Human Notch-3 Antibody | R&D Systems MAB1559 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Notch-3 Antibody

catalog :

MAB1559

quantity :

100 ug (also 25 ug)

price :

429 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

603532

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, flow cytometry

more info or order :

R&D Systems product webpage

citations: 4

Reference
Oliveira D, Coupland K, Shao W, Jin S, Del Gaudio F, Wang S, et al. Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model. EMBO Mol Med. 2023;15:e16556 pubmed publisher
Kim H, Jang B, Kim Y, Choi J. Determination of Blood NOTCH3 Extracellular Domain and Jagged-1 Levels in Healthy Subjects. Int J Mol Sci. 2022;23: pubmed publisher
Machuca Parra A, Bigger Allen A, Sanchez A, Boutabla A, Cardona Vélez J, Amarnani D, et al. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. J Exp Med. 2017;214:2271-2282 pubmed publisher
Soriani A, Iannitto M, Ricci B, Fionda C, Malgarini G, Morrone S, et al. Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. J Immunol. 2014;193:950-60 pubmed publisher

product information

master code :

MAB1559

SKU :

MAB1559

product name :

Human Notch-3 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Notch-3 Antibody from R&D Systems is a mouse monoclonal antibody to Notch-3. This antibody reacts with human,mouse. The Human Notch-3 Antibody has been validated for the following applications: Flow Cytometry,ELISA Capture,Immunohistochemistry,CyTOF-ready.

target :

Notch-3

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

603532

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Notch-3, Ala40-Glu467, Accession # Q9UM47

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human Notch-3 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Notch-3 ICD (aa 2195-2321), rhNotch-1, rhNotch-1 ICD (aa 2251-2556), rhNotch-2, rhNotch-2 ICD (aa 2063-2413), rhNotch-4, rhNotch-4 ICD (aa 1778-2003), recombinant mouse Notch-3, or recombinant rat DLL1 is observed.

gene symbol :

NOTCH3

top caption :

Detection of Notch-3 antibody in BG01V Human Stem Cells antibody by Flow Cytometry.

accessionNumbers :

Q9UM47

applications :

Flow Cytometry,ELISA Capture,Immunohistochemistry,CyTOF-ready

USD :

429 USD

alt names :

CADASIL, CASILneurogenic locus notch homolog protein 3, Notch (Drosophila) homolog 3, notch 3Notch homolog 3 (Drosophila), Notch homolog 3, Notch3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage