Human LRP-6 Antibody | R&D Systems MAB1505 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human LRP-6 Antibody

catalog :

MAB1505

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

255302

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

R&D Systems product webpage

citations: 7

Reference
Mukherjee S, Maddalena M, Lu Y, Martinez S, Nataraj N, Noronha A, et al. Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins. Proc Natl Acad Sci U S A. 2022;119:e2119644119 pubmed publisher
Yu A, Li Y, Li I, Ozawa M, Yeh C, Chiou A, et al. Reconstructing codependent cellular cross-talk in lung adenocarcinoma using REMI. Sci Adv. 2022;8:eabi4757 pubmed publisher
Chen G, Tifrea D, Murad R, Habowski A, Lyou Y, Duong M, et al. Disruption of β-Catenin-Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion. Mol Cancer Res. 2021;: pubmed publisher
Agajanian M, Walker M, Axtman A, Ruela de Sousa R, Serafin D, Rabinowitz A, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26:79-93.e8 pubmed publisher
Berger B, Acebron S, Herbst J, Koch S, Niehrs C. Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6. EMBO Rep. 2017;18:712-725 pubmed publisher
Madan B, Walker M, Young R, Quick L, Orgel K, Ryan M, et al. USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proc Natl Acad Sci U S A. 2016;113:E2945-54 pubmed publisher
Hao H, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012;485:195-200 pubmed publisher

product information

master code :

MAB1505

SKU :

MAB1505

product name :

Human LRP-6 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human LRP-6 Antibody from R&D Systems is a mouse monoclonal antibody to LRP-6. This antibody reacts with human. The Human LRP-6 Antibody has been validated for the following applications: Immunohistochemistry,Flow Cytometry,Immunocytochemistry,CyTOF-ready.

target :

LRP-6

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

255302

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human LRP-6, Ala20-Pro1368, Accession # O75581

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human LRP-6 in direct ELISAs. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) LRP-6 and no cross-reactivity with recombinant human (rh) LRP-1, -4, -5, rhLRP-6 (intracellular domain), or rhLDL R is observed.

gene symbol :

LRP6

top caption :

Detection of LRP-6 antibody in MDA- MB-231 Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

O75581

applications :

Immunohistochemistry,Flow Cytometry,Immunocytochemistry,CyTOF-ready

USD :

469 USD

alt names :

ADCAD2, FLJ90062, FLJ90421, low density lipoprotein receptor-related protein 6, low-density lipoprotein receptor-related protein 6, LRP6, LRP-6

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage