Human IL-29/IFN-lambda 1 Antibody | R&D Systems MAB15981-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-29/IFN-lambda 1 Antibody

catalog :

MAB15981-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

247801

reactivity :

human

application :

ELISA, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 15

Reference
Groen K, Kuratli R, Sar L, Vasou A, Huber M, Hughes D, et al. Highly sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies. Eur J Immunol. 2024;54:e2451325 pubmed publisher
Hong J, Lee J, Zhang Z, Wu Y, Yang M, Liao Y, et al. PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer. Cancer Res. 2022;82:4624-4640 pubmed publisher
Pang E, Daraj G, Balka K, De Nardo D, Macri C, Hochrein H, et al. Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations. Front Immunol. 2022;13:794776 pubmed publisher
Gruber C, Patel R, Trachtman R, Lepow L, Amanat F, Krammer F, et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Cell. 2020;183:982-995.e14 pubmed publisher
Essaidi Laziosi M, Geiser J, Huang S, Constant S, Kaiser L, Tapparel C. Interferon-Dependent and Respiratory Virus-Specific Interference in Dual Infections of Airway Epithelia. Sci Rep. 2020;10:10246 pubmed publisher
Oke V, Gunnarsson I, Dorschner J, Eketjäll S, Zickert A, Niewold T, et al. High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus. Arthritis Res Ther. 2019;21:107 pubmed publisher
Doganay S, Lee M, Baum A, Peh J, Hwang S, Yoo J, et al. Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression. Integr Biol (Camb). 2017;9:857-867 pubmed publisher
Oke V, Brauner S, Larsson A, Gustafsson J, Zickert A, Gunnarsson I, et al. IFN-?1 with Th17 axis cytokines and IFN-? define different subsets in systemic lupus erythematosus (SLE). Arthritis Res Ther. 2017;19:139 pubmed publisher
Zickert A, Oke V, Parodis I, Svenungsson E, Sundström Y, Gunnarsson I. Interferon (IFN)-λ is a potential mediator in lupus nephritis. Lupus Sci Med. 2016;3:e000170 pubmed
Villenave R, Broadbent L, Douglas I, Lyons J, Coyle P, Teng M, et al. Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium. J Virol. 2015;89:12309-18 pubmed publisher
Persson B, Jaffe A, Fearns R, Danahay H. Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. PLoS ONE. 2014;9:e102368 pubmed publisher
Brownell J, Bruckner J, Wagoner J, Thomas E, Loo Y, Gale M, et al. Direct, interferon-independent activation of the CXCL10 promoter by NF-?B and interferon regulatory factor 3 during hepatitis C virus infection. J Virol. 2014;88:1582-90 pubmed publisher
Brownell J, Wagoner J, Lovelace E, Thirstrup D, Mohar I, Smith W, et al. Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes. J Hepatol. 2013;59:701-8 pubmed publisher
Stone A, Giugliano S, Schnell G, Cheng L, Leahy K, Golden Mason L, et al. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013;9:e1003316 pubmed publisher
Yin Z, Dai J, Deng J, Sheikh F, Natalia M, Shih T, et al. Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells. J Immunol. 2012;189:2735-45 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB15981

SKU :

MAB15981-100

product name :

Human IL-29/IFN-lambda 1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human IL-29/IFN-lambda 1 Antibody from R&D Systems is a mouse monoclonal antibody to IL-29/IFN-lambda 1. This antibody reacts with human. The Human IL-29/IFN-lambda 1 Antibody has been validated for the following applications: Neutralization,Bioassay,ELISA Development (Capture),Flow Cytometry,ELISA Capture,ELISA Capture (Matched Antibody Pair).

target :

IL-29/IFN-lambda 1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

247801

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Neutralization 1-4 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-29/IFN-lambda 1, Gly20-Thr200, Accession # Q8IU54

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-29/IFN-lambda 1 in ELISAs. In sandwich immunoassays, 100% cross-reactivity with recombinant human (rh) IL-28B/IFN-lambda 3 and 20% with rhIL-28A is observed. No cross-reactivity or interference was observed with rhIFN-alpha A, rhIFN-alpha B2, rhIFN-alpha G, rhIFN-alpha I, or rhIFN┐▀1A.

gene symbol :

IFNL1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IL-29/IFN-?1 Inhibition of EMCV-induced Cytopathy and Neutralization by Human IL-29/IFN-?1 Antibody.

accessionNumbers :

Q8IU54

applications :

ELISA Capture (Matched Antibody Pair),Bioassay,ELISA Development (Capture),Flow Cytometry,Neutralization,ELISA Capture

USD :

479 USD

alt names :

cytokine Zcyto21, IFNL1, IFNl3, IFNlambda 1, IFN-lambda 1, IFNlambda 3, IFN-lambda 3, IFN-lambda-1, IL29, IL-29, interferon lambda-1, interferon, lambda 1, interleukin 29 (interferon, lambda 1), interleukin-29, ZCYTO21

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage