product summary
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company name :
R&D Systems
product type :
antibody
product name :
Oligodendrocyte Marker O4 Antibody
catalog :
MAB1326
quantity :
50 ug
price :
313 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
O4
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry
more info or order :
citations: 69
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; 1:500; fig 4g
Ichinose M, Suzuki N, Wang T, Kobayashi H, Vrbanac L, Ng J, et al. The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses. Development. 2021;148: pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 5c
Seol B, Kim Y, Cho Y. Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells. Int J Mol Sci. 2021;22: pubmed publisher
Mathews J, Kuchling F, Baez Nieto D, Diberardinis M, Pan J, Levin M. Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma. Cancers (Basel). 2022;14: pubmed publisher
Nölle A, van Dijken I, Waelti C, Calini D, Bryois J, Lezan E, et al. Enrichment of Glial Cells From Human Post-mortem Tissue for Transcriptome and Proteome Analysis Using Immunopanning. Front Cell Neurosci. 2021;15:772011 pubmed publisher
Park W, Yeon G, Yu M, Goo H, Hwang S, Na D, et al. A Novel Vitronectin Peptide Facilitates Differentiation of Oligodendrocytes from Human Pluripotent Stem Cells (Synthetic ECM for Oligodendrocyte Differentiation). Biology (Basel). 2021;10: pubmed publisher
Chesnut M, Paschoud H, Repond C, Smirnova L, Hartung T, Zurich M, et al. Human IPSC-Derived Model to Study Myelin Disruption. Int J Mol Sci. 2021;22: pubmed publisher
Shimizu T, Murakoshi H, Matsumoto H, Ichino K, Hattori A, Ueno S, et al. Tension Sensor Based on Fluorescence Resonance Energy Transfer Reveals Fiber Diameter-Dependent Mechanical Factors During Myelination. Front Cell Neurosci. 2021;15:685044 pubmed publisher
Manousi A, Göttle P, Reiche L, Cui Q, Healy L, Akkermann R, et al. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. EBioMedicine. 2021;65:103276 pubmed publisher
Lindborg J, Tran N, Chenette D, DeLuca K, Foli Y, Kannan R, et al. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Rep. 2021;34:108777 pubmed publisher
Fujii Tezuka R, Ishige Wada M, Nagoshi N, Okano H, Mugishima H, Takahashi S, et al. Umbilical artery tissue contains p75 neurotrophin receptor-positive pericyte-like cells that possess neurosphere formation capacity and neurogenic differentiation potential. Regen Ther. 2021;16:1-11 pubmed publisher
Yazdankhah M, Ghosh S, Shang P, Stepicheva N, Hose S, Liu H, et al. BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes. Autophagy. 2021;:1-20 pubmed publisher
Al Bakri Z, Ishige Wada M, Fukuda N, Yoshida Noro C, Nagoshi N, Okano H, et al. Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood. Regen Ther. 2020;15:53-63 pubmed publisher
Kleszka K, Leu T, Quinting T, Jastrow H, Pechlivanis S, Fandrey J, et al. Hypoxia-inducible factor-2α is crucial for proper brain development. Sci Rep. 2020;10:19146 pubmed publisher
García León J, García Diaz B, Eggermont K, Cáceres Palomo L, Neyrinck K, Madeiro da Costa R, et al. Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. Nat Protoc. 2020;15:3716-3744 pubmed publisher
Hoshino T, Yamakado H, Takahashi R, Matsuzawa S. Susceptibility to erastin-induced ferroptosis decreases during maturation in a human oligodendrocyte cell line. FEBS Open Bio. 2020;10:1758-1764 pubmed publisher
Micali N, Kim S, Diaz Bustamante M, Stein O Brien G, Seo S, Shin J, et al. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Rep. 2020;31:107599 pubmed publisher
Wedel M, Fröb F, Elsesser O, Wittmann M, Lie D, Reis A, et al. Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res. 2020;48:4839-4857 pubmed publisher
Furube E, Ishii H, Nambu Y, Kurganov E, Nagaoka S, Morita M, et al. Neural stem cell phenotype of tanycyte-like ependymal cells in the circumventricular organs and central canal of adult mouse brain. Sci Rep. 2020;10:2826 pubmed publisher
Thümmler K, Rom E, Zeis T, Lindner M, Brunner S, Cole J, et al. Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential. Acta Neuropathol Commun. 2019;7:212 pubmed publisher
Piatek P, Namiecinska M, Domowicz M, Przygodzka P, Wieczorek M, Michlewska S, et al. MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration. Cells. 2019;8: pubmed publisher
Neumann B, Baror R, Zhao C, SEGEL M, Dietmann S, Rawji K, et al. Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells. Cell Stem Cell. 2019;25:473-485.e8 pubmed publisher
Baba N, Wang F, Iizuka M, Shen Y, Yamashita T, Takaishi K, et al. Induction of regional chemokine expression in response to human umbilical cord blood cell infusion in the neonatal mouse ischemia-reperfusion brain injury model. PLoS ONE. 2019;14:e0221111 pubmed publisher
Bernstock J, Peruzzotti Jametti L, Leonardi T, Vicario N, Ye D, Lee Y, et al. SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke. EBioMedicine. 2019;42:214-224 pubmed publisher
Marton R, Miura Y, Sloan S, Li Q, Revah O, Levy R, et al. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures. Nat Neurosci. 2019;22:484-491 pubmed publisher
Yu X, Cheng G, Zhang L, Zhang Y, Wang Q, Zhao M, et al. N-Phenylquinazolin-2-amine Yhhu4952 as a novel promotor for oligodendrocyte differentiation and myelination. Sci Rep. 2018;8:14040 pubmed publisher
Latchoumane C, Jackson L, Sendi M, Tehrani K, Mortensen L, Stice S, et al. Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro. Sci Rep. 2018;8:10957 pubmed publisher
Le O, Palacio L, Bernier G, Batinic Haberle I, Hickson G, Beausejour C. INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice. Stem Cell Reports. 2018;10:1721-1733 pubmed publisher
Yang C, Li X, Wu Y, Shen Q, Zeng Y, Xiong Q, et al. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nat Commun. 2018;9:838 pubmed publisher
Guo Y, Suo N, Cui X, Yuan Q, Xie X. Vitamin C promotes oligodendrocytes generation and remyelination. Glia. 2018;66:1302-1316 pubmed publisher
Zhang H, Fang X, Huang D, Luo Q, Zheng M, Wang K, et al. Erythropoietin signaling increases neurogenesis and oligodendrogenesis of endogenous neural stem cells following spinal cord injury both in vivo and in vitro. Mol Med Rep. 2017;: pubmed publisher
Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
Lee J, Laronde S, Collins T, Shapovalova Z, Tanasijevic B, McNicol J, et al. Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency. Cell Rep. 2017;19:20-35 pubmed publisher
Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein P, Heuer H, et al. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Sci Rep. 2017;7:44861 pubmed publisher
Plemel J, Caprariello A, Keough M, Henry T, Tsutsui S, Chu T, et al. Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis. J Cell Biol. 2017;216:1163-1181 pubmed publisher
Yamashita T, Miyamoto Y, Bando Y, Ono T, Kobayashi S, Doi A, et al. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells. PLoS ONE. 2017;12:e0171947 pubmed publisher
Leiss L, Mutlu E, Øyan A, Yan T, Tsinkalovsky O, Sleire L, et al. Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts. BMC Cancer. 2017;17:108 pubmed publisher
Cha M, Kwon Y, Ahn H, Jeong H, Lee Y, Moon M, et al. Protein-Induced Pluripotent Stem Cells Ameliorate Cognitive Dysfunction and Reduce Aβ Deposition in a Mouse Model of Alzheimer's Disease. Stem Cells Transl Med. 2017;6:293-305 pubmed publisher
Konířová J, Oltová J, Corlett A, Kopycinska J, Kolar M, Bartunek P, et al. Modulated DISP3/PTCHD2 expression influences neural stem cell fate decisions. Sci Rep. 2017;7:41597 pubmed publisher
Liu Y, HARLOW D, Given K, Owens G, Macklin W, Bennett J. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016;13:301 pubmed
Zhu H, Zhao Y, Wu H, Jiang N, Wang Z, Lin W, et al. Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. Sci Rep. 2016;6:38108 pubmed publisher
Shingu T, Ho A, Yuan L, Zhou X, Dai C, Zheng S, et al. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017;49:75-86 pubmed publisher
Xu W, Sachewsky N, Azimi A, Hung M, Gappasov A, Morshead C. Myelin Basic Protein Regulates Primitive and Definitive Neural Stem Cell Proliferation from the Adult Spinal Cord. Stem Cells. 2017;35:485-496 pubmed publisher
Arulmoli J, Pathak M, McDonnell L, Nourse J, Tombola F, Earthman J, et al. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Sci Rep. 2015;5:8499 pubmed publisher
Leite C, Silva N, Mendes S, Ribeiro A, de Faria J, Lourenço T, et al. Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage. PLoS ONE. 2014;9:e111059 pubmed publisher
Hu S, Rotschafer J, Lokensgard J, Cheeran M. Activated CD8+ T lymphocytes inhibit neural stem/progenitor cell proliferation: role of interferon-gamma. PLoS ONE. 2014;9:e105219 pubmed publisher
Herrmann A, Cherryholmes G, Schroeder A, Phallen J, Alizadeh D, Xin H, et al. TLR9 is critical for glioma stem cell maintenance and targeting. Cancer Res. 2014;74:5218-28 pubmed publisher
Skardelly M, Hempel E, Hirrlinger J, Wegner F, Meixensberger J, Milosevic J. Fluorescent protein-expressing neural progenitor cells as a tool for transplantation studies. PLoS ONE. 2014;9:e99819 pubmed publisher
Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells. 2014;32:2178-87 pubmed publisher
Wang T, Choi E, Monaco M, Campanac E, Medynets M, Do T, et al. Derivation of neural stem cells from human adult peripheral CD34+ cells for an autologous model of neuroinflammation. PLoS ONE. 2013;8:e81720 pubmed publisher
Guo H, Zhao Z, Yang Q, Wang M, Bell R, Wang S, et al. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013;33:6181-90 pubmed publisher
Silva N, Gimble J, Sousa N, Reis R, Salgado A. Combining adult stem cells and olfactory ensheathing cells: the secretome effect. Stem Cells Dev. 2013;22:1232-40 pubmed publisher
Yamaguchi Y, Shao Z, Sharif S, Du X, Myles T, Merchant M, et al. Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. J Biol Chem. 2013;288:3097-111 pubmed publisher
He L, Chen H, Qian L, Chen G, Buzby J. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain Res. 2010;1339:60-9 pubmed publisher
Margaryan G, Mladinic M, Mattioli C, Nistri A. Extracellular magnesium enhances the damage to locomotor networks produced by metabolic perturbation mimicking spinal injury in the neonatal rat spinal cord in vitro. Neuroscience. 2009;163:669-82 pubmed publisher
Nicoleau C, Benzakour O, Agasse F, Thiriet N, Petit J, Prestoz L, et al. Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. Stem Cells. 2009;27:408-19 pubmed publisher
Yu S, Baek S, Brennan R, Bradley C, Park S, Lee Y, et al. Autophagic death of adult hippocampal neural stem cells following insulin withdrawal. Stem Cells. 2008;26:2602-10 pubmed publisher
Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, et al. Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci. 2008;38:245-58 pubmed publisher
Galabova Kovacs G, Catalanotti F, Matzen D, Reyes G, Zezula J, Herbst R, et al. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol. 2008;180:947-55 pubmed publisher
Ruau D, Ensenat Waser R, Dinger T, Vallabhapurapu D, Rolletschek A, Hacker C, et al. Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells. Stem Cells. 2008;26:920-6 pubmed publisher
Hong S, Kang U, Isacson O, Kim K. Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons. J Neurochem. 2008;104:316-24 pubmed
Hong S, Hwang D, Yoon S, Isacson O, Ramezani A, Hawley R, et al. Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells. Mol Ther. 2007;15:1630-9 pubmed
Chang M, Sun W, Ochiai W, Nakashima K, Kim S, Park C, et al. Bcl-XL/Bax proteins direct the fate of embryonic cortical precursor cells. Mol Cell Biol. 2007;27:4293-305 pubmed
Gossrau G, Thiele J, Konang R, Schmandt T, Brüstle O. Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells. Stem Cells. 2007;25:939-49 pubmed
Kang S, Cho M, Seo H, Yoon C, Oh S, Choi Y, et al. Efficient induction of oligodendrocytes from human embryonic stem cells. Stem Cells. 2007;25:419-24 pubmed
Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, et al. Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages. Br J Haematol. 2006;135:703-14 pubmed
Benzing C, Segschneider M, Leinhaas A, Itskovitz Eldor J, Brüstle O. Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2. Neuroreport. 2006;17:1675-81 pubmed
Zhang P, Izrael M, Ainbinder E, Ben Simchon L, Chebath J, Revel M. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol Cell Neurosci. 2006;31:387-98 pubmed
Ni H, Hu S, Sheng W, Olson J, Cheeran M, Chan A, et al. High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells. Brain Res Dev Brain Res. 2004;152:159-69 pubmed
Tsai H, Tessier Lavigne M, Miller R. Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. Development. 2003;130:2095-105 pubmed
image
image 1 :
R&D Systems MAB1326 image 1
Detection of Oligodendrocyte Marker O4 antibody in Differentiated Rat Cortical Stem Cells antibody by Flow Cytometry.
product information
brand :
R&D Systems
master code :
MAB1326
SKU :
MAB1326
product name :
Oligodendrocyte Marker O4 Antibody
unit size :
50 ug
description :
The Human/Mouse/Rat/Chicken Oligodendrocyte Marker O1 Antibody from R&D Systems is a mouse monoclonal antibody to Oligodendrocyte Marker O1. This antibody reacts with human, mouse, rat, chicken. The Human/Mouse/Rat/Chicken Oligodendrocyte Marker O1 Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, CyTOF-ready.
target :
Oligodendrocyte Marker O4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
O4
concentration :
LYOPH
conjugate :
Unconjugated
all available conjugate :
Unconjugated
host :
Mouse
immunogen :
Bovine brain corpus callosum white matter
isotype :
IgM
purity :
IgM-specific Affinity-purified from hybridoma culture supernatant
species :
Human, Mouse, Rat, Chicken
specificity :
Detects human, mouse, rat, and chicken Oligodendrocyte Marker O4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
applications :
Flow Cytometry, Immunocytochemistry, CyTOF-ready
USD :
289
Jul-22 :
313 USD
sizes available :
50 ug (also 25 ug)
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.