Human MICA/B Antibody | R&D Systems MAB13001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human MICA/B Antibody

catalog :

MAB13001

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

159207

reactivity :

human

application :

immunohistochemistry, flow cytometry

citations: 10

Reference
Huang C, Wang S, Chang W, Yeh M, Huang C, Lin Z, et al. Lower protein expression levels of MHC class I chain-related gene A in hepatocellular carcinoma are at high risk of recurrence after surgical resection. Sci Rep. 2018;8:15821 pubmed publisher
Sharma N, Trinidad C, Trembath A, Markiewicz M. NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-α Release. J Immunol. 2017;199:2865-2872 pubmed publisher
Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute J, Flak M, et al. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017;214:2985-2997 pubmed publisher
Cox S, Laza Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, et al. Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol. 2015;45:2324-34 pubmed publisher
Kim H, Bose S, Meyer K, Ray R. Hepatitis C virus impairs natural killer cell-mediated augmentation of complement synthesis. J Virol. 2014;88:2564-71 pubmed publisher
Dupuy S, Lambert M, Zucman D, Choukem S, Tognarelli S, Pagès C, et al. Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog. 2012;8:e1002486 pubmed publisher
Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva Nilsson L. Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells. PLoS ONE. 2011;6:e16899 pubmed publisher
Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, et al. Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma. Oncogene. 2011;30:2622-32 pubmed publisher
Roda Navarro P, Vales Gomez M, Chisholm S, Reyburn H. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc Natl Acad Sci U S A. 2006;103:11258-63 pubmed
Skov S, Pedersen M, Andresen L, Straten P, Woetmann A, Odum N. Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. Cancer Res. 2005;65:11136-45 pubmed

product information

brand :

R&D Systems

master code :

MAB13001

SKU :

MAB13001-100

product name :

Human MICA/B Antibody

description :

The Human MICA/B Antibody from R&D Systems is a mouse monoclonal antibody to MICA/B. This antibody reacts with human. The Human MICA/B Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Blockade of Receptor-ligand Interaction, CyTOF-ready.

target :

MICA/B

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

159207

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

BaF3 mouse pro-B cell line transfected with human MICA, Accession # Q29983

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human MICA/B in direct ELISAs.

gene symbol :

MICA

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB13001

accessionNumbers :

Q29983

applications :

Flow Cytometry, Immunohistochemistry, Blockade of Receptor-ligand Interaction, CyTOF-ready

2020 USD :

339

2021 USD :

359 USD

alt names :

MHC class I chain-related protein A, MHC class I chain-related protein B, MIC, MICA, MICB, PERB11, PERB11.1, PERB11.2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.