Glut4 Antibody | R&D Systems MAB1262 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Glut4 Antibody

catalog :

MAB1262

quantity :

200 ug (also 25 ug)

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1F8

reactivity :

rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 13

Reference
Funk N, Munz M, Ott T, Brockmann K, Wenninger Weinzierl A, Kühn R, et al. The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4. Sci Rep. 2019;9:4515 pubmed publisher
Hale L, Howden S, Phipson B, Lonsdale A, Er P, Ghobrial I, et al. 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening. Nat Commun. 2018;9:5167 pubmed publisher
Tashiro A, Shibata S, Takai Y, Uchiwa T, Furuse M, Yasuo S. Changes in photoperiod alter Glut4 expression in skeletal muscle of C57BL/6J mice. Biochem Biophys Res Commun. 2017;485:82-88 pubmed publisher
Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel Wahab O, et al. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med. 2013;210:339-53 pubmed publisher
Dhurandhar E, Dubuisson O, Mashtalir N, Krishnapuram R, Hegde V, Dhurandhar N. E4orf1: a novel ligand that improves glucose disposal in cell culture. PLoS ONE. 2011;6:e23394 pubmed publisher
Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y. Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med. 2009;37:2791-9 pubmed publisher
Schertzer J, Antonescu C, Bilan P, Jain S, Huang X, Liu Z, et al. A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle. Endocrinology. 2009;150:1935-40 pubmed publisher
Fukuda N, Emoto M, Nakamori Y, Taguchi A, Miyamoto S, Uraki S, et al. DOC2B: a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes. Diabetes. 2009;58:377-84 pubmed publisher
Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi M, et al. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol. 2008;28:2202-8 pubmed publisher
Coward R, Welsh G, Yang J, Tasman C, Lennon R, Koziell A, et al. The human glomerular podocyte is a novel target for insulin action. Diabetes. 2005;54:3095-102 pubmed
Shadoan M, Zhang L, Wagner J. Effects of hormone therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeys. Steroids. 2004;69:313-8 pubmed
Nishino Y, Miura T, Miki T, Sakamoto J, Nakamura Y, Ikeda Y, et al. Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection. Cardiovasc Res. 2004;61:610-9 pubmed
Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, et al. Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes. J Biol Chem. 2003;278:38870-4 pubmed

image

image 1 :

Glut4 antibody in L6 Rat Cell Line by Immunocytochemistry (ICC).

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

MAB1262

SKU :

MAB1262

product name :

Glut4 Antibody

Description :

The Rat Glut4 Antibody from R&D Systems is a mouse monoclonal antibody to Glut4. This antibody reacts with rat. The Rat Glut4 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunoprecipitation, Immunoaffinity Purification, Immunocytochemistry.

target :

Glut4

category :

Primary Antibodies

unit size :

200 ug (also 25 ug)

buffer :

Supplied as a 0.2 um filtered solution in PBS. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

1F8

conjugate :

Unconjugated

host :

Mouse

immunogen :

Partially purified vesicles containing Glut4

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Rat

specificity :

Recognizes an epitope in the cytoplasmic portion of rat Glut4 and has been shown to bind only to the muscle-adipose isoform of the glucose transporter, which is antigenically unique from the other transport proteins (1-3). Recognizes Glut4 in human, monkey, rat, mouse, and rabbit systems. It does not recognize this protein in canine systems. Its ability to bind to glucose transporter from other species has not been tested.

gene symbol :

SLC2A4

applications :

Western Blot, Immunohistochemistry, Immunoprecipitation, Immunoaffinity Purification, Immunocytochemistry

USD :

449 USD

alt names :

GLUT-4, GLUT4Glucose transporter type 4, insulin-responsive, insulin-responsive glucose transporter type 4, SLC2A4, solute carrier family 2 (facilitated glucose transporter), member 4, solute carrier family 2, facilitated glucose transporter member 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C, as supplied. 1 month, 2 to 8 °C under sterile conditions after opening. 6 months, -20 to -70 °C under sterile conditions after opening.

more info or order :

R&D Systems product webpage