Human CCR3 Antibody | R&D Systems MAB155-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR3 Antibody

catalog :

MAB155-100

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

61828

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 20

Reference
Kaibori Y, Nagakubo D. CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines. Cancer Gene Ther. 2023;30:137-148 pubmed publisher
Mladinich M, Conde J, Schutt W, Sohn S, Mackow E. Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells. MBio. 2021;12:e0196221 pubmed publisher
Segal Salto M, Barashi N, Katav A, Edelshtein V, Aharon A, Hashmueli S, et al. A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage. JHEP Rep. 2020;2:100064 pubmed publisher
Williams A, José R, Mercer P, Brealey D, Parekh D, Thickett D, et al. Evidence for chemokine synergy during neutrophil migration in ARDS. Thorax. 2017;72:66-73 pubmed publisher
Huang G, Tao L, Shen S, Chen L. Hypoxia induced CCL28 promotes angiogenesis in lung adenocarcinoma by targeting CCR3 on endothelial cells. Sci Rep. 2016;6:27152 pubmed publisher
Tian M, Chen L, Ma L, Wang D, Shao B, Wu J, et al. Expression and prognostic significance of CCL11/CCR3 in glioblastoma. Oncotarget. 2016;7:32617-27 pubmed publisher
Facciabene A, Peng X, Hagemann I, Balint K, Barchetti A, Wang L, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature. 2011;475:226-30 pubmed publisher
Jung D, Che Z, Kim J, Kim K, Kim K, Williams D, et al. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int J Cancer. 2010;127:332-44 pubmed publisher
Hartl D, Krauss Etschmann S, Koller B, Hordijk P, Kuijpers T, Hoffmann F, et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol. 2008;181:8053-67 pubmed
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
Yuan Q, Campanella G, Colvin R, Hamilos D, Jones K, Mathew A, et al. Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells. Eur J Immunol. 2006;36:2700-14 pubmed
Beck L, Tancowny B, Brummet M, Asaki S, Curry S, Penno M, et al. Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. J Immunol. 2006;177:3344-54 pubmed
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
Spencer L, Melo R, Perez S, Bafford S, Dvorak A, Weller P. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion. Proc Natl Acad Sci U S A. 2006;103:3333-8 pubmed
Puxeddu I, Bader R, Piliponsky A, Reich R, Levi Schaffer F, Berkman N. The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J Allergy Clin Immunol. 2006;117:103-10 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Annels N, Willemze A, van der Velden V, Faaij C, van Wering E, Sie Go D, et al. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004;103:2806-8 pubmed
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle M, et al. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J Leukoc Biol. 2003;73:584-90 pubmed
Howard O, Dong H, Yang D, Raben N, Nagaraju K, Rosen A, et al. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med. 2002;196:781-91 pubmed
de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M. Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. Eur J Immunol. 2001;31:1037-46 pubmed

product information

brand :

R&D Systems

master code :

MAB155

SKU :

MAB155-100

product name :

Human CCR3 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human CCR3 Antibody from R&D Systems is a rat monoclonal antibody to CCR3. This antibody reacts with human,mouse. The Human CCR3 Antibody has been validated for the following applications: Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.

target :

CCR3

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

61828

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Neutralization 0.05-0.25 ug/mL, CyTOF-ready

host :

Rat

immunogen :

Y3 rat myeloid cell line transfected with human CCR3, Accession # P51677

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human CCR3 transfectants in flow cytometry. In flow cytometry, no cross-reactivity with CCR1, CCR2, CCR5, and CCR6 transfectants or the parental cell line is observed. Detects CCR3 on peripheral blood eosinophils.

gene symbol :

CCR3

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

CCR3 antibody in Human Lymph Node by Immunohistochemistry (IHC-P).

accessionNumbers :

P51677

applications :

CyTOF-ready,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry

extended description :

Clone 61828 was used by HLDA to establish CD designation

USD :

479 USD

product details :

Clone 61828 was used by HLDA to establish CD designation

alt names :

b-chemokine receptor, CC chemokine receptor 3, C-C chemokine receptor type 3, C-C CKR-3, CCR3, CCR-3, CD193, CD193 antigen, chemokine (C-C motif) receptor 3, CKR3CC-CKR-3CMKBR3CD193, eosinophil CC chemokine receptor 3, Eosinophil eotaxin receptor, MGC102841

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage