of renal cell carcinoma. J Cell Mol Med. 2016;20:2020-2028 pubmed publisher
Karjalainen M, Ojaniemi M, Haapalainen A, Mahlman M, Salminen A, Huusko J, et al. CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth. J Immunol. 2015;195:2187-98 pubmed publisher
Wightman S, Uppal A, Pitroda S, Ganai S, Burnette B, Stack M, et al. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. Br J Cancer. 2015;113:327-35 pubmed publisher
McCully M, Collins P, Hughes T, Thomas C, Billen J, O Donnell V, et al. Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells. J Immunol. 2015;195:96-104 pubmed publisher
Chung B, Arutyunov A, Ilagan E, Yao N, Wills Karp M, Coulombe P. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. J Cell Biol. 2015;208:613-27 pubmed publisher
Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, et al. The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clin Cancer Res. 2015;21:2840-50 pubmed publisher
Barnes J, Lumsden R, Worrell J, Counihan I, O Beirne S, Belperio J, et al. CXCR3 Requirement for the Interleukin-13-Mediated Up-Regulation of Interleukin-13RÎ±2 in Pulmonary Fibroblasts. Am J Respir Cell Mol Biol. 2015;53:217-25 pubmed publisher
Douthwaite J, Sridharan S, Huntington C, Hammersley J, Marwood R, Hakulinen J, et al. Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1. MAbs. 2015;7:152-66 pubmed publisher
Lunardi S, Jamieson N, Lim S, Griffiths K, Carvalho Gaspar M, Al Assar O, et al. IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget. 2014;5:11064-80 pubmed
Wheat R, Roberts C, Waterboer T, Steele J, Marsden J, Steven N, et al. Inflammatory cell distribution in primary merkel cell carcinoma. Cancers (Basel). 2014;6:1047-64 pubmed publisher
Falk M, Singh A, Faber C, Nissen M, Hviid T, Sørensen T. Dysregulation of CXCR3 expression on peripheral blood leukocytes in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55:4050-6 pubmed publisher
Carrega P, Bonaccorsi I, Di Carlo E, Morandi B, Paul P, Rizzello V, et al. CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph. J Immunol. 2014;192:3805-15 pubmed publisher
Bondar C, Araya R, Guzmán L, Rua E, Chopita N, Chirdo F. Role of CXCR3/CXCL10 axis in immune cell recruitment into the small intestine in celiac disease. PLoS ONE. 2014;9:e89068 pubmed publisher
Pinto S, Martinez Romero A, O Connor J, Gil Benso R, San Miguel T, Terrádez L, et al. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation. BMC Cancer. 2014;14:118 pubmed publisher
Castriconi R, Dondero A, Bellora F, Moretta L, Castellano A, Locatelli F, et al. Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells. J Immunol. 2013;190:5321-8 pubmed publisher
Aruga A, Takeshita N, Kotera Y, Okuyama R, Matsushita N, Ohta T, et al. Long-term Vaccination with Multiple Peptides Derived from Cancer-Testis Antigens Can Maintain a Specific T-cell Response and Achieve Disease Stability in Advanced Biliary Tract Cancer. Clin Cancer Res. 2013;19:2224-31 pubmed publisher
Chaturvedi P, Gilkes D, Wong C, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123:189-205 pubmed publisher
Sela H, Goldman Wohl D, Haimov Kochman R, Greenfield C, Natanson Yaron S, Hamani Y, et al. Human trophectoderm apposition is regulated by interferon γ-induced protein 10 (IP-10) during early implantation. Placenta. 2013;34:222-30 pubmed publisher
Vinet J, van Zwam M, Dijkstra I, Brouwer N, van Weering H, Watts A, et al. Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. Br J Pharmacol. 2013;168:1375-87 pubmed publisher
Stenton G, Mackenzie L, Tam P, Cross J, Harwig C, Raymond J, et al. Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol. 2013;168:1506-18 pubmed publisher
Green L, Petrusca D, Rajashekhar G, Gianaris T, Schweitzer K, Wang L, et al. Cigarette smoke-induced CXCR3 receptor up-regulation mediates endothelial apoptosis. Am J Respir Cell Mol Biol. 2012;47:807-14 pubmed publisher
Canals M, Scholten D, de Munnik S, Han M, Smit M, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE. 2012;7:e34192 pubmed publisher
Wu Q, Dhir R, Wells A. Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Mol Cancer. 2012;11:3 pubmed publisher
Pandya A, Al Jaderi Z, Høglund R, Holmøy T, Harbo H, Norgauer J, et al. Identification of human NK17/NK1 cells. PLoS ONE. 2011;6:e26780 pubmed publisher
Scholten D, Canals M, Wijtmans M, de Munnik S, Nguyen P, Verzijl D, et al. Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3. Br J Pharmacol. 2012;166:898-911 pubmed publisher
Caramori G, Lasagna L, Casalini A, Adcock I, Casolari P, Contoli M, et al. Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy. PLoS ONE. 2011;6:e22637 pubmed publisher
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
Busuttil A, Weigt S, Keane M, Xue Y, Palchevskiy V, Burdick M, et al. CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis. Eur Respir J. 2009;34:676-86 pubmed publisher
Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur J, Hollenberg M, et al. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J. 2009;23:2928-41 pubmed publisher
Kim M, Romero R, Kim C, Tarca A, Chhauy S, LaJeunesse C, et al. Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease. J Immunol. 2009;182:3919-27 pubmed publisher
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Meiser A, Mueller A, Wise E, McDonagh E, Petit S, Saran N, et al. The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor. J Immunol. 2008;180:6713-24 pubmed
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Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
Haas C, Martinez R, Attia N, Haines G, Campbell P, Koch A. Chemokine receptor expression in rat adjuvant-induced arthritis. Arthritis Rheum. 2005;52:3718-30 pubmed
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Lepej S, Rode O, Jeren T, Vince A, Remenar A, Barsic B. Increased expression of CXCR3 and CCR5 on memory CD4+ T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis: the role of CXCL10 and CXCL11. J Neuroimmunol. 2005;163:128-34 pubmed
Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, et al. Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum. 2005;52:1504-16 pubmed
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product information

brand :

R&D Systems

master code :

MAB160

SKU :

MAB160-100

product name :

Human CXCR3 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human CXCR3 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR3. This antibody reacts with feline,human,mouse,primate - macaca mulatta (rhesus macaque),rat. The Human CXCR3 Antibody has been validated for the following applications: Bioassay,Stimulation,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Cell Culture,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.

target :

CXCR3

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

49801

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Neutralization 0.3-1.5 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CXCR3, Met1-Leu368, Accession # P49682

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Feline,Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Rat

specificity :

Detects human CXCR3.

gene symbol :

CXCR3

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of CXCR3 antibody in Human PBMC Lymphocytes antibody by Flow Cytometry.

accessionNumbers :

P49682

applications :

CyTOF-ready,Bioassay,Stimulation,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,Functional Assay,Cell Culture

USD :

499 USD

alt names :

CD183, CD183 antigen, chemokine (C-X-C motif) receptor 3, chemokine (C-X-C) receptor 3, CKR-L2IP-10 receptor, CMKAR3, C-X-C chemokine receptor type 3, CXCR3, CXC-R3, CXCR-3, G protein-coupled receptor 9CD182, GPR9, GPR9Mig-R, Interferon-inducible protein 10 receptor, IP10 receptor, IP10-R, Mig receptor, MigR

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage