Mouse NKG2D/CD314 Antibody | R&D Systems MAB1547-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse NKG2D/CD314 Antibody

catalog :

MAB1547-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

191004

reactivity :

human

application :

western blot, immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 20

Reference
Perez C, Plaza Rojas L, Boucher J, Nagy M, Kostenko E, Prajapati K, et al. NKG2D receptor signaling shapes T cell thymic education. J Leukoc Biol. 2024;115:306-321 pubmed publisher
Peauroi E, Carro S, Pei L, Reynoso G, Hickman H, Eisenlohr L. The ectromelia virus virulence factor C15 facilitates early viral spread by inhibiting NK cell contact. iScience. 2022;25:105510 pubmed publisher
Shimada A, Toda K, Inoue I, Yamada T, Oikawa Y. Combination of anti-CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as 'pregnancy-related' type 1 diabetes model. J Diabetes Investig. 2022;13:1489-1495 pubmed publisher
Meléndez E, Chondronasiou D, Mosteiro L, Mart xed nez de Villarreal J, Fern xe1 ndez Alfara M, Lynch C, et al. Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Development. 2022;149: pubmed publisher
Wirsching H, Zhang H, Szulzewsky F, Arora S, Grandi P, Cimino P, et al. Arming oHSV with ULBP3 drives abscopal immunity in lymphocyte-depleted glioblastoma. JCI Insight. 2019;4: pubmed publisher
Shen J, Pan J, Du C, Si W, Yao M, Xu L, et al. Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer. Cell Death Dis. 2017;8:e2740 pubmed publisher
Qian L, Liu Y, Wang S, Gong W, Jia X, Liu L, et al. NKG2D ligand RAE1? induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice. J Cell Mol Med. 2017;21:2046-2054 pubmed publisher
Ham H, Huynh W, Schoon R, Vale R, Billadeau D. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol. 2015;194:3984-96 pubmed publisher
Nielsen M, Dyring Andersen B, Schmidt J, Witherden D, Lovato P, Woetmann A, et al. NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity. J Invest Dermatol. 2015;135:1311-1319 pubmed publisher
Coursey T, Bohat R, Barbosa F, Pflugfelder S, de Paiva C. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-Î³ in experimental dry eye. J Immunol. 2014;193:5264-72 pubmed publisher
Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara Takeuchi A, Kuroki K, et al. NKG2D triggers cytotoxicity in murine epidermal ?? T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway. J Invest Dermatol. 2014;134:396-404 pubmed publisher
Kim M, Park H, Seol J, Jang J, Cho Y, Kim K, et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013;5:1415-30 pubmed publisher
Hosomi S, Chen Z, Baker K, Chen L, Huang Y, Olszak T, et al. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013;43:2473-83 pubmed publisher
Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, et al. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Mucosal Immunol. 2012;5:702-11 pubmed publisher
Li Z, Zhang C, Zhou Z, Zhang J, Zhang J, Tian Z. Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor ?? are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection. Infect Immun. 2012;80:565-74 pubmed publisher
Slavuljica I, Busche A, Babic M, Mitrovic M, Gašparović I, Cekinović D, et al. Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties. J Clin Invest. 2010;120:4532-45 pubmed publisher
Lundqvist A, Yokoyama H, Smith A, Berg M, Childs R. Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells. Blood. 2009;113:6120-7 pubmed publisher
Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, et al. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D. J Immunol. 2008;180:1678-85 pubmed
Bahjat K, Prell R, Allen H, Liu W, Lemmens E, Leong M, et al. Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease. J Immunol. 2007;179:7376-84 pubmed
Giroux M, Yurchenko E, St Pierre J, Piccirillo C, Perreault C. T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol. 2007;179:4492-502 pubmed

product information

master code :

MAB1547

SKU :

MAB1547-100

product name :

Mouse NKG2D/CD314 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse NKG2D/CD314 Antibody from R&D Systems is a rat monoclonal antibody to NKG2D/CD314. This antibody reacts with human,mouse,transgenic mouse. The Mouse NKG2D/CD314 Antibody has been validated for the following applications: Bioassay,Neutralization,Western Blot,Functional Assay,Immunohistochemistry,Immunohistochemistry-Frozen,Flow Cytometry,Blockade of Receptor-ligand Interaction,CyTOF-ready.

target :

NKG2D/CD314

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

191004

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse NKG2D, Phe94-Val232, Accession # O54709

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects mouse NKG2D in direct ELISAs and Western blots. Does not cross-react with recombinant human NKG2D.

gene symbol :

KLRK1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

accessionNumbers :

O54709

applications :

Neutralization,Bioassay,Western Blot,Functional Assay,Immunohistochemistry,Immunohistochemistry-Frozen,Flow Cytometry,Blockade of Receptor-ligand Interaction,CyTOF-ready

USD :

469 USD

alt names :

CD314, CD314 antigen, D12S2489E, FLJ17759, FLJ75772, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K, member 1, KLR, KLRK1, NK cell receptor D, NKG2-D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2DDNA segment on chromosome 12 (unique) 2489 expressed sequence

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage