Human TREM-1 Antibody | R&D Systems MAB1278-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TREM-1 Antibody

catalog :

MAB1278-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

193015

reactivity :

human, mouse

application :

western blot, neutralization, flow cytometry, activation, dot blot

more info or order :

R&D Systems product webpage

citations: 19

Reference
Brustolin B, Touly N, Maillefer M, Parisot L, Di Pillo E, Derive M, et al. Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity. Front Endocrinol (Lausanne). 2022;13:983827 pubmed publisher
Boudesco C, Nonneman A, Cinti A, Picardi P, Redaelli L, Swijsen S, et al. Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells. Glia. 2022;70:2290-2308 pubmed publisher
Boufenzer A, Carrasco K, Jolly L, Brustolin B, Di Pillo E, Derive M, et al. Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis. Cell Mol Immunol. 2021;18:452-460 pubmed publisher
Campbell G, To R, Spector S. TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function. MBio. 2019;10: pubmed publisher
Hyun J, McMahon R, Lang A, Edwards J, Badilla A, Greene M, et al. HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells. PLoS Pathog. 2019;15:e1007883 pubmed publisher
Canavan M, Walsh A, Bhargava V, Wade S, McGarry T, Marzaioli V, et al. Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis. JCI Insight. 2018;3: pubmed publisher
Jolly L, Carrasco K, Derive M, Lemarié J, Boufenzer A, Gibot S. Targeted endothelial gene deletion of triggering receptor expressed on myeloid cells-1 protects mice during septic shock. Cardiovasc Res. 2018;114:907-918 pubmed publisher
Raggi F, Pelassa S, Pierobon D, Penco F, Gattorno M, Novelli F, et al. Regulation of Human Macrophage M1-M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1. Front Immunol. 2017;8:1097 pubmed publisher
Aldasoro Arguinano A, Dadé S, Stathopoulou M, Derive M, Coumba Ndiaye N, Xie T, et al. TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin. PLoS ONE. 2017;12:e0182226 pubmed publisher
Tammaro A, Derive M, Gibot S, Leemans J, Florquin S, Dessing M. TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives. Pharmacol Ther. 2017;177:81-95 pubmed publisher
Zysset D, Weber B, Rihs S, Brasseit J, Freigang S, Riether C, et al. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. Nat Commun. 2016;7:13151 pubmed publisher
Zhang G, Liu H, Huang J, Chen S, Pan X, Huang H, et al. TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer. Oncotarget. 2016;7:40508-40517 pubmed publisher
Read C, Kuijper J, Hjorth S, Heipel M, Tang X, Fleetwood A, et al. Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1. J Immunol. 2015;194:1417-21 pubmed publisher
Bosco M, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood. 2011;117:2625-39 pubmed publisher
Ingersoll M, Spanbroek R, Lottaz C, Gautier E, Frankenberger M, Hoffmann R, et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood. 2010;115:e10-9 pubmed publisher
Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H. Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis. Arthritis Rheum. 2009;60:1615-23 pubmed publisher
Ho C, Liao W, Wang C, Lu Y, Huang H, Chen H, et al. TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer. Am J Respir Crit Care Med. 2008;177:763-70 pubmed
Horonenko G, Hoyt J, Robbins R, Singarajah C, Umar A, Pattengill J, et al. Soluble triggering receptor expressed on myeloid cell-1 is increased in patients with ventilator-associated pneumonia: a preliminary report. Chest. 2007;132:58-63 pubmed
Fortin C, Lesur O, Fulop T. Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int Immunol. 2007;19:41-50 pubmed

product information

master code :

MAB1278

SKU :

MAB1278-100

product name :

Human TREM-1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human TREM-1 Antibody from R&D Systems is a mouse monoclonal antibody to TREM1. This antibody reacts with human,mouse. The Human TREM-1 Antibody has been validated for the following applications: ELISA Capture,Flow Cytometry,Activation,Bioassay,ELISA Development,ELISA Development (Capture),Western Blot,Dot Blot,Neutralization,Functional Assay,Agonist Activity,CyTOF-ready.

target :

TREM-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

193015

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TREM-1, Ala21-Asn205, Accession # Q9NP99

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human TREM-1 in direct ELISAs.

gene symbol :

TREM1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of TREM-1 antibody in Human Blood Granulocytes antibody by Flow Cytometry.

accessionNumbers :

Q9NP99

applications :

Activation,Bioassay,ELISA Development,ELISA Development (Capture),Flow Cytometry,Western Blot,Dot Blot,Neutralization,Functional Assay,Agonist Activity,CyTOF-ready

extended description :

Clone 193015 was used by HLDA to establish CD designation

USD :

489 USD

product details :

Clone 193015 was used by HLDA to establish CD designation

alt names :

CD354, CD354 antigen, TREM1, TREM-1Triggering receptor expressed on monocytes 1, triggering receptor expressed on myeloid cells 1, triggering-receptor TREM1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage