product summary
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company name :
R&D Systems
product type :
antibody
product name :
NKG2C/CD159c Antibody
catalog :
MAB1381-100
quantity :
100 ug (also 25 ug)
price :
453 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
134522
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 14
Reference
Maeda Y, Wada H, Sugiyama D, Saito T, Irie T, Itahashi K, et al. Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab. Nat Commun. 2021;12:7280 pubmed publisher
Sottile R, Panjwani M, Lau C, Daniyan A, Tanaka K, Barker J, et al. Human cytomegalovirus expands a CD8+ T cell population with loss of BCL11B expression and gain of NK cell identity. Sci Immunol. 2021;6:eabe6968 pubmed publisher
H xf2 G, Celik A, Huyton T, Hiemisch W, Blasczyk R, Simper G, et al. NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain. Int J Mol Sci. 2020;21: pubmed publisher
Pump W, Kraemer T, Huyton T, Hò G, Blasczyk R, Bade Doeding C. Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8⁺ T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia. Int J Mol Sci. 2019;20: pubmed publisher
Ye W, Chew M, Hou J, Lai F, Leopold S, Loo H, et al. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. PLoS Pathog. 2018;14:e1007298 pubmed publisher
Chiu C, Sánchez San Martín C, Bouquet J, Li T, Yagi S, Tamhankar M, et al. Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection. Sci Rep. 2017;7:17126 pubmed publisher
Lougaris V, Patrizi O, Baronio M, Tabellini G, Tampella G, Damiati E, et al. NFKB1 regulates human NK cell maturation and effector functions. Clin Immunol. 2017;175:99-108 pubmed publisher
Redondo Pachón D, Crespo M, Yelamos J, Muntasell A, Pérez Sáez M, Pérez Fernández S, et al. Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients. J Immunol. 2017;198:94-101 pubmed
Antón O, Vielkind S, Peterson M, Tagaya Y, Long E. NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors. J Immunol. 2015;195:4810-21 pubmed publisher
Horowitz A, Guethlein L, Nemat Gorgani N, Norman P, Cooley S, Miller J, et al. Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation. J Immunol. 2015;195:4524-36 pubmed publisher
Costa García M, Vera A, Moraru M, Vilches C, López Botet M, Muntasell A. Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus. J Immunol. 2015;194:2715-24 pubmed publisher
Heatley S, Pietra G, Lin J, Widjaja J, Harpur C, Lester S, et al. Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells. J Biol Chem. 2013;288:8679-90 pubmed publisher
Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, et al. Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components. Blood. 2008;111:3155-62 pubmed publisher
Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou J, Charreau B. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood. 2007;109:2806-14 pubmed
image
image 1 :
R&D Systems MAB1381-100 image 1
Detection of NKG2C/CD159c antibody in Human Blood Lymphocytes antibody by Flow Cytometry.
product information
brand :
R&D Systems
master code :
MAB1381
SKU :
MAB1381-100
product name :
NKG2C/CD159c Antibody
description :
The Human NKG2C/CD159c Antibody from R&D Systems is a mouse monoclonal antibody to NKG2C/CD159c/KLRC2. This antibody reacts with human. The Human NKG2C/CD159c Antibody has been validated for the following applications: Flow Cytometry, CyTOF-reported.
target :
NKG2C/CD159c
category :
Primary Antibodies
sizes available :
100 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
134522
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human NKG2C/CD159c
gene symbol :
KLRC2
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
applications :
Flow Cytometry, CyTOF-reported
USD :
453 USD
alt names :
CD159 antigen-like family member C, CD159c, CD159c antigen, killer cell lectin-like receptor subfamily C, member 2, KLRC2, MGC138244, NK cell receptor C, NKG2-C, NKG2-C type II integral membrane protein, NKG2CNKG2-C-activating NK receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.