Human CCR2 Antibody | R&D Systems MAB150 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR2 Antibody

catalog :

MAB150

quantity :

100 ug (also 25 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

48607

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 40

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig e10g	Ramachandran P, Dobie R, Wilson Kanamori J, Dora E, Henderson B, Luu N, et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature. 2019;575:512-518 pubmed publisher
immunohistochemistry - paraffin section; human; 1:400; loading ...; fig s4b	Cassetta L, Fragkogianni S, Sims A, Swierczak A, Forrester L, Zhang H, et al. Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer Cell. 2019;35:588-602.e10 pubmed publisher
flow cytometry; human; loading ...; fig 4c	Viau A, Bienaime F, Lukas K, Todkar A, Knoll M, Yakulov T, et al. Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney. EMBO J. 2018;37: pubmed publisher
flow cytometry; human; loading ...; fig 1a	Armas González E, Domínguez Luis M, Díaz Martín A, Arce Franco M, Castro Hernandez J, Danelon G, et al. Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis. Arthritis Res Ther. 2018;20:114 pubmed publisher
flow cytometry; human; fig 4	Sullivan A, Wang E, Farrell J, Whitaker P, Faulkner L, Peckham D, et al. ?-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells. J Allergy Clin Immunol. 2018;141:235-249.e8 pubmed publisher
flow cytometry; human; loading ...; tbl 1	Monsuur H, Weijers E, Niessen F, Gefen A, Koolwijk P, Gibbs S, et al. Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering. PLoS ONE. 2016;11:e0167056 pubmed publisher
flow cytometry; human; loading ...; fig 3a	Faivre V, Lukaszewicz A, Payen D. Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells. PLoS ONE. 2016;11:e0164489 pubmed publisher
flow cytometry; human; loading ...; fig 2b	Gadd V, Patel P, Jose S, Horsfall L, Powell E, Irvine K. Altered Peripheral Blood Monocyte Phenotype and Function in Chronic Liver Disease: Implications for Hepatic Recruitment and Systemic Inflammation. PLoS ONE. 2016;11:e0157771 pubmed publisher
	Petti L, Marlatt S, Luo Y, Scheideman E, Shelar A, DiMaio D. Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys197 and by transmembrane protein aptamers that target it for lysosomal degradation. J Biol Chem. 2018;293:8787-8801 pubmed publisher
	Sebastiani G, Ventriglia G, Stabilini A, Socci C, Morsiani C, Laurenzi A, et al. Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression. Sci Rep. 2017;7:6897 pubmed publisher
	Przybyl J, Kowalewska M, Quattrone A, Dewaele B, Vanspauwen V, Varma S, et al. Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas. JCI Insight. 2017;2: pubmed publisher
	Nieto J, Zamora C, Cantó E, Garcia Planella E, Gordillo J, Ortiz M, et al. CSF-1 regulates the function of monocytes in Crohn's disease patients in remission. Sci Rep. 2017;7:92 pubmed publisher
	Maghazachi A, Sand K, Al Jaderi Z. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity. Front Immunol. 2016;7:437 pubmed
	Williams A, José R, Mercer P, Brealey D, Parekh D, Thickett D, et al. Evidence for chemokine synergy during neutrophil migration in ARDS. Thorax. 2017;72:66-73 pubmed publisher
	Williams D, Anastos K, Morgello S, Berman J. JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individuals. J Leukoc Biol. 2015;97:401-12 pubmed publisher
	Chandrasekaran P, Moore V, Buckley M, Spurrier J, Kehrl J, Venkatesan S. HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanism. PLoS ONE. 2014;9:e86998 pubmed publisher
	Pei X, Sun Q, Zhang Y, Wang P, Peng X, Guo C, et al. PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2. J Immunol. 2014;192:1878-86 pubmed publisher
	Di Pardo A, Alberti S, Maglione V, Amico E, Cortes E, Elifani F, et al. Changes of peripheral TGF-?1 depend on monocytes-derived macrophages in Huntington disease. Mol Brain. 2013;6:55 pubmed publisher
	Manley N, Caso J, Works M, Cutler A, Zemlyak I, Sun G, et al. Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat. PLoS ONE. 2013;8:e61789 pubmed publisher
	Koenig C, Fischer Posovszky P, Rojewski M, Tews D, Schrezenmeier H, Wabitsch M, et al. Absence of CC chemokine receptors 2a and 2b from human adipose lineage cells. Mol Cell Endocrinol. 2013;369:72-85 pubmed publisher
	Duluc D, Gannevat J, Anguiano E, Zurawski S, Carley M, Boreham M, et al. Functional diversity of human vaginal APC subsets in directing T-cell responses. Mucosal Immunol. 2013;6:626-38 pubmed publisher
	Ingersoll M, Spanbroek R, Lottaz C, Gautier E, Frankenberger M, Hoffmann R, et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood. 2010;115:e10-9 pubmed publisher
	Jung D, Che Z, Kim J, Kim K, Kim K, Williams D, et al. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int J Cancer. 2010;127:332-44 pubmed publisher
	Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, et al. Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int J Cancer. 2010;126:1095-108 pubmed publisher
	Fifadara N, Aye C, Raghuwanshi S, Richardson R, Ono S. CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6. Int Immunol. 2009;21:991-1001 pubmed publisher
	Pacheco Rodriguez G, Kumaki F, Steagall W, Zhang Y, Ikeda Y, Lin J, et al. Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. J Immunol. 2009;182:1270-7 pubmed
	Hartl D, Krauss Etschmann S, Koller B, Hordijk P, Kuijpers T, Hoffmann F, et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol. 2008;181:8053-67 pubmed
	Weigt S, Elashoff R, Keane M, Strieter R, Gomperts B, Xue Y, et al. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am J Transplant. 2008;8:1512-22 pubmed publisher
	Gouwy M, Struyf S, Noppen S, Schutyser E, Springael J, Parmentier M, et al. Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events. Mol Pharmacol. 2008;74:485-95 pubmed publisher
	Burt D, Salvidio G, Tarabra E, Barutta F, Pinach S, Dentelli P, et al. The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes. Am J Pathol. 2007;171:1789-99 pubmed
	Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
	Eugenin E, Dyer G, Calderon T, Berman J. HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS. Glia. 2005;49:501-10 pubmed
	Lim H, Hillsamer P, Kim C. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest. 2004;114:1640-9 pubmed
	Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
	Perrier P, Martinez F, Locati M, Bianchi G, Nebuloni M, Vago G, et al. Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J Immunol. 2004;172:7031-42 pubmed
	Metelitsa L, Wu H, Wang H, Yang Y, Warsi Z, Asgharzadeh S, et al. Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. J Exp Med. 2004;199:1213-21 pubmed
	Nakayama E, Tanaka Y, Nagai Y, Iwamoto A, Shioda T. A CCR2-V64I polymorphism affects stability of CCR2A isoform. AIDS. 2004;18:729-38 pubmed
	Annels N, Willemze A, van der Velden V, Faaij C, van Wering E, Sie Go D, et al. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004;103:2806-8 pubmed
	Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol. 2001;166:6477-82 pubmed
	Lee B, Sharron M, Blanpain C, Doranz B, Vakili J, Setoh P, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274:9617-26 pubmed

product information

brand :

R&D Systems

master code :

MAB150

SKU :

MAB150-100

product name :

Human CCR2 Antibody

description :

The Human CCR2 Antibody from R&D Systems is a mouse monoclonal antibody to CCR2. This antibody reacts with human. The Human CCR2 Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, CyTOF-ready.

target :

CCR2

category :

Primary Antibodies

unit size :

100 ug (also 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

48607

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CCR2, Met1-Leu360, Accession # NP_001116868

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human CCR-2 transfectants but not the parental cell line or CCR-5 transfectants.

gene symbol :

CCR2

catalog number base :

MAB150

accessionNumbers :

NP_001116868

applications :

Flow Cytometry, Immunohistochemistry, CyTOF-ready

extended description :

Clone 48607 was used by HLDA to establish CD designation

2020 USD :

349

2021 USD :

369 USD

product details :

Clone 48607 was used by HLDA to establish CD designation

alt names :

C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CC-CKR-2CKR2B, CCR2, CCR-2, CCR2A, CCR2B, CD192, CD192 antigen, chemokine (C-C motif) receptor 2, CKR2, CKR2A, CMKBR2, CMKBR2MGC111760, FLJ78302, MCP-1 receptor, MCP-1-R, MCP-1-RMGC103828, MGC168006, Monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.