Human Axl Antibody | R&D Systems MAB154-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Axl Antibody

catalog :

MAB154-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

108724

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 31

Reference
Creixell M, Taylor S, Gerritsen J, Bae S, Jiang M, Augustin T, et al. Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations. bioRxiv. 2023;: pubmed publisher
Sulczewski F, Maqueda Alfaro R, Alc xe1 ntara Hern xe1 ndez M, Perez O, Saravanan S, Yun T, et al. Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses. Nat Immunol. 2023;24:1265-1280 pubmed publisher
Poler xe0 N, Mancuso A, Riillo C, Caracciolo D, Signorelli S, Grillone K, et al. The First-In-Class Anti-AXL×CD3ε Pronectin™-Based Bispecific T-Cell Engager Is Active in Preclinical Models of Human Soft Tissue and Bone Sarcomas. Cancers (Basel). 2023;15: pubmed publisher
Quah H, Cao E, Suteja L, Li C, Leong H, Chong F, et al. Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis. Nat Commun. 2023;14:1680 pubmed publisher
Rios Doria J, Favata M, Lasky K, Feldman P, Lo Y, Yang G, et al. A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity. Front Oncol. 2020;10:598477 pubmed publisher
Gabaev I, Williamson J, Crozier T, Schulz T, Lehner P. Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation. Cell Rep. 2020;33:108249 pubmed publisher
Leylek R, Alcántara Hernández M, Granja J, Chavez M, Perez K, Diaz O, et al. Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity. Cell Rep. 2020;32:108180 pubmed publisher
Rossi F, Josey B, Sayitoglu E, Potens R, Sultu T, Duru A, et al. Characterization of zika virus infection of human fetal cardiac mesenchymal stromal cells. PLoS ONE. 2020;15:e0239238 pubmed publisher
Gruber C, Calis J, Buta S, Evrony G, Martin J, Uhl S, et al. Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function. Immunity. 2020;53:672-684.e11 pubmed publisher
Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, et al. Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans. Immunity. 2020;53:353-370.e8 pubmed publisher
Martín Fernandez M, Bravo García Morato M, Gruber C, Murias Loza S, Malik M, Alsohime F, et al. Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions. Cell Rep. 2020;31:107633 pubmed publisher
Michlmayr D, Kim E, Rahman A, Raghunathan R, Kim Schulze S, Che Y, et al. Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection. Cell Rep. 2020;31:107569 pubmed publisher
Lotsberg M, Wnuk Lipinska K, Terry S, Tan T, Lu N, Trachsel Moncho L, et al. AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. J Thorac Oncol. 2020;15:973-999 pubmed publisher
Kedage V, Ellerman D, Chen Y, Liang W, Borneo J, Wu Y, et al. Harnessing MerTK agonism for targeted therapeutics. MAbs. 2020;12:1685832 pubmed publisher
Peeters M, Dulkeviciute D, Draghi A, Ritter C, Rahbech A, Skadborg S, et al. MERTK Acts as a Costimulatory Receptor on Human CD8+ T Cells. Cancer Immunol Res. 2019;7:1472-1484 pubmed publisher
Lauter M, Weber A, Torka R. Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation. Cell Commun Signal. 2019;17:59 pubmed publisher
Claas A, Atta L, Gordonov S, Meyer A, Lauffenburger D. Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition. Cell Mol Bioeng. 2018;11:451-469 pubmed publisher
Zweemer A, French C, Mesfin J, Gordonov S, Meyer A, Lauffenburger D. Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Mol Cancer Res. 2017;15:1656-1666 pubmed publisher
Pagani I, Ghezzi S, Ulisse A, Rubio A, Turrini F, Garavaglia E, et al. Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus. Sci Rep. 2017;7:44286 pubmed publisher
Meyer A, Zweemer A, Lauffenburger D. The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity. Cell Syst. 2015;1:25-36 pubmed
Cerny D, Haniffa M, Shin A, Bigliardi P, Tan B, Lee B, et al. Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection. PLoS Pathog. 2014;10:e1004548 pubmed publisher
Micklem D, Blø M, Bergström P, Hodneland E, Tiron C, Høiby T, et al. Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets. BMC Biotechnol. 2014;14:57 pubmed publisher
D Alfonso T, Hannah J, Chen Z, Liu Y, Zhou P, Shin S. Axl receptor tyrosine kinase expression in breast cancer. J Clin Pathol. 2014;67:690-6 pubmed publisher
Zizzo G, Guerrieri J, Dittman L, Merrill J, Cohen P. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther. 2013;15:R212 pubmed
Bauer T, Zagorska A, Jurkin J, Yasmin N, Köffel R, Richter S, et al. Identification of Axl as a downstream effector of TGF-?1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med. 2012;209:2033-47 pubmed publisher
Shimojima M, Stroher U, Ebihara H, Feldmann H, Kawaoka Y. Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry. J Virol. 2012;86:2067-78 pubmed publisher
Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi J, Nevo J, Gjerdrum C, et al. Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene. 2011;30:1436-48 pubmed publisher
Zhu D, Wang Y, Singh I, Bell R, Deane R, Zhong Z, et al. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010;115:4963-72 pubmed publisher
Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, et al. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway. J Immunol. 2009;183:3004-13 pubmed publisher
Weinger J, Omari K, Marsden K, Raine C, Shafit Zagardo B. Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. Am J Pathol. 2009;175:283-93 pubmed publisher
Holland S, Powell M, Franci C, Chan E, Friera A, Atchison R, et al. Multiple roles for the receptor tyrosine kinase axl in tumor formation. Cancer Res. 2005;65:9294-303 pubmed

product information

master code :

MAB154

SKU :

MAB154-100

product name :

Human Axl Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human Axl Antibody from R&D Systems is a mouse monoclonal antibody to Axl. This antibody reacts with human. The Human Axl Antibody has been validated for the following applications: Flow Cytometry,Immunohistochemistry,Western Blot,CyTof,Cell Selection,ELISA Capture,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Knockout Validated.

target :

Axl

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

108724

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Axl, Met1-Pro440, Accession # AAA61243

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Axl in direct ELISAs. In direct ELISAs, this antibody shows no cross-reactivity with recombinant mouse Axl, recombinant human (rh) Dtk or rhMer.

gene symbol :

AXL

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Axl antibody in HeLa Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

AAA61243

applications :

Immunohistochemistry,Western Blot,CyTof,Flow Cytometry,Cell Selection,ELISA Capture,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Knockout Validated

USD :

489 USD

alt names :

AI323647, ARK, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, EC 2.7.10, EC 2.7.10.1, JTK11, Tyro7, tyrosine-protein kinase receptor UFO, UFO, UFOoncogene AXL

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage