Human CCR1 Antibody | R&D Systems MAB145-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCR1 Antibody

catalog :

MAB145-100

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

53504

reactivity :

human, mouse

application :

western blot, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 26

Reference
Enten G, Gao X, Strzelinski H, Weche M, Liggett S, Majetschak M. α1B/D-adrenoceptors regulate chemokine receptor-mediated leukocyte migration via formation of heteromeric receptor complexes. Proc Natl Acad Sci U S A. 2022;119:e2123511119 pubmed publisher
Tian Y, Seumois G, De Oliveira Pinto L, Mateus J, Herrera de la Mata S, Kim C, et al. Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease. Cell Rep. 2019;29:4482-4495.e4 pubmed publisher
Syu G, Wang S, Ma G, Liu S, Pearce D, Prakash A, et al. Development and application of a high-content virion display human GPCR array. Nat Commun. 2019;10:1997 pubmed publisher
Fox J, Kausar F, Day A, Osborne M, Hussain K, Mueller A, et al. CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration. Sci Rep. 2018;8:9466 pubmed publisher
Vandyke K, Zeissig M, Hewett D, Martin S, Mrozik K, Cheong C, et al. HIF-2Î± Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1. Cancer Res. 2017;77:5452-5463 pubmed publisher
Kobayashi D, Endo M, Ochi H, Hojo H, Miyasaka M, Hayasaka H. Regulation of CCR7-dependent cell migration through CCR7 homodimer formation. Sci Rep. 2017;7:8536 pubmed publisher
Bellora F, Dondero A, Corrias M, Casu B, Regis S, Caliendo F, et al. Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages. J Immunol. 2017;199:1516-1525 pubmed publisher
Maghazachi A, Sand K, Al Jaderi Z. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity. Front Immunol. 2016;7:437 pubmed
Williams A, José R, Mercer P, Brealey D, Parekh D, Thickett D, et al. Evidence for chemokine synergy during neutrophil migration in ARDS. Thorax. 2017;72:66-73 pubmed publisher
Gilliland C, SALANGA C, Kawamura T, Trejo J, Handel T. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, ?-arrestin-mediated internalization. J Biol Chem. 2013;288:32194-210 pubmed publisher
Baek S, Kang S, Ra J. In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors. Exp Mol Med. 2011;43:596-603 pubmed publisher
Gouwy M, Struyf S, Berghmans N, Vanormelingen C, Schols D, Van Damme J. CXCR4 and CCR5 ligands cooperate in monocyte and lymphocyte migration and in inhibition of dual-tropic (R5/X4) HIV-1 infection. Eur J Immunol. 2011;41:963-73 pubmed publisher
Jung D, Che Z, Kim J, Kim K, Kim K, Williams D, et al. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int J Cancer. 2010;127:332-44 pubmed publisher
Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, et al. Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int J Cancer. 2010;126:1095-108 pubmed publisher
Fifadara N, Aye C, Raghuwanshi S, Richardson R, Ono S. CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6. Int Immunol. 2009;21:991-1001 pubmed publisher
Hartl D, Krauss Etschmann S, Koller B, Hordijk P, Kuijpers T, Hoffmann F, et al. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol. 2008;181:8053-67 pubmed
Weigt S, Elashoff R, Keane M, Strieter R, Gomperts B, Xue Y, et al. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am J Transplant. 2008;8:1512-22 pubmed publisher
Joubert P, Lajoie Kadoch S, Welman M, Dragon S, Létuvée S, Tolloczko B, et al. Expression and regulation of CCR1 by airway smooth muscle cells in asthma. J Immunol. 2008;180:1268-75 pubmed
Gupta S, Fuchs B, Schulz Maronde S, Heitland A, Escher S, Mack M, et al. Intravascular inactivation of CCR5 by n-Nonanoyl-CC chemokine ligand 14 and inhibition of allergic airway inflammation. J Leukoc Biol. 2008;83:765-73 pubmed
Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, et al. Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J Immunol. 2007;179:4272-82 pubmed
Ponte A, Marais E, Gallay N, Langonne A, Delorme B, Herault O, et al. The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells. 2007;25:1737-45 pubmed
Haringman J, Smeets T, Reinders Blankert P, Tak P. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis. 2006;65:294-300 pubmed
Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, et al. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur J Immunol. 2004;34:3485-96 pubmed
Annels N, Willemze A, van der Velden V, Faaij C, van Wering E, Sie Go D, et al. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004;103:2806-8 pubmed
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle M, et al. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J Leukoc Biol. 2003;73:584-90 pubmed
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol. 2001;166:6477-82 pubmed

product information

brand :

R&D Systems

master code :

MAB145

SKU :

MAB145-100

product name :

Human CCR1 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human CCR1 Antibody from R&D Systems is a mouse monoclonal antibody to CCR1. This antibody reacts with human,mouse. The Human CCR1 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.

target :

CCR1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

53504

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, CyTOF-ready

host :

Mouse

immunogen :

Swiss 3T3 mouse cell line transfected with human CCR1, Accession # P32246

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human CCR1. Reacts specifically with human CCR1 transfectants and not the parental cell line in flow cytometry. No cross-reactivity with CCR5 transfectants is observed.

gene symbol :

CCR1

accessionNumbers :

P32246

applications :

CyTOF-ready,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry

extended description :

Clone 53504 was used by HLDA to establish CD designation

USD :

469 USD

product details :

Clone 53504 was used by HLDA to establish CD designation

alt names :

C-C chemokine receptor type 1, CC-CKR-1, CCR1, CCR-1, CD191, CD191 antigen, chemokine (C-C motif) receptor 1, CKR1, CKR-1, CMKBR1SCYAR1, CMKR1, HM145C-C CKR-1, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, MIP1aR, RANTES receptor, RANTES-R

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage