product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse SSEA-4 Antibody
catalog :
MAB1435
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MC-813-70
reactivity :
human
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 66
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:1000; loading ...; fig 1b
Yamamura Y, Furuichi K, Murakawa Y, Hirabayashi S, Yoshihara M, Sako K, et al. Identification of candidate PAX2-regulated genes implicated in human kidney development. Sci Rep. 2021;11:9123 pubmed publisher
Lewis P, Silajd x17e i x107 E, Smith H, Bates N, Smith C, Mancini F, et al. A secreted proteomic footprint for stem cell pluripotency. PLoS ONE. 2024;19:e0299365 pubmed publisher
Hung T, Huang Y, Yeh C, Yeh C, Yu J, Lin C, et al. High expression of embryonic stem cell marker SSEA3 confers poor prognosis and promotes epithelial mesenchymal transition in hepatocellular carcinoma. Biomed J. 2023;47:100612 pubmed publisher
Isono W, Kawasaki T, Ichida J, Nagasaka K, Hiraike O, Umezawa A, et al. Transcriptomic analysis of feeder-free culture system for maintaining naïve-state pluripotency in human pluripotent stem cells. Stem Cell Investig. 2023;10:10 pubmed publisher
Shigyo M, Kobayashi Y, Platoshyn O, Marsala S, Kato T, Takamura N, et al. Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization. Cell Transplant. 2023;32:9636897231163232 pubmed publisher
Aguirre V xe1 zquez A, Castorena Torres F, Silva Ram xed rez B, Pe xf1 uelas Urquides K, Camacho Moll M, Salazar Olivo L, et al. Cell-type dependent regulation of pluripotency and chromatin remodeling genes by hydralazine. Stem Cell Res Ther. 2023;14:42 pubmed publisher
Cadenas Martin M, Arnalich Montiel F, Miguel M. Derivation of Limbal Stem Cells from Human Adult Mesenchymal Stem Cells for the Treatment of Limbal Stem Cell Deficiency. Int J Mol Sci. 2023;24: pubmed publisher
Lotila J, Hyv xe4 rinen T, Skottman H, Airas L, Narkilahti S, Hagman S. Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient. Stem Cell Res. 2022;63:102865 pubmed publisher
Naidu P, Denham E, Bartlett C, McGonigle T, Taylor N, Norret M, et al. Protein corona formation moderates the release kinetics of ion channel antagonists from transferrin-functionalized polymeric nanoparticles. RSC Adv. 2020;10:2856-2869 pubmed publisher
Rodina N, Khudiakov A, Perepelina K, Muravyev A, Boytsov A, Zlotina A, et al. Generation of iPSC line (FAMRCi009-A) from patient with familial progressive cardiac conduction disorder carrying genetic variant FLNC p.Val2264Met. Stem Cell Res. 2021;59:102640 pubmed publisher
Perepelina K, Khudiakov A, Rodina N, Boytsov A, Vavilova T, Zlotina A, et al. Generation of iPSC line FAMRCi010-A from patient with restrictive cardiomyopathy carrying genetic variant FLNC p.Gly2011Arg. Stem Cell Res. 2021;59:102639 pubmed publisher
Lee M, Stebbins M, Jiao H, Huang H, Leiferman E, Walczak B, et al. Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration. Sci Adv. 2021;7: pubmed publisher
Lee H, Lee H, Na C, Song I, Ryu J, Park J. Evaluation of the Age- and Sex-Related Changes of the Osteogenic Differentiation Potentials of Healthy Bone Marrow-Derived Mesenchymal Stem Cells. Medicina (Kaunas). 2021;57: pubmed publisher
Penev A, Bazley A, Shen M, Boeke J, Savage S, Sfeir A. Alternative splicing is a developmental switch for hTERT expression. Mol Cell. 2021;81:2349-2360.e6 pubmed publisher
Isono W, Kawasaki T, Ichida J, Ayabe T, Hiraike O, Umezawa A, et al. The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naïve-state pluripotency in non-hypoxic conditions. Regen Ther. 2020;15:161-168 pubmed publisher
Bellák T, Fekécs Z, Török D, Tancos Z, Nemes C, Tézsla Z, et al. Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment. Sci Rep. 2020;10:22414 pubmed publisher
Perepelina K, Kostina A, Klauzen P, Khudiakov A, Rabino M, Crasto S, et al. Generation of two iPSC lines (FAMRCi007-A and FAMRCi007-B) from patient with Emery-Dreifuss muscular dystrophy and heart rhythm abnormalities carrying genetic variant LMNA p.Arg249Gln. Stem Cell Res. 2020;47:101895 pubmed publisher
Klauzen P, Perepelina K, Khudiakov A, Zlotina A, Fomicheva Y, Pervunina T, et al. Generation of two induced pluripotent stem cell lines (FAMRCi005-A and FAMRCi005-B) from patient carrying genetic variant LMNA p.Asp357Val. Stem Cell Res. 2020;43:101719 pubmed publisher
Khudiakov A, Perepelina K, Klauzen P, Zlotina A, Gusev K, Kaznacheyeva E, et al. Generation of two iPSC lines (FAMRCi004-A and FAMRCi004-B) from patient with familial progressive cardiac conduction disorder carrying genetic variant DSP p.His1684Arg. Stem Cell Res. 2020;43:101720 pubmed publisher
Perepelina K, Klauzen P, Khudiakov A, Zlotina A, Fomicheva Y, Rudenko D, et al. Generation of two iPSC lines (FAMRCi006-A and FAMRCi006-B) from patient with dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy associated with genetic variant LMNAp.Arg527Pro. Stem Cell Res. 2020;43:101714 pubmed publisher
Toomey L, Bartlett C, Gavriel N, McGonigle T, Majimbi M, Gopalasingam G, et al. Comparing modes of delivery of a combination of ion channel inhibitors for limiting secondary degeneration following partial optic nerve transection. Sci Rep. 2019;9:15297 pubmed publisher
Woods S, Bates N, Dunn S, Serracino Inglott F, Hardingham T, Kimber S. Generation of Human-Induced Pluripotent Stem Cells From Anterior Cruciate Ligament. J Orthop Res. 2020;38:92-104 pubmed publisher
Nambiar T, Billon P, Diedenhofen G, Hayward S, Taglialatela A, Cai K, et al. Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant. Nat Commun. 2019;10:3395 pubmed publisher
Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam C, Garg P, et al. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019;572:335-340 pubmed publisher
Ichisima J, Suzuki N, Samata B, Awaya T, Takahashi J, Hagiwara M, et al. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. J Hum Genet. 2019;64:445-458 pubmed publisher
Wang L, De Solis A, Goffer Y, Birkenbach K, Engle S, Tanis R, et al. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019;4: pubmed publisher
Jeon H, Kim J, Choi J, Han E, Song C, Lee J, et al. Effects of the Extracts from Fruit and Stem of Camellia japonica on Induced Pluripotency and Wound Healing. J Clin Med. 2018;7: pubmed publisher
Kaur S, Abu Shahba A, Paananen R, Hongisto H, Hiidenmaa H, Skottman H, et al. Small non-coding RNA landscape of extracellular vesicles from human stem cells. Sci Rep. 2018;8:15503 pubmed publisher
Stratigopoulos G, De Rosa M, LeDuc C, Leibel R, Doege C. DMSO increases efficiency of genome editing at two non-coding loci. PLoS ONE. 2018;13:e0198637 pubmed publisher
Khudiakov A, Kostina D, Zlotina A, Nikulina T, Sergushichev A, Gudkova A, et al. Generation of iPSC line from desmin-related cardiomyopathy patient carrying splice site mutation of DES gene. Stem Cell Res. 2017;24:77-80 pubmed publisher
Kuo H, Lin R, Hung J, Hsieh C, Hung T, Lo F, et al. High expression FUT1 and B3GALT5 is an independent predictor of postoperative recurrence and survival in hepatocellular carcinoma. Sci Rep. 2017;7:10750 pubmed publisher
Kooreman N, de Almeida P, Stack J, Nelakanti R, Diecke S, Shao N, et al. Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep. 2017;20:1978-1990 pubmed publisher
Pao S, Chien K, Lin H, Tai M, Chen J, Liang C. Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts. J Chin Med Assoc. 2017;80:595-607 pubmed publisher
Collier A, Panula S, Schell J, Chovanec P, Plaza Reyes A, Petropoulos S, et al. Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States. Cell Stem Cell. 2017;20:874-890.e7 pubmed publisher
De Sousa P, Steeg R, Wachter E, Bruce K, King J, Hoeve M, et al. Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience. Stem Cell Res. 2017;20:105-114 pubmed publisher
Karakikes I, Termglinchan V, Cepeda D, Lee J, Diecke S, Hendel A, et al. A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Circ Res. 2017;120:1561-1571 pubmed publisher
Hu L, Du L, Zhao Y, Li W, Ouyang Q, Zhou D, et al. Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression. Stem Cell Res. 2017;20:14-20 pubmed publisher
Ranghino A, Bruno S, Bussolati B, Moggio A, Dimuccio V, Tapparo M, et al. The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury. Stem Cell Res Ther. 2017;8:24 pubmed publisher
Freyer N, Knöspel F, Strahl N, Amini L, Schrade P, Bachmann S, et al. Hepatic Differentiation of Human Induced Pluripotent Stem Cells in a Perfused Three-Dimensional Multicompartment Bioreactor. Biores Open Access. 2016;5:235-48 pubmed publisher
Son M, Lee M, Jeon H, Seol B, Kim J, Chang J, et al. Generation and characterization of integration-free induced pluripotent stem cells from patients with autoimmune disease. Exp Mol Med. 2016;48:e232 pubmed publisher
Guillevic O, Ferratge S, Pascaud J, Driancourt C, Boyer Di Ponio J, Uzan G. A Novel Molecular and Functional Stemness Signature Assessing Human Cord Blood-Derived Endothelial Progenitor Cell Immaturity. PLoS ONE. 2016;11:e0152993 pubmed publisher
Katayama M, Hirayama T, Horie K, Kiyono T, Donai K, Takeda S, et al. Induced Pluripotent Stem Cells With Six Reprogramming Factors From Prairie Vole, Which Is an Animal Model for Social Behaviors. Cell Transplant. 2016;25:783-96 pubmed publisher
Sidney L, Branch M, Dua H, Hopkinson A. Effect of culture medium on propagation and phenotype of corneal stroma-derived stem cells. Cytotherapy. 2015;17:1706-22 pubmed publisher
Imberti B, Corna D, Rizzo P, Xinaris C, Abbate M, Longaretti L, et al. Renal primordia activate kidney regenerative events in a rat model of progressive renal disease. PLoS ONE. 2015;10:e0120235 pubmed publisher
Jung J, Lee S, Kim J, Lee S, Sung H, An J, et al. CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev. 2015;24:948-61 pubmed publisher
Luo L, Kawakatsu M, Guo C, Urata Y, Huang W, Ali H, et al. Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells. Sci Rep. 2014;4:3779 pubmed publisher
Sproul A, Jacob S, Prè D, Kim S, Nestor M, Navarro Sobrino M, et al. Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. PLoS ONE. 2014;9:e84547 pubmed publisher
Zeng S, Liu L, Sun Y, Xie P, Hu L, Yuan D, et al. Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells. J Cell Sci. 2014;127:752-62 pubmed publisher
Myers F, Silver J, Zhuge Y, Beygui R, Zarins C, Lee L, et al. Robust pluripotent stem cell expansion and cardiomyocyte differentiation via geometric patterning. Integr Biol (Camb). 2013;5:1495-506 pubmed publisher
Hayashi R, Ishikawa Y, Ito M, Kageyama T, Takashiba K, Fujioka T, et al. Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium. PLoS ONE. 2012;7:e45435 pubmed publisher
Takemitsu H, Zhao D, Yamamoto I, Harada Y, Michishita M, Arai T. Comparison of bone marrow and adipose tissue-derived canine mesenchymal stem cells. BMC Vet Res. 2012;8:150 pubmed publisher
Shimojima K, Inoue T, Imai Y, Arai Y, Komoike Y, Sugawara M, et al. Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus-Merzbacher disease patient with a partial PLP1 duplication. J Hum Genet. 2012;57:580-6 pubmed publisher
Vaculik C, Schuster C, Bauer W, Iram N, Pfisterer K, Kramer G, et al. Human dermis harbors distinct mesenchymal stromal cell subsets. J Invest Dermatol. 2012;132:563-74 pubmed publisher
Kim S, Kim M, Jung H, Kim W, Kwon S, Son M, et al. Comparative proteomic analysis of human somatic cells, induced pluripotent stem cells, and embryonic stem cells. Stem Cells Dev. 2012;21:1272-86 pubmed publisher
Emdad L, D Souza S, Kothari H, Qadeer Z, Germano I. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem Cells Dev. 2012;21:404-10 pubmed publisher
Muller F, Schuldt B, Williams R, Mason D, Altun G, Papapetrou E, et al. A bioinformatic assay for pluripotency in human cells. Nat Methods. 2011;8:315-7 pubmed publisher
Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, Kalomoiris S, et al. Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells. Mol Ther. 2011;19:584-93 pubmed publisher
Orban T, Apáti A, Nemeth A, Varga N, Krízsik V, Schamberger A, et al. Applying a "double-feature" promoter to identify cardiomyocytes differentiated from human embryonic stem cells following transposon-based gene delivery. Stem Cells. 2009;27:1077-87 pubmed publisher
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Gil J, Woo D, Shim J, Kim S, You H, Park S, et al. Vitronectin promotes oligodendrocyte differentiation during neurogenesis of human embryonic stem cells. FEBS Lett. 2009;583:561-7 pubmed publisher
Fong H, Hohenstein K, Donovan P. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells. 2008;26:1931-8 pubmed publisher
Hohenstein K, Pyle A, Chern J, Lock L, Donovan P. Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells. Stem Cells. 2008;26:1436-43 pubmed publisher
Reed S, Johnson S. Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types. J Cell Physiol. 2008;215:329-36 pubmed
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Josephson R, Ording C, Liu Y, Shin S, Lakshmipathy U, Toumadje A, et al. Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. Stem Cells. 2007;25:437-46 pubmed
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product information
brand :
R&D Systems
master code :
MAB1435
SKU :
MAB1435
product name :
Human/Mouse SSEA-4 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human/Mouse SSEA-4 Antibody from R&D Systems is a mouse monoclonal antibody to SSEA-4. This antibody reacts with canine,equine,feline,human,mouse,primate - macaca mulatta (rhesus macaque). The Human/Mouse SSEA-4 Antibody has been validated for the following applications: Immunocytochemistry,IF/ICC,Differentiation,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen.
target :
SSEA-4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in MES with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
MC-813-70
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 8-25 ug/mL
host :
Mouse
immunogen :
2120Ep human embryonal carcinoma cell line
isotype :
IgG3
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Canine,Equine,Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque)
specificity :
Recognizes a carbohydrate epitope of SSEA-4 (1, 2).
top caption :
Detection of SSEA-4 antibody in NTera-2 Human Cell Line antibody by Flow Cytometry.
applications :
IF/ICC,Differentiation,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
489 USD
alt names :
SSEA4, SSEA-4;stage-specific embryonic antigen 4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.