IL-18 R alpha/IL-1 R5 Antibody | R&D Systems MAB12161-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

IL-18 R alpha/IL-1 R5 Antibody

catalog :

MAB12161-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

459 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

112624

reactivity :

mouse

application :

western blot, neutralization

more info or order :

R&D Systems product webpage

citations: 5

Reference
Kupz A, Pai S, Giacomin P, Whan J, Walker R, Hammoudi P, et al. Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells. Sci Rep. 2020;10:13115 pubmed publisher
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, et al. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015;21:820-6 pubmed publisher
Ghose P, Ali A, Fang R, Forbes D, Ballard B, Ismail N. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J Immunol. 2011;187:1333-46 pubmed publisher
Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H. Protection of CD8+ T cells from activation-induced cell death by IL-18. J Leukoc Biol. 2007;82:142-51 pubmed
Kang M, Homer R, Gallo A, Lee C, Crothers K, Cho S, et al. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol. 2007;178:1948-59 pubmed

image

image 1 :

IFN-? Secretion Induced by IL-18/IL-1F4 and Neutraliza-tion by IL-18 Ra/IL-1 R5 Antibody.

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

MAB12161

SKU :

MAB12161-100

product name :

IL-18 R alpha/IL-1 R5 Antibody

Description :

The Mouse IL-18 R alpha/IL-1 R5 Antibody from R&D Systems is a rat monoclonal antibody to IL-18R alpha/IL-1 R5. This antibody reacts with mouse. The Mouse IL-18 R alpha/IL-1 R5 Antibody has been validated for the following applications: Western Blot, Neutralization.

target :

IL-18 R alpha/IL-1 R5

category :

Primary Antibodies

unit size :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

112624

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse IL-18 R alpha , Ser19-Gly326, Accession # Q61098

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse IL-18 R in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant mouse (rm) IL-1 RI, rmIL-1 RII, rhIL-1 R3, recombinant human (rh) IL-1 R4, rhIL-1 R5, recombinant rat IL-1 R6, rmIL-1 R7, rhIL-1 R8, rhIL-1 R9, or rmSIGIRR.

gene symbol :

Il18rap

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

Q61098

applications :

Western Blot, Neutralization

USD :

459 USD

alt names :

CD218a, CD218a;CDw218a;IL18R1;IL18RA;IL-18Ralpha;IL-18R-alpha;IL18Ralpha2;IL1RRP;IL-1Rrp;Interleukin-18 receptor 1, IL-1 R5, IL-1 Rrp, IL-18 R1, IL18R alpha, IL18R1, IL-18Ra

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage