PD-L2/B7-DC Antibody | R&D Systems MAB1224-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

PD-L2/B7-DC Antibody

catalog :

MAB1224-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

176611

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

R&D Systems product webpage

citations: 13

Reference
Murayama M, Takada E, Takai K, Arimitsu N, Shimizu J, Suzuki T, et al. Nicotine treatment regulates PD-L1 and PD-L2 expression via inhibition of Akt pathway in HER2-type breast cancer cells. PLoS ONE. 2022;17:e0260838 pubmed publisher
Makowska A, Lelabi N, Nothbaum C, Shen L, Busson P, Tran T, et al. Radiotherapy Combined with PD-1 Inhibition Increases NK Cell Cytotoxicity towards Nasopharyngeal Carcinoma Cells. Cells. 2021;10: pubmed publisher
Ono T, Azuma K, Kawahara A, Kakuma T, Sato F, Kawaguchi T, et al. Changes in immune parameters between pre-treatment and recurrence after (chemo) radiation therapy in patients with head and neck cancer. Sci Rep. 2020;10:11973 pubmed publisher
Ahn H, Kim S, Kwon D, Koh J, Kim Y, Kim K, et al. MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function. Int J Mol Sci. 2019;20: pubmed publisher
Lin J, Long J, Wan X, Chen J, Bai Y, Wang A, et al. Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression. BMC Cancer. 2018;18:766 pubmed publisher
Mostafa M, Abdelkader A, Kuroda N, Perez Montiel D, Banerjee A, Hes O, et al. Variation in nuclear size and PD-L2 positivity correlate with aggressive chromophobe renal cell carcinoma. Ann Diagn Pathol. 2018;34:31-35 pubmed publisher
Lamarca A, Nonaka D, Breitwieser W, Ashton G, Barriuso J, McNamara M, et al. PD-L1 expression and presence of TILs in small intestinal neuroendocrine tumours. Oncotarget. 2018;9:14922-14938 pubmed publisher
Lakins M, Ghorani E, Munir H, Martins C, Shields J. Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells. Nat Commun. 2018;9:948 pubmed publisher
Chang H, Hong J, Lee J, Cho H, Ouh Y, Min K, et al. Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization. J Gynecol Oncol. 2018;29:e27 pubmed publisher
Cao L, Wang X, Li S, Zhi Q, Wang Y, Wang L, et al. PD-L1 is a Prognostic Biomarker in Resected NSCLC Patients with Moderate/high Smoking History and Elevated Serum SCCA Level. J Cancer. 2017;8:3251-3260 pubmed publisher
Koh J, Go H, Keam B, Kim M, Nam S, Kim T, et al. Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status. Mod Pathol. 2015;28:1154-66 pubmed publisher
Rojas D, Krishnan R. IFN-gamma generates maturation-arrested dendritic cells that induce T cell hyporesponsiveness independent of Foxp3+ T-regulatory cell generation. Immunol Lett. 2010;132:31-7 pubmed publisher
Das S, Suarez G, Beswick E, Sierra J, Graham D, Reyes V. Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection. J Immunol. 2006;176:3000-9 pubmed

image

image 1 :

Detection of PD-L2 antibody in HepG2 Human Cell Line antibody by Flow Cytometry.

product information

brand :

R&D Systems

MasterCode :

MAB1224

SKU :

MAB1224-100

product name :

PD-L2/B7-DC Antibody

Description :

The PD-L2/B7-DC Antibody from MAB1224-100 is a mab1224 antibody to . The PD-L2/B7-DC Antibody has been validated for the following applications: Q9BQ51.

target :

PD-L2/B7-DC

category :

Primary Antibodies

unit size :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

176611

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human PD-L2/B7-DC, Leu20-Pro219 (predicted), Accession # Q9BQ51

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human PD-L2/B7-DC in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse PD-L2, recombinant human (rh) B7-1, rhB7-2, rhB7-H1, rhB7-H2, or rhB7-H3 is observed.

gene symbol :

PDCD1LG2

accessionNumbers :

Q9BQ51

applications :

Western Blot, Immunohistochemistry

USD :

469 USD

alt names :

B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, Butyrophilin-like Protein, CD273, CD273 antigen, CD273PD-1 ligand 2, MGC142240, PD-1-ligand 2, PDCD1L2MGC142238, PDCD1LG2, PDL2, PDL2B7DC, PD-L2PDCD1 ligand 2, programmed cell death 1 ligand 2, Programmed death ligand 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage