product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human SOST/Sclerostin Antibody
catalog :
MAB1406-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
220902
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 14
Reference
Kurgan N, Baranowski B, Stoikos J, MacNeil A, Fajardo V, Macpherson R, et al. Characterization of sclerostin's response within white adipose tissue to an obesogenic diet at rest and in response to acute exercise in male mice. Front Physiol. 2022;13:1061715 pubmed publisher
Kuna V, Lundgren A, Anerillas L, Kelk P, Brohlin M, Wiberg M, et al. Efficacy of Nerve-Derived Hydrogels to Promote Axon Regeneration Is Influenced by the Method of Tissue Decellularization. Int J Mol Sci. 2022;23: pubmed publisher
Kurgan N, Islam H, Matusiak J, Baranowski B, Stoikos J, Fajardo V, et al. Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4-weeks of sprint interval training in young men with obesity. Physiol Rep. 2022;10:e15232 pubmed publisher
Wei Q, Wang B, Hu H, Xie C, Ling L, Gao J, et al. Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression. Int J Mol Med. 2020;45:816-824 pubmed publisher
Stapledon C, Tsangari H, Solomon L, Campbell D, Hurtado P, Krishnan R, et al. Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis. PLoS ONE. 2019;14:e0222602 pubmed publisher
Inagaki Y, Hookway E, Kashima T, Munemoto M, Tanaka Y, Hassan A, et al. Sclerostin expression in bone tumours and tumour-like lesions. Histopathology. 2016;69:470-8 pubmed publisher
Pereira R, Valta H, Tumber N, Salusky I, Jalanko H, Mäkitie O, et al. Altered Osteocyte-Specific Protein Expression in Bone after Childhood Solid Organ Transplantation. PLoS ONE. 2015;10:e0138156 pubmed publisher
Folestad A, Ålund M, Asteberg S, Fowelin J, Aurell Y, Göthlin J, et al. Role of Wnt/β-catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients. Acta Orthop. 2015;86:415-25 pubmed publisher
Pereira R, Juppner H, Gales B, Salusky I, Wesseling Perry K. Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients. PLoS ONE. 2015;10:e0120856 pubmed publisher
Cejka D, Herberth J, Branscum A, Fardo D, Monier Faugere M, Diarra D, et al. Sclerostin and Dickkopf-1 in renal osteodystrophy. Clin J Am Soc Nephrol. 2011;6:877-82 pubmed publisher
Jilka R, O Brien C, Bartell S, Weinstein R, Manolagas S. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J Bone Miner Res. 2010;25:2427-37 pubmed publisher
Mödder U, Clowes J, Hoey K, Peterson J, McCready L, Oursler M, et al. Regulation of circulating sclerostin levels by sex steroids in women and in men. J Bone Miner Res. 2011;26:27-34 pubmed publisher
Appel H, Ruiz Heiland G, Listing J, Zwerina J, Herrmann M, Mueller R, et al. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum. 2009;60:3257-62 pubmed publisher
Jager A, Gotz W, Lossdörfer S, Rath Deschner B. Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro. J Periodontal Res. 2010;45:246-54 pubmed publisher
product information
master code :
MAB1406
SKU :
MAB1406-100
product name :
Human SOST/Sclerostin Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human SOST/Sclerostin Antibody from R&D Systems is a mouse monoclonal antibody to SOST/Sclerostin. This antibody reacts with human,mouse. The Human SOST/Sclerostin Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,ELISA Development,Immunohistochemistry,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair).
target :
SOST/Sclerostin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
220902
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human SOST/Sclerostin, Gln24-Tyr213, Accession # Q9BQB4
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human SOST/Sclerostin in ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse SOST is observed.
gene symbol :
SOST
accessionNumbers :
Q9BQB4
applications :
Western Blot,Immunocytochemistry,ELISA Development,Immunohistochemistry,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair)
USD :
469 USD
alt names :
sclerostin, VBCHsclerosteosis
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.