Human IL-12/IL-23 p40 Antibody | R&D Systems MAB1510-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-12/IL-23 p40 Antibody

catalog :

MAB1510-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24901

reactivity :

human, mouse

application :

ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 13

Reference
Guo Y, Chomiak A, Hong Y, Lowe C, Kopsidas C, Chan W, et al. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration. iScience. 2022;25:104519 pubmed publisher
Chomiak A, Guo Y, Kopsidas C, McDaniel D, Lowe C, Pan H, et al. Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022;25:104354 pubmed publisher
Rademacher M, Cruz A, Faber M, Oldham R, Wang D, Medin J, et al. Sarcoma IL-12 overexpression facilitates NK cell immunomodulation. Sci Rep. 2021;11:8321 pubmed publisher
Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed publisher
van der Kant R, Langness V, Herrera C, Williams D, Fong L, Leestemaker Y, et al. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019;24:363-375.e9 pubmed publisher
Abumaree M, Bahattab E, Alsadoun A, Al Dosaimani A, Abomaray F, Khatlani T, et al. Characterization of the interaction between human decidua parietalis mesenchymal stem/stromal cells and natural killer cells. Stem Cell Res Ther. 2018;9:102 pubmed publisher
Packer M, Rees H, Liu D. Phage-assisted continuous evolution of proteases with altered substrate specificity. Nat Commun. 2017;8:956 pubmed publisher
Sommer A, Fabri M. Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. PLoS ONE. 2015;10:e0130395 pubmed publisher
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, et al. Tumor-activated TCR??? T cells from gastric cancer patients induce the antitumor immune response of TCR??? T cells via their antigen-presenting cell-like effects. J Immunol Res. 2014;2014:593562 pubmed publisher
Olson B, Jankowska Gan E, Becker J, Vignali D, Burlingham W, McNeel D. Human prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade. J Immunol. 2012;189:5590-601 pubmed publisher
Mabry R, Lewis K, Moore M, McKernan P, Bukowski T, Bontadelli K, et al. Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng Des Sel. 2010;23:115-27 pubmed publisher
Rao D, Tracey K, Pober J. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J Immunol. 2007;179:6536-46 pubmed
Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, et al. Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism. J Immunol. 2005;174:2376-86 pubmed

product information

master code :

MAB1510

SKU :

MAB1510-100

product name :

Human IL-12/IL-23 p40 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human IL-12/IL-23 p40 Antibody from R&D Systems is a mouse monoclonal antibody to IL-12/IL-23 p40. This antibody reacts with human,mouse. The Human IL-12/IL-23 p40 Antibody has been validated for the following applications: Neutralization,Functional Assay,ELISA Capture.

target :

IL-12/IL-23 p40

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

24901

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-12 p40/p35 heterodimer

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human IL-12 (p40/p35 heterodimer), IL-23 (p40/p19 heterodimer), and p40 homodimers in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant mouse (rm) IL-12 p40 or rpIL-12.

gene symbol :

IL12B

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IL-17 Secretion Induced by IL-23 and Neutralization by Human IL-12/IL-23 p40 Antibody.

applications :

Neutralization,Functional Assay,ELISA Capture

USD :

489 USD

alt names :

CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL12 p40, IL-12 subunit p40, IL12B, IL-12B, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2, NKSF2IL12, subunit p40

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage