Human B7-1/CD80 Antibody | R&D Systems MAB140-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human B7-1/CD80 Antibody

catalog :

MAB140-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

37711

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 26

Reference
Yang L, Han Y, Zhang T, Dong X, Ge J, Roy A, et al. Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection. bioRxiv. 2024;: pubmed publisher
Ko K, Kim G, Sung H, Park W, Lee K. Potential Role of Macrophage Polarization in the Progression of Hunner-Type Interstitial Cystitis. Int J Mol Sci. 2024;25: pubmed publisher
Nielsen M, B xe6 k R, Jorgensen M, Mellergaard M, Handberg A. Increased extracellular vesicles (EVs) related to T cell-mediated inflammation and vascular function in familial hypercholesterolemia. Atheroscler Plus. 2023;53:16-25 pubmed publisher
Shankar S, Stolp J, Juvet S, Beckett J, Macklin P, Issa F, et al. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022;13:3121 pubmed publisher
Pham T, Spaulding C, Shields M, Metropulos A, Shah D, Khalafalla M, et al. Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity. JCI Insight. 2022;7: pubmed publisher
Yamada T, Miki Y, Suzuki M, Kondoh O, Saito Koyama R, Ono K, et al. B7-1 and programmed cell death-ligand 1 in primary and lymph node metastasis lesions of non-small cell lung carcinoma. Cancer Med. 2022;11:479-491 pubmed publisher
Sudo G, Aoki H, Yamamoto E, Takasawa A, Niinuma T, Yoshido A, et al. Activated macrophages promote invasion by early colorectal cancer via an interleukin 1β-serum amyloid A1 axis. Cancer Sci. 2021;112:4151-4165 pubmed publisher
Liu Y, He S, Wang X, Peng W, Chen Q, Chi D, et al. Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution. Nat Commun. 2021;12:741 pubmed publisher
Diskin B, Adam S, Cassini M, Sanchez G, Liria M, Aykut B, et al. PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer. Nat Immunol. 2020;21:442-454 pubmed publisher
Scarpa M, Fassan M, Kotsafti A, Realdon S, Dall Olmo L, Morbin T, et al. CD80 expression promotes immune surveillance in Barrett's metaplasia. Oncoimmunology. 2019;8:e1636618 pubmed publisher
Fassan M, Cavallin F, Guzzardo V, Kotsafti A, Scarpa M, Cagol M, et al. PD-L1 expression, CD8+ and CD4+ lymphocyte rate are predictive of pathological complete response after neoadjuvant chemoradiotherapy for squamous cell cancer of the thoracic esophagus. Cancer Med. 2019;8:6036-6048 pubmed publisher
Kleinpeter P, Remy Ziller C, Winter E, Gantzer M, Nourtier V, Kempf J, et al. By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1. J Virol. 2019;93: pubmed publisher
Gill N, Leng Y, Romero R, Xu Y, Panaitescu B, Miller D, et al. The immunophenotype of decidual macrophages in acute atherosis. Am J Reprod Immunol. 2019;81:e13098 pubmed publisher
Minamikawa S, Nozu K, Maeta S, Yamamura T, Nakanishi K, Fujimura J, et al. The utility of urinary CD80 as a diagnostic marker in patients with renal diseases. Sci Rep. 2018;8:17322 pubmed publisher
Zhang M, Nakamura K, Kageyama S, Lawal A, Gong K, Bhetraratana M, et al. Myeloid HO-1 modulates macrophage polarization and protects against ischemia-reperfusion injury. JCI Insight. 2018;3: pubmed publisher
Li J, Xu S, Zhao Y, Yu S, Ge L, Xu B. Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord. Mol Med Rep. 2018;18:4969-4977 pubmed publisher
Shiba M, Sugano Y, Ikeda Y, Okada H, Nagai T, Ishibashi Ueda H, et al. Presence of increased inflammatory infiltrates accompanied by activated dendritic cells in the left atrium in rheumatic heart disease. PLoS ONE. 2018;13:e0203756 pubmed publisher
He S, Wu C, Xiao J, Li D, Sun Z, Li M. Endothelial extracellular vesicles modulate the macrophage phenotype: Potential implications in atherosclerosis. Scand J Immunol. 2018;87:e12648 pubmed publisher
Lee S, Baek S, Paik J, Kim S, Na K, Chae D, et al. Tubular B7-1 expression parallels proteinuria levels, but not clinical outcomes in adult minimal change disease patients. Sci Rep. 2017;7:41859 pubmed publisher
Luo X, Liu X, Tang J, Yang W, Ni Z, Chen Q, et al. Autoantibodies against CD80 in patients with COPD. Clin Transl Immunology. 2016;5:e103 pubmed
Gagliardini E, Novelli R, Corna D, Zoja C, Ruggiero B, Benigni A, et al. B7-1 Is Not Induced in Podocytes of Human and Experimental Diabetic Nephropathy. J Am Soc Nephrol. 2016;27:999-1005 pubmed publisher
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, et al. Tumor-activated TCR??? T cells from gastric cancer patients induce the antitumor immune response of TCR??? T cells via their antigen-presenting cell-like effects. J Immunol Res. 2014;2014:593562 pubmed publisher
Bullers S, Baker S, Ingham E, Southgate J. The human tissue-biomaterial interface: a role for PPAR?-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A. 2014;20:2390-401 pubmed publisher
Ribot J, deBarros A, Mancio Silva L, Pamplona A, Silva Santos B. B7-CD28 costimulatory signals control the survival and proliferation of murine and human ?? T cells via IL-2 production. J Immunol. 2012;189:1202-8 pubmed publisher
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product information

master code :

MAB140

SKU :

MAB140-100

product name :

Human B7-1/CD80 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human B7-1/CD80 Antibody from R&D Systems is a mouse monoclonal antibody to B7-1/CD80. This antibody reacts with human,mouse. The Human B7-1/CD80 Antibody has been validated for the following applications: Immunohistochemistry,ELISA Development (Detection),T Cell Activation,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Dual RNAscope ISH-IHC Compatible.

target :

B7-1/CD80

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

37711

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human B7-1/CD80, Val35-Asn242 (predicted), Accession # P33681

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human B7-1/CD80 in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant human (rh) B7-2, recombinant mouse (rm) B7-1, rmB7-2, rhB7-H1, rhB7-H2, rhB7-H3 or rmPD-L2 is observed.

gene symbol :

CD80

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

Antibody validation :

Orthogonal Validation

top caption :

Detection of B7-1/CD80 antibody in Raji Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

P33681

applications :

Immunohistochemistry,ELISA Development (Detection),T Cell Activation,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Dual RNAscope ISH-IHC Compatible

USD :

479 USD

alt names :

Activation B7-1 antigen, B7, B71, BB1, CD28LG1, CD28LGB7-1 antigen), CD80, CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage